scholarly journals Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds

2018 ◽  
Vol 7 (11) ◽  
pp. 1701347 ◽  
Author(s):  
Negar Faramarzi ◽  
Iman K. Yazdi ◽  
Mahboubeh Nabavinia ◽  
Andrea Gemma ◽  
Adele Fanelli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Patient Specific ◽  
3D Bioprinting ◽  
Tissue Engineering Scaffolds

scholarly journals 3D Bioprinting: Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds (Adv. Healthcare Mater. 11/2018)

2018 ◽  
Vol 7 (11) ◽  
pp. 1870043 ◽  
Author(s):  
Negar Faramarzi ◽  
Iman K. Yazdi ◽  
Mahboubeh Nabavinia ◽  
Andrea Gemma ◽  
Adele Fanelli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Patient Specific ◽  
3D Bioprinting ◽  
Tissue Engineering Scaffolds

The Fabrication of Tissue Engineering Scaffolds by Inkjet Printing Technology

2018 ◽  
Vol 934 ◽  
pp. 129-133 ◽  
Author(s):  
Chao Fan Lv ◽  
Li Ya Zhu ◽  
Jian Ping Shi ◽  
Zong An Li ◽  
Wen Lai Tang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sodium Alginate ◽  
Inkjet Printing ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Tissue Engineering Scaffolds ◽  
Printing Technology ◽  
3D Printed ◽  
Inkjet Printing Technology ◽  
Alginate Scaffold

Three-dimensional (3D) printing has been playing an important role in diverse areas in medicine. In order to promote the development of tissue engineering, this study attempts to fabricate tissue engineering scaffolds using the inkjet printing technology. Sodium alginate, exhibiting similar properties to the native human extracellular matrix (ECM), was used as bioink. The jetted fluid of sodium alginate would be gelatinized when printed into the calcium chloride solution. The characteristics of the 3D-printed sodium alginate scaffold were systematically measured and analyzed. The results show that, the pore size, porosity and degradation property of these scaffolds could be well controlled. This study indicates the capability of 3D bioprinting technology for preparing tissue engineering scaffolds.

Vascular tissue engineering by computer-aided laser micromachining

2010 ◽  
Vol 368 (1917) ◽  
pp. 1891-1912 ◽  
Author(s):  
Anand Doraiswamy ◽  
Roger J. Narayan
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Vascular Tissue ◽  
Laser Micromachining ◽  
Patient Specific ◽  
Tissue Engineering Scaffolds ◽  
Aortic Endothelial Cells ◽  
Computer Aided ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

Many conventional technologies for fabricating tissue engineering scaffolds are not suitable for fabricating scaffolds with patient-specific attributes. For example, many conventional technologies for fabricating tissue engineering scaffolds do not provide control over overall scaffold geometry or over cell position within the scaffold. In this study, the use of computer-aided laser micromachining to create scaffolds for vascular tissue networks was investigated. Computer-aided laser micromachining was used to construct patterned surfaces in agarose or in silicon, which were used for differential adherence and growth of cells into vascular tissue networks. Concentric three-ring structures were fabricated on agarose hydrogel substrates, in which the inner ring contained human aortic endothelial cells, the middle ring contained HA587 human elastin and the outer ring contained human aortic vascular smooth muscle cells. Basement membrane matrix containing vascular endothelial growth factor and heparin was to promote proliferation of human aortic endothelial cells within the vascular tissue networks. Computer-aided laser micromachining provides a unique approach to fabricate small-diameter blood vessels for bypass surgery as well as other artificial tissues with complex geometries.

scholarly journals An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2199 ◽  
Author(s):  
Željka Kačarević ◽  
Patrick Rider ◽  
Said Alkildani ◽  
Sujith Retnasingh ◽  
Ralf Smeets ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Three Dimensional ◽  
Cell Types ◽  
Patient Specific ◽  
Tissue Engineering Scaffolds ◽  
Advantages And Disadvantages ◽  
Spatial Geometry ◽  
Extrusion Printing ◽  
Different Cell Types ◽  
Cancer Studies

Bioprinting is an emerging field in regenerative medicine. Producing cell-laden, three-dimensional structures to mimic bodily tissues has an important role not only in tissue engineering, but also in drug delivery and cancer studies. Bioprinting can provide patient-specific spatial geometry, controlled microstructures and the positioning of different cell types for the fabrication of tissue engineering scaffolds. In this brief review, the different fabrication techniques: laser-based, extrusion-based and inkjet-based bioprinting, are defined, elaborated and compared. Advantages and challenges of each technique are addressed as well as the current research status of each technique towards various tissue types. Nozzle-based techniques, like inkjet and extrusion printing, and laser-based techniques, like stereolithography and laser-assisted bioprinting, are all capable of producing successful bioprinted scaffolds. These four techniques were found to have diverse effects on cell viability, resolution and print fidelity. Additionally, the choice of materials and their concentrations were also found to impact the printing characteristics. Each technique has demonstrated individual advantages and disadvantages with more recent research conduct involving multiple techniques to combine the advantages of each technique.

scholarly journals In Vivo Tracking of Tissue Engineered Constructs

Micromachines ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 474 ◽  
Author(s):  
Carmen J. Gil ◽  
Martin L. Tomov ◽  
Andrea S. Theus ◽  
Alexander Cetnar ◽  
Morteza Mahmoudi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
New Technologies ◽  
Imaging Techniques ◽  
Patient Specific ◽  
Great Promise ◽  
Tissue Engineering Scaffolds ◽  
Tissue Constructs ◽  
High Penetration ◽  
Penetration Depths

To date, the fields of biomaterials science and tissue engineering have shown great promise in creating bioartificial tissues and organs for use in a variety of regenerative medicine applications. With the emergence of new technologies such as additive biomanufacturing and 3D bioprinting, increasingly complex tissue constructs are being fabricated to fulfill the desired patient-specific requirements. Fundamental to the further advancement of this field is the design and development of imaging modalities that can enable visualization of the bioengineered constructs following implantation, at adequate spatial and temporal resolution and high penetration depths. These in vivo tracking techniques should introduce minimum toxicity, disruption, and destruction to treated tissues, while generating clinically relevant signal-to-noise ratios. This article reviews the imaging techniques that are currently being adopted in both research and clinical studies to track tissue engineering scaffolds in vivo, with special attention to 3D bioprinted tissue constructs.

Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

2019 ◽  
Author(s):  
AS Arampatzis ◽  
K Theodoridis ◽  
E Aggelidou ◽  
KN Kontogiannopoulos ◽  
I Tsivintzelis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressings ◽  
Active Ingredients ◽  
Tissue Engineering Scaffolds

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

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