Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery

2014 ◽  
Vol 26 (35) ◽  
pp. 6174-6180 ◽  
Author(s):  
Jonas Croissant ◽  
Xavier Cattoën ◽  
Michel Wong Chi Man ◽  
Audrey Gallud ◽  
Laurence Raehm ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica

Mixed Periodic Mesoporous Organosilica Nanoparticles and Core–Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery

2014 ◽  
Vol 26 (24) ◽  
pp. 7214-7220 ◽  
Author(s):  
Jonas Croissant ◽  
Damien Salles ◽  
Marie Maynadier ◽  
Olivier Mongin ◽  
Vincent Hugues ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Periodic Mesoporous Organosilica ◽  
Two Photon ◽  
Mesoporous Organosilica ◽  
Photon Imaging ◽  
Two Photon Imaging

Construction of pH responsive periodic mesoporous organosilica with histidine framework (His-PMO) for drug delivery

2019 ◽  
Vol 277 ◽  
pp. 761-768 ◽  
Author(s):  
Wenpei Zhang ◽  
Haohua Ma ◽  
Jiahui Hua ◽  
Wenqi Zhang ◽  
Cheng Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica

scholarly journals Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 890
Author(s):  
Shanmugavel Chinnathambi ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
The Body ◽  
Functional Surface ◽  
Periodic Mesoporous Organosilica ◽  
Mesoporous Organosilica ◽  
Anti Cancer ◽  
Porous Nanomaterials

Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.

Mesoporous organosilica hybrids with a tunable amphoteric framework for controlled drug delivery

2014 ◽  
Vol 2 (38) ◽  
pp. 6487-6499 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Ji-Hye Park ◽  
Jae-Ho Bae ◽  
Sun-Hee Kim ◽  
Chang-Sik Ha
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Base Hydrolysis ◽  
Mesoporous Organosilica

The integrated nitrile groups in the pore walls of the DU-MSH-CN were converted into reactive –COOH or –NH2groups, by an acid or base hydrolysis technique to achieve large amounts of either –COOH or –NH2groups into the pore walls. Thein vitrodrug release and biocompatibility tests proved the organosilica hybrids suitable for drug carriers in cancer therapy.

Novel Thioacetal-Bridged Hollow Mesoporous Organosilica Nanoparticles with ROS-Responsive Biodegradability for Smart Drug Delivery

NANO ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1950141 ◽  
Author(s):  
Zeyang Lin ◽  
Long Xu ◽  
Jianfeng Zhang ◽  
Zhou Li ◽  
Jinshun Zhao
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Organosilica ◽  
Smart Drug ◽  
Smart Drug Delivery

Intelligent, efficient silica nanoparticles for drug delivery system in cancer therapy have a great application potential, but the biodegradability of silica nanoparticles becomes an intractable hindrance. In this work, novel reactive oxygen species (ROS)-responsive hollow mesoporous organosilica nanoparticles (HMONs) coated with polydopamine (PDA) biofilm and amino-terminated methoxy poly(ethylene glycol) (mPEG-NH[Formula: see text] were synthesized and applied in the smart drug delivery system (HMONs@PDA-mPEG) for the delivery of doxorubicin (DOX). The nanostructures and morphologies of nanoparticles were characterized by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), N2 adsorption/desorption, dynamic light scattering (DLS) and thermogravimetric analysis. Based on the “chemical homology” mechanism, physiologically active thioacetal-bridged silsesquioxane was molecularly incorporated into the framework of silica nanoparticles to form ROS-responsive HMONs, which was verified by the in vitro degradation experiment. The in vitro drug release profiles showed a synergistically pH-dependent and ROS-responsive drug release effect. MTT assay toward A549 cells demonstrated that drug carriers had a biocompatibility, and DOX-loaded nanoparticles (DNs) presented a concentration-dependent and time-dependent cell growth inhibition effect. In summary, the novel ROS-responsive HMONs@PDA-mPEG had a promising application as a smart drug delivery system in biomedical field.

scholarly journals Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin

Inorganics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 16 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Sanja Djordjević ◽  
Vesna Kojić ◽  
Djordje Janaćković
Keyword(s):  
High Efficiency ◽  
High Surface ◽  
High Surface Area ◽  
Treatment Strategies ◽  
Parasitic Infections ◽  
Periodic Mesoporous Organosilica ◽  
Surface Attachment ◽  
Mesoporous Organosilica ◽  
Effective Delivery

Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m2/g). The material’s surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues.

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