Illuminating Diverse Concomitant DNA Logic Gates and Concatenated Circuits with Hairpin DNA‐Templated Silver Nanoclusters as Universal Dual‐Output Generators

2020 ◽  
Vol 32 (17) ◽  
pp. 1908480 ◽  
Author(s):  
Mengmeng Lv ◽  
Weijun Zhou ◽  
Daoqing Fan ◽  
Yuchun Guo ◽  
Xiaoqing Zhu ◽  
...  
Keyword(s):  
Logic Gates ◽  
Silver Nanoclusters ◽  
Hairpin Dna

Ratiometric fluorescence analysis for miR-141 detection with hairpin DNA-templated silver nanoclusters

2021 ◽  
Author(s):  
Meiqing Liu ◽  
Ren Shen ◽  
Haoran Li ◽  
Yanwei Jia ◽  
Pui-In Mak ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Fluorescence Analysis ◽  
Silver Nanoclusters ◽  
Ratiometric Fluorescence ◽  
Hairpin Dna ◽  
Robust Detection ◽  
Diagnosis And Prognosis

MicroRNAs (miRNAs) are important biomarkers for diseases diagnosis and prognosis. Accurate and robust detection of miRNAs greatly facilitates the early diagnosis and progress assessment of certain cancers. The current miRNAs...

scholarly journals Noncanonical Head-to-Head Hairpin DNA Dimerization Is Essential for the Synthesis of Orange Emissive Silver Nanoclusters

ACS Nano ◽  
2020 ◽  
Vol 14 (7) ◽  
pp. 8697-8706 ◽  
Author(s):  
Pratik Shah ◽  
Riddhi Nagda ◽  
Il Lae Jung ◽  
Yong Joo Bhang ◽  
Sang-Woo Jeon ◽  
...  
Keyword(s):  
Silver Nanoclusters ◽  
Hairpin Dna

Changes in Spectra and Conformation of Hairpin DNA-Stabilized Silver Nanoclusters Induced by Stem Sequence Perturbations

Langmuir ◽  
2016 ◽  
Vol 32 (2) ◽  
pp. 569-576 ◽  
Author(s):  
Jackson Travis Del Bonis-O’Donnell ◽  
Sumita Pennathur ◽  
Deborah K. Fygenson
Keyword(s):  
Silver Nanoclusters ◽  
Hairpin Dna

Characterizing Fluorescence Emissions of Hairpin DNA-Templated Silver Nanoclusters by cDNA Hybridization

2021 ◽  
Vol 21 (8) ◽  
pp. 4134-4138
Author(s):  
Seyeon Kim ◽  
Geumhee Ha ◽  
Jongback Gang
Keyword(s):  
Small Molecules ◽  
Fluorescence Intensity ◽  
Fluorescence Emission ◽  
Dna Probes ◽  
Silver Nanoclusters ◽  
Wild Type ◽  
Hairpin Dna ◽  
Stem Loop ◽  
Cdna Hybridization ◽  
Target Molecules

Stem-loop hairpin DNA probes have high hybridization specificity and unique selectivity to target molecules such as DNA and small molecules. DNA-templated silver nanoclusters (DNA-AgNCs) has been widely used to detect biomolecules of interest due to the photostable, bright, and efficient methods. In this study, we measured fluorescence emission of hairpin DNA upon hybridization with cDNA and mutant cDNA (cDNA-1) or mutant cDNA containing mismatched bases in the stem region (cDNA-2). Fluorescence intensity of hairpin DNA-AgNCs in the presence of cDNA was 1.80 times higher than that of hairpin DNA-AgNCs alone, but decreased to 66% in the presence of cDNA-1 containing mismatched base corresponding to the hairpin stem region. This study demonstrated that fluorescence intensities of hairpin DNA-AgNCs were dependent on hybridization with either wild-type and mutant cDNAs.

Construction of fluorescence logic gates responding to telomerase and miRNA based on DNA-templated silver nanoclusters and hybridization chain reaction

Nanoscale ◽  
2021 ◽  
Author(s):  
Yiting Jiang ◽  
Zhenzhen Guo ◽  
Mingyuan Wang ◽  
Jinjiang Cui ◽  
Peng Miao
Keyword(s):  
Logic Gates ◽  
Telomerase Activity ◽  
Simultaneous Analysis ◽  
Silver Nanoclusters ◽  
Hybridization Chain Reaction ◽  
Chain Reaction

In this study, we have developed novel fluorescence logic gates for simultaneous analysis of telomerase activity and miRNA. An imperfectly complementary duplex is assembled which can be destroyed by telomerase...

scholarly journals DNA Dumbbell and Chameleon Silver Nanoclusters for miRNA Logic Operations

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Yiting Jiang ◽  
Peng Miao
Keyword(s):  
Early Diagnosis ◽  
Logic Gates ◽  
Silver Nanoclusters ◽  
Dna Nanostructures ◽  
Fundamental Issue ◽  
Ratiometric Fluorescence ◽  
Complex Biological System ◽  
Dna Nanostructure ◽  
Logic Operations ◽  
Selective Analysis

Multiplex miRNA analysis is a fundamental issue for exploring a complex biological system and early diagnosis of miRNA-related diseases. Herein, we have developed a series of novel logic gates for miRNA analysis coupling DNA nanostructures and chameleon silver nanoclusters (AgNCs). DNA dumbbell structures are firstly designed with two independent nucleation sequences for AgNCs at the 5′ and 3′ ends, respectively. By introducing different miRNA inputs, separations of two AgNCs are controlled and the fluorescence property of AgNCs changes. By studying the ratiometric fluorescence responses, sensitive and selective analysis of multiple miRNAs can be achieved. The present work provides powerful tools for miRNA diagnostics and may also guide future DNA nanostructure-based logic gates.

Hairpin DNA probes based on target-induced in situ generation of luminescent silver nanoclusters

2014 ◽  
Vol 50 (37) ◽  
pp. 4849 ◽  
Author(s):  
Yan Xiao ◽  
Zhengjun Wu ◽  
Kwok-Yin Wong ◽  
Zhihong Liu
Keyword(s):  
Dna Probes ◽  
Silver Nanoclusters ◽  
Hairpin Dna ◽  
In Situ Generation
Sign in / Sign up

Export Citation Format

Share Document