Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery

2020 ◽  
Vol 8 (32) ◽  
pp. 7275-7287
Author(s):  
Parinaz Sabourian ◽  
Jeff Ji ◽  
Victor Lotocki ◽  
Alexandre Moquin ◽  
Ramez Hanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyaluronic Acid ◽  
Small Molecules ◽  
Protein Delivery ◽  
Stimuli Responsive ◽  
Glioblastoma Cells ◽  
One Pot ◽  
Self Assembled

Chitosan is functionalized with oxidative stress-sensitive thioketal entities in a one-pot methodology, and self-assembled into drugs or protein loaded dual stimuli responsive nanoparticles, which kill glioblastoma cells and increase nerve outgrowth.

Stimuli-responsive self-assembled dendrimers for oral protein delivery

2019 ◽  
Vol 315 ◽  
pp. 206-213 ◽  
Author(s):  
Zhiying Zeng ◽  
Dongmei Qi ◽  
Lan Yang ◽  
Jin Liu ◽  
Yaqin Tang ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Stimuli Responsive ◽  
Oral Protein Delivery ◽  
Self Assembled

Organic nanoparticles composed of Fréchet-type dendrons: synthesis, characterization, self-assembly and reversible guest encapsulation

2014 ◽  
Vol 2 (34) ◽  
pp. 5576-5584 ◽  
Author(s):  
Sreedevi Krishnakumar ◽  
Karical R. Gopidas
Keyword(s):  
Gold Nanoparticle ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Morphological Transformation ◽  
One Pot ◽  
Organic Nanoparticles ◽  
On Demand ◽  
Gold Core ◽  
Self Assembled

Novel Fréchet-type dendron based organic nanodots exhibiting stimuli responsive reversible morphological transformation have been synthesized by a one-pot reaction which involves etching off gold core of a gold nanoparticle cored dendrimer. Self-assembled FDNs can be utilized for encapsulation and on-demand release of guests.

scholarly journals Stimuli responsive dynamic transformations in supramolecular gels

2021 ◽  
Author(s):  
Santanu Panja ◽  
Dave J. Adams
Keyword(s):  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Stimuli Responsive ◽  
Dynamic Changes ◽  
Supramolecular Gels ◽  
Self Assembled ◽  
Physical And Chemical ◽  
And Chemical Properties

Stimuli responsive dynamic changes in the networks of self-assembled gels result in an alteration of physical and chemical properties of the gel with time.

scholarly journals Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 321
Author(s):  
Shenghui Zhong ◽  
Peng Liu ◽  
Jinsong Ding ◽  
Wenhu Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
High Dose ◽  
One Pot ◽  
Inflammatory Site ◽  
Pei Nanoparticles ◽  
Toxic Reactions

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.

scholarly journals Antioxidant-Loaded Mucoadhesive Nanoparticles for Eye Drug Delivery: A New Strategy to Reduce Oxidative Stress

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 379
Author(s):  
Sandra Cordeiro ◽  
Beatriz Silva ◽  
Ana Margarida Martins ◽  
Helena Margarida Ribeiro ◽  
Lídia Gonçalves ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyaluronic Acid ◽  
Zeta Potential ◽  
Retinal Pigment ◽  
Release Kinetic ◽  
Efficient Treatment ◽  
Non Invasive ◽  
Diffusion Cells ◽  
Franz Diffusion Cells

There are several approaches to treat ocular diseases, which can be invasive or non-invasive. Within the non-invasive, new pharmaceutical strategies based on nanotechnology and mucoadhesive polymers are emerging methodologies, which aim to reach an efficient treatment of eye diseases. The aim of this work was the development of novel chitosan/hyaluronic acid nanoparticle systems with mucoadhesive properties, intended to encapsulate antioxidant molecules (e.g., crocin) aiming to reduce eye oxidative stress and, consequently, ocular disease. An ultraviolet (UV) absorber molecule, actinoquinol, was also added to the nanoparticles, to further decrease oxidative stress. The developed nanoparticles were characterized and the results showed a mean particle size lower than 400 nm, polydispersity index of 0.220 ± 0.034, positive zeta potential, and high yield. The nanoparticles were also characterized in terms of pH, osmolality, and viscosity. Mucoadhesion studies involving the determination of zeta potential, viscosity, and tackiness, showed a strong interaction between the nanoparticles and mucin. In vitro release studies using synthetic membranes in Franz diffusion cells were conducted to unravel the drug release kinetic profile. Ex vitro studies using pig eye scleras in Franz diffusion cells were performed to evaluate the permeation of the nanoparticles. Furthermore, in vitro assays using the ARPE-19 (adult retinal pigment epithelium) cell line showed that the nanoparticles can efficiently decrease oxidative stress and showed low cytotoxicity. Thus, the developed chitosan/hyaluronic acid nanoparticles are a promising system for the delivery of antioxidants to the eye, by increasing their residence time and controlling their delivery.

Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment in Vivo

2016 ◽  
Vol 28 (23) ◽  
pp. 8792-8799 ◽  
Author(s):  
Jing Chen ◽  
Yan Zou ◽  
Chao Deng ◽  
Fenghua Meng ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Treatment ◽  
Protein Delivery

Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Nano Today ◽  
2021 ◽  
Vol 38 ◽  
pp. 101119
Author(s):  
Masoud Delfi ◽  
Rossella Sartorius ◽  
Milad Ashrafizadeh ◽  
Esmaeel Sharifi ◽  
Yapei Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Self Assembled

Self-Assembled Hyaluronic Acid Nanoparticles for Osteoarthritis Treatment

Biomaterials ◽  
2021 ◽  
pp. 120967
Author(s):  
Li-Jung Kang ◽  
Juhwan Yoon ◽  
Jun Gi Rho ◽  
Hwa Seung Han ◽  
Seulbi Lee ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Osteoarthritis Treatment ◽  
Self Assembled
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