Mesoporous organosilica hybrids with a tunable amphoteric framework for controlled drug delivery

2014 ◽  
Vol 2 (38) ◽  
pp. 6487-6499 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Ji-Hye Park ◽  
Jae-Ho Bae ◽  
Sun-Hee Kim ◽  
Chang-Sik Ha
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Base Hydrolysis ◽  
Mesoporous Organosilica

The integrated nitrile groups in the pore walls of the DU-MSH-CN were converted into reactive –COOH or –NH2groups, by an acid or base hydrolysis technique to achieve large amounts of either –COOH or –NH2groups into the pore walls. Thein vitrodrug release and biocompatibility tests proved the organosilica hybrids suitable for drug carriers in cancer therapy.

Evaluation of clay-ionene nanocomposite carriers for controlled drug delivery: Synthesis, in vitro drug release, and kinetics

2019 ◽  
Vol 225 ◽  
pp. 122-132 ◽  
Author(s):  
Hany El-Hamshary ◽  
Mohamed H. El-Newehy ◽  
Meera Moydeen Abdulhameed ◽  
Ayman El-Faham ◽  
Abeer S. Elsherbiny
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
In Vitro Drug Release

scholarly journals Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 2051 ◽  
Author(s):  
Alecsandra Ferreira Tomaz ◽  
Sandra Sobral de Carvalho ◽  
Rossemberg Cardoso Barbosa ◽  
Suédina L. Silva ◽  
Marcos Sabino Gutierrez ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Delivery System ◽  
Drug Carriers ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Studies ◽  
Chitosan Membranes ◽  
Crosslinked Chitosan ◽  
Cross Linker

The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

scholarly journals Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

2012 ◽  
Vol 62 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Martins Emeje ◽  
Lucy John-Africa ◽  
Yetunde Isimi ◽  
Olobayo Kunle ◽  
Sabinus Ofoefule
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Polymer Blends ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Delivery ◽  
Dosage Forms ◽  
Controlled Drug Delivery System

Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline Sustained release (SR) dosage forms enable prolonged and continuous deposition of the drug in the gastrointestinal (GI) tract and improve the bioavailability of medications characterized by a narrow absorption window. In this study, a new strategy is proposed for the development of SR dosage forms for theophylline (TPH). Design of the delivery system was based on a sustained release formulation, with a modified coating technique and swelling features aimed to extend the release time of the drug. Different polymers, such as Carbopol 71G (CP), sodium carboxymethylcellulose (SCMC), ethylcellulose (EC) and their combinations were tried. Prepared matrix tablets were coated with a 5 % (m/m) dispersion of Eudragit (EUD) in order to get the desired sustained release profile over a period of 24 h. Various formulations were evaluated for micromeritic properties, drug concentration and in vitro drug release. It was found that the in vitro drug release rate decreased with increasing the amount of polymer. Coating with EUD resulted in a significant lag phase in the first two hours of dissolution in the acidic pH of simulated gastric fluid (SGF) due to decreased water uptake, and hence decreased driving force for drug release. Release became faster in the alkaline pH of simulated intestinal fluid (SIF) owing to increased solubility of both the coating and matrixing agents. The optimized formulation was subjected to in vivo studies in rabbits and the pharmacokinetic parameters of developed formulations were compared with the commercial (Asmanyl®) formulation. Asmanyl® tablets showed faster absorption (tmax 4.0 h) compared to the TPH formulation showing a tmax value of 8.0 h. The Cmax and AUC values of TPH formulation were significantly (p < 0.05) higher than those for Asmanyl®, revealing relative bioavailability of about 136.93 %. Our study demonstrated the potential usefulness of eudraginated polymers for the oral delivery of the sparingly soluble drug theophylline.

Synthesis of N-Carboxymethyl Chitosan Beads for Controlled Drug Delivery Applications

2006 ◽  
Vol 514-516 ◽  
pp. 1015-1019 ◽  
Author(s):  
Rangasamy Jayakumar ◽  
Rui L. Reis ◽  
João F. Mano
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Controlled Drug Delivery ◽  
Gastric Fluid ◽  
Carboxymethyl Chitosan ◽  
Water Soluble ◽  
Buffer Solution ◽  
Chitosan Beads

N-Carboxymethyl chitosan (NCMC) is a water soluble derivative of chitosan. The NCMC beads were prepared by using ionotropic gelation process with the counter polyanion tripolyphoshate at pH 4.0 and characterized by scanning electron microscopy. The swelling behavior of the beads at different time intervals was monitored at different pH conditions. The in vitro drug release behavior in various pH solutions was studied using indomethacin as a model drug with two different concentrations (0.3 and 0.6% w/w). The release percent of indomethacin from NCMC beads was found to increase with increasing of pH in phosphate buffer solution medium due to the ionization of carboxymethyl group and high solubility of indomethacin in alkaline medium. These results indicated that the NCMC beads are useful for controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.

scholarly journals Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro.

1995 ◽  
Vol 18 (8) ◽  
pp. 1154-1158 ◽  
Author(s):  
Motoko KANKE ◽  
Emi TANABE ◽  
Hirokazu KATAYAMA ◽  
Yoko KODA ◽  
Hironori YOSHITOMI
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Controlled Drug Delivery

scholarly journals Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kyle Battiston ◽  
Ian Parrag ◽  
Matthew Statham ◽  
Dimitra Louka ◽  
Hans Fischer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Inflammatory Responses ◽  
Release Kinetics ◽  
Drug Loading ◽  
Rabbit Model ◽  
Drug Carriers ◽  
Surface Erosion ◽  
Sustained Drug Delivery

AbstractPolymeric drug carriers are widely used for providing temporal and/or spatial control of drug delivery, with corticosteroids being one class of drugs that have benefitted from their use for the treatment of inflammatory-mediated conditions. However, these polymer-based systems often have limited drug-loading capacity, suboptimal release kinetics, and/or promote adverse inflammatory responses. This manuscript investigates and describes a strategy for achieving controlled delivery of corticosteroids, based on a discovery that low molecular weight corticosteroid dimers can be processed into drug delivery implant materials using a broad range of established fabrication methods, without the use of polymers or excipients. These implants undergo surface erosion, achieving tightly controlled and reproducible drug release kinetics in vitro. As an example, when used as ocular implants in rats, a dexamethasone dimer implant is shown to effectively inhibit inflammation induced by lipopolysaccharide. In a rabbit model, dexamethasone dimer intravitreal implants demonstrate predictable pharmacokinetics and significantly extend drug release duration and efficacy (>6 months) compared to a leading commercial polymeric dexamethasone-releasing implant.

Novel Thioacetal-Bridged Hollow Mesoporous Organosilica Nanoparticles with ROS-Responsive Biodegradability for Smart Drug Delivery

NANO ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1950141 ◽  
Author(s):  
Zeyang Lin ◽  
Long Xu ◽  
Jianfeng Zhang ◽  
Zhou Li ◽  
Jinshun Zhao
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Organosilica ◽  
Smart Drug ◽  
Smart Drug Delivery

Intelligent, efficient silica nanoparticles for drug delivery system in cancer therapy have a great application potential, but the biodegradability of silica nanoparticles becomes an intractable hindrance. In this work, novel reactive oxygen species (ROS)-responsive hollow mesoporous organosilica nanoparticles (HMONs) coated with polydopamine (PDA) biofilm and amino-terminated methoxy poly(ethylene glycol) (mPEG-NH[Formula: see text] were synthesized and applied in the smart drug delivery system (HMONs@PDA-mPEG) for the delivery of doxorubicin (DOX). The nanostructures and morphologies of nanoparticles were characterized by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), N2 adsorption/desorption, dynamic light scattering (DLS) and thermogravimetric analysis. Based on the “chemical homology” mechanism, physiologically active thioacetal-bridged silsesquioxane was molecularly incorporated into the framework of silica nanoparticles to form ROS-responsive HMONs, which was verified by the in vitro degradation experiment. The in vitro drug release profiles showed a synergistically pH-dependent and ROS-responsive drug release effect. MTT assay toward A549 cells demonstrated that drug carriers had a biocompatibility, and DOX-loaded nanoparticles (DNs) presented a concentration-dependent and time-dependent cell growth inhibition effect. In summary, the novel ROS-responsive HMONs@PDA-mPEG had a promising application as a smart drug delivery system in biomedical field.

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