scholarly journals Biodegradable β ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

2020 ◽  
Vol 9 (11) ◽  
pp. 2000527
Author(s):  
Xingwu Zhou ◽  
Zhimin Luo ◽  
Avijit Baidya ◽  
Han‐jun Kim ◽  
Canran Wang ◽  
...  
Keyword(s):  
Water Insoluble Drug

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

Linear extended release of a water-insoluble drug, carbamazepine, from erodible matrices

1993 ◽  
Vol 94 (1-3) ◽  
pp. 15-22 ◽  
Author(s):  
P. Giunchedi ◽  
L. Maggi ◽  
U. Conte ◽  
A. La Manna
Keyword(s):  
Extended Release ◽  
Water Insoluble Drug

Polymeric Micelles with Water-Insoluble Drug as Hydrophobic Moiety for Drug Delivery

2011 ◽  
Vol 12 (6) ◽  
pp. 2016-2026 ◽  
Author(s):  
Guolin Li ◽  
Jinyao Liu ◽  
Yan Pang ◽  
Ruibin Wang ◽  
Limin Mao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Hydrophobic Moiety ◽  
Water Insoluble Drug

scholarly journals Formulation and Pharmacokinetic Evaluation of Phosal Based Zaltoprofen Solid Self-Nanoemulsifying Drug Delivery System

2019 ◽  
Vol 7 (4) ◽  
pp. 328-338
Author(s):  
Rajan Kalamkar ◽  
Shailesh Wadher
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ternary Phase Diagram ◽  
In Vitro Dissolution ◽  
Size Analysis ◽  
Dissolution Profile ◽  
Globule Size ◽  
Water Insoluble Drug

Background: Phosal based excipients are liquid concentrates containing phospholipids. They are used to solubilize water-insoluble drug and also act as an emulsifier to get the smallest droplet size of the formed emulsion after administration. Objective: The aim is to prepare phosal based self nanoemulsifying drug delivery system (SNEDDS) for water insoluble drug zaltoprofen. Methods: The various parameters like solubility of drug in different vehicles, ternary phase diagram are considered to formulate the stable emulsion which is further characterized by Self emulsification time and globule size analysis to optimize liquid SNEDDS of Zaltoprofen. Optimized L-SNEDDS was converted into free-flowing powder Solid-SNEDDS (S-SNEDDS). S-SNEDDS was evaluated for Globule size analysis after reconstitution, in vitro dissolution study and in vivo pharmacokinetic study in rats. Results: Phosal 53 MCT with highest drug solubility was used as oil along with Tween 80 and PEG 400 as surfactant and cosurfactant respectively to prepare liquid SNEDDS. Neusilin us2 was used as an adsorbent to get free-flowing S-SNEDDS. S-SNEDDS showed improved dissolution profile of the drug as compared to pure drug. In vivo study demonstrated that there is a significant increase in Cmax and AUC of S-SNEDDS compared to zaltoprofen powder. Conclusion: Phosal based SNEDDS formation can be successfully used to improve the dissolution and oral bioavailability of poorly soluble drug zaltoprofen.

An asymmetric coating composed of gelatin and hydroxyapatite for the delivery of water insoluble drug

2008 ◽  
Vol 20 (4) ◽  
pp. 889-896 ◽  
Author(s):  
Junwu Xiao ◽  
Yingchun Zhu ◽  
Yanyan Liu ◽  
Yi Zeng ◽  
Fangfang Xu
Keyword(s):  
Water Insoluble Drug

Effect of Surfactants on Characteristic and In Vitro Release of Meloxicam Loaded in Deformable Liposomes

2012 ◽  
Vol 506 ◽  
pp. 457-460
Author(s):  
Sureewan Duangjit ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Sodium Cholate ◽  
Drug Delivery Carrier ◽  
Release Study ◽  
Water Insoluble Drug ◽  
Vitro Release ◽  
Potential Use

The aim of this study was to investigate the effect of surfactants on characteristic and in vitro release of liposomes containing meloxicam (MX), model of water insoluble drug. The potential use of deformable liposomes for drug delivery system was developed and investigated. The formulation composed of constant amount of phosphatidylcholine (PC) and MX and various amounts of cholesterol (Chol), sodium cholate (NaChol), sodium oleate (NaO) and stearylamine (SA) was formulated by reverse phase evaporation method. The vesicle size, zeta potential, morphology, entrapment efficiency, loading efficiency, stability andin vitrorelease study were evaluated. The result indicated that the entrapment efficiency andin vitrorelease study of vesicle formulations containing surfactants were significantly higher than the conventional liposome and MX suspension. The formulation of 10:2:2:5 PC/MX/Chol/NaO provided the maximum entrapment efficiency and drug release. Our research suggested that MX loaded in deformable liposomes containing surfactants can be potentially used as a drug delivery carrier for water insoluble drug.

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