Carbon Nanodots Featuring Efficient FRET for Real-Time Monitoring of Drug Delivery and Two-Photon Imaging

2013 ◽  
Vol 25 (45) ◽  
pp. 6569-6574 ◽  
Author(s):  
Jing Tang ◽  
Biao Kong ◽  
Hao Wu ◽  
Ming Xu ◽  
Yongcheng Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Carbon Nanodots ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

2012 ◽  
Vol 161 (2) ◽  
pp. 656-667 ◽  
Author(s):  
Sari Pappinen ◽  
Evgeny Pryazhnikov ◽  
Leonard Khiroug ◽  
Marica B. Ericson ◽  
Marjo Yliperttula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Cultures ◽  
Skin Toxicity ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Percutaneous Drug Delivery ◽  
In Vivo Assessment

Mixed Periodic Mesoporous Organosilica Nanoparticles and Core–Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery

2014 ◽  
Vol 26 (24) ◽  
pp. 7214-7220 ◽  
Author(s):  
Jonas Croissant ◽  
Damien Salles ◽  
Marie Maynadier ◽  
Olivier Mongin ◽  
Vincent Hugues ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Periodic Mesoporous Organosilica ◽  
Two Photon ◽  
Mesoporous Organosilica ◽  
Photon Imaging ◽  
Two Photon Imaging

A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

2020 ◽  
Vol 56 (69) ◽  
pp. 9986-9989
Author(s):  
Amit Kumar Singh ◽  
Moumita Kundu ◽  
Samrat Roy ◽  
Biswajit Roy ◽  
Sk. Sheriff Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photon Absorption ◽  
Cancer Drug ◽  
Real Time Monitoring ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Anti Cancer

A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release.

Development of a Novel Approach for Real‐Time Two‐Photon Imaging of the Rat Hypothalamus In Vivo

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Colin H. Brown ◽  
Ranjan K. Roy ◽  
Jordan P. Hamm ◽  
Javier E. Stern
Keyword(s):  
Real Time ◽  
Rat Hypothalamus ◽  
Two Photon ◽  
Novel Approach ◽  
Photon Imaging ◽  
Two Photon Imaging

scholarly journals Real-time 3D movement correction for two-photon imaging in behaving animals

2020 ◽  
Vol 17 (7) ◽  
pp. 741-748 ◽  
Author(s):  
Victoria A. Griffiths ◽  
Antoine M. Valera ◽  
Joanna YN. Lau ◽  
Hana Roš ◽  
Thomas J. Younts ◽  
...  
Keyword(s):  
Real Time ◽  
Two Photon ◽  
Movement Correction ◽  
Photon Imaging ◽  
Two Photon Imaging

Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18966-18976 ◽  
Author(s):  
Dong-Yang Zhang ◽  
Yue Zheng ◽  
Hang Zhang ◽  
Liang He ◽  
Cai-Ping Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Ruthenium Complex ◽  
Carbon Nanodots ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging

Nanohybrids can in most cases kill cancer cells more efficiently as compared with free photosensitizers.

Three-in-One Self-Assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy

2018 ◽  
Vol 10 (34) ◽  
pp. 28301-28313 ◽  
Author(s):  
Gang-Gang Yang ◽  
Liang Hao ◽  
Qian Cao ◽  
Hang Zhang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Two Photon ◽  
Photon Imaging ◽  
Self Assembled ◽  
Two Photon Imaging ◽  
Dual Drug
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