An NRP1/MDM2‐Targeted D‐Peptide Supramolecular Nanomedicine for High‐Efficacy and Low‐Toxic Liver Cancer Therapy

2021 ◽  
pp. 2002197
Author(s):  
Yunjiang Zhou ◽  
Yaxin Chen ◽  
Yingying Tan ◽  
Rong Hu ◽  
Miao‐Miao Niu
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxic

Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy

2018 ◽  
Vol 30 (30) ◽  
pp. 1704490 ◽  
Author(s):  
Xiaobo Jia ◽  
Yihua Zhang ◽  
Yu Zou ◽  
Yao Wang ◽  
Dechao Niu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
High Efficacy ◽  
Redox Enzyme ◽  
Low Toxic

In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy

ACS Nano ◽  
2010 ◽  
Vol 4 (11) ◽  
pp. 6874-6882 ◽  
Author(s):  
Linlin Li ◽  
Fangqiong Tang ◽  
Huiyu Liu ◽  
Tianlong Liu ◽  
Nanjing Hao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxicity ◽  
Silica Nanorattle ◽  
In Vivo Delivery

scholarly journals Cancer Therapy: Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy (Adv. Mater. 30/2018)

2018 ◽  
Vol 30 (30) ◽  
pp. 1870217 ◽  
Author(s):  
Xiaobo Jia ◽  
Yihua Zhang ◽  
Yu Zou ◽  
Yao Wang ◽  
Dechao Niu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
High Efficacy ◽  
Redox Enzyme ◽  
Low Toxic

scholarly journals In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy

ACS Nano ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. 679-679 ◽  
Author(s):  
Linlin Li ◽  
Fangqiong Tang ◽  
Huiyu Liu ◽  
Tianlong Liu ◽  
Nanjing Hao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxicity ◽  
Silica Nanorattle ◽  
In Vivo Delivery

A Redox‐Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self‐Assembly for High‐Efficacy and Low‐Toxic Cancer Therapy

2019 ◽  
Vol 30 (4) ◽  
pp. 1904969 ◽  
Author(s):  
Da‐Song Yang ◽  
Yin‐He Yang ◽  
Yunjiang Zhou ◽  
Li‐Li Yu ◽  
Rui‐Han Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
High Efficacy ◽  
Low Toxic

Exploring Nanoemulsion for Liver Cancer Therapy

2020 ◽  
Vol 16 (4) ◽  
pp. 260-268
Author(s):  
Tanmay Upadhyay ◽  
Vaseem A. Ansari ◽  
Usama Ahmad ◽  
Nazneen Sultana ◽  
Juber Akhtar
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Treatment Plan ◽  
Chemotherapeutic Drugs ◽  
Drug Delivery Vehicles ◽  
Chronic Hepatitis B Virus ◽  
Anti Cancer ◽  
B Virus ◽  
Delivery Vehicles ◽  
Liquid Dosage Form

Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. Among these, at least 0.78 million people died of liver cancer alone. The recognized risk factors for liver cancer include chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, exposure to dietary aflatoxin, fatty liver disease, alcohol-induced cirrhosis, obesity, smoking, diabetes, and iron overload. The treatment plan for early diagnosed patients includes radiation therapy, tumour ablation, surgery, immunotherapy, and chemotherapy. Some sort of drug delivery vehicles has to be used when the treatment plan is targeted chemotherapy. Nanoemulsions are a class of biphasic liquid dosage form which are mixtures of oil and water stabilized by a surfactant. They are either transparent or bluish in hue and serve as a wonderful carrier system for chemotherapeutic drugs. These vehicles have a particle size in the range of 20-200 nm allowing them to be delivered successfully in the deepest of tissues. Recent publications on nanoemulsions reveal their acceptance and a popular choice for delivering both synthetic and herbal drugs to the liver. This work focuses on some anti-cancer agents that utilized the advantages of nanoemulsion for liver cancer therapy.

scholarly journals Biodistribution study of lutetium hydroxyapatite (177Lu-HA) for liver cancer therapy

2021 ◽  
Author(s):  
A. Jadidan ◽  
M. Z. Anwari ◽  
A. Riana ◽  
Y. W. Sari ◽  
D. Hardiansyah
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Biodistribution Study

Gram-scale production of carrier-free fluorescent berberine microrods for selective liver cancer therapy

BioFactors ◽  
2018 ◽  
Vol 44 (5) ◽  
pp. 496-502 ◽  
Author(s):  
Xiao Zheng ◽  
Fan Zhang ◽  
Dan Shao ◽  
Zhanqiang Zhang ◽  
Lianzhi Cui ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Scale Production ◽  
Carrier Free

scholarly journals Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Huiling Lv ◽  
Chao Wu ◽  
Xuan Liu ◽  
Andi Bai ◽  
Yue Cao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Hollow Structure ◽  
Amorphous State ◽  
Outer Diameter ◽  
Drug Delivery Carrier

In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.

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