scholarly journals Chitosan‐Based, Biocompatible, Solution Processable Films for In Vivo Localization of Neural Interface Devices

2019 ◽  
Vol 5 (3) ◽  
pp. 1900663 ◽  
Author(s):  
Onni J. Rauhala ◽  
Soledad Dominguez ◽  
George D. Spyropoulos ◽  
Jose Javier Ferrero ◽  
Talia R. Boyers ◽  
...  
Keyword(s):  
Neural Interface ◽  
Solution Processable ◽  
Interface Devices

scholarly journals Massively parallel microwire arrays integrated with CMOS chips for neural recording

2020 ◽  
Vol 6 (12) ◽  
pp. eaay2789 ◽  
Author(s):  
Abdulmalik Obaid ◽  
Mina-Elraheb Hanna ◽  
Yu-Wei Wu ◽  
Mihaly Kollo ◽  
Romeo Racz ◽  
...  
Keyword(s):  
Large Scale ◽  
Modular Design ◽  
Three Dimensional ◽  
Field Potential ◽  
Neural Interface ◽  
Neural Communication ◽  
New Strategy ◽  
Planar Silicon ◽  
Interface Devices ◽  
Silicon Based

Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.

Insulating Biomaterials Research for Implantable Microelectronic Devices

2003 ◽  
Vol 773 ◽  
Author(s):  
David J. Edell
Keyword(s):  
Chemical Resistance ◽  
Chemical Vapor ◽  
Film Coating ◽  
Neural Interface ◽  
Thin Film Coating ◽  
Accelerated Degradation ◽  
Microelectronic Devices ◽  
Chemical Vapor Deposited

AbstractDevelopments in the field of BioMEMS share many of the same issues encountered in the development of neural interface technology that has been underway for many decades. In addition to issues of function, other issues such as biocompatibility and bioresistance have also presented great challenges. The focus of this paper is on the development and testing of electrically insulating biomaterials for micro-devices that can be implanted in biological systems. A variety of accelerated degradation and accelerated detection of degradation techniques have been developed and are used to screen candidate materials. Direct tests of mechanical properties, adhesion, and chemical resistance are used for further assessment. Promising materials indicate what chemistry might be suitable for development of a Chemical Vapor Deposited (CVD) thin film coating. CVD coatings are under development that may be useful for insulation of very small, micromachined elements of an implantable device while only increasing the size of the device by a few micrometers. Materials passing in-vitro testing are then considered for in-vivo testing. Novel instrumentation for testing devices in-vivo has been developed.

CMOS-based on-chip neural interface devices for optogenetics

2015 ◽  
Author(s):  
Takashi Tokuda ◽  
Hiroaki Takehara ◽  
Toshihiko Noda ◽  
Kiyotaka Sasagawa ◽  
Jun Ohta
Keyword(s):  
Neural Interface ◽  
On Chip ◽  
Interface Devices

scholarly journals Characterization of a-SiCx:H thin films as an encapsulation material for integrated silicon based neural interface devices

2007 ◽  
Vol 516 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Jui-Mei Hsu ◽  
Prashant Tathireddy ◽  
Loren Rieth ◽  
A. Richard Normann ◽  
Florian Solzbacher
Keyword(s):  
Thin Films ◽  
Neural Interface ◽  
Interface Devices ◽  
Silicon Based

scholarly journals A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yoo Na Kang ◽  
Namsun Chou ◽  
Jae-Won Jang ◽  
Han Kyoung Choe ◽  
Sohee Kim
Keyword(s):  
Microelectrode Array ◽  
Neurological Diseases ◽  
Three Dimensional ◽  
Critical Issue ◽  
Neural Interface ◽  
Neural Interfaces ◽  
Dimensional Structure ◽  
Microfluidic Channels ◽  
Before And After

AbstractThe demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural networks. Direct intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain, and it expands the utility of drugs by bypassing the blood–brain barrier (BBB). In addition, uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes, pointing to a critical issue still to be overcome. Although neural interfaces comprised of a collection of microneedles in an array have been used for various applications, it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures, which differ from two-dimensionally fabricated shank-type neural probes. Here we present a method to provide such three-dimensional needle-type arrays with chemical delivery functionality. We fabricated a microfluidic interconnection cable (µFIC) and integrated it with a flexible penetrating microelectrode array (FPMA) that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array base. We successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl injection. This suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities.

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