Dual-Targeting Lactoferrin-Conjugated Polymerized Magnetic Polydiacetylene-Assembled Nanocarriers with Self-Responsive Fluorescence/Magnetic Resonance Imaging for In Vivo Brain Tumor Therapy

2016 ◽  
Vol 5 (6) ◽  
pp. 688-695 ◽  
Author(s):  
Jen-Hung Fang ◽  
Tsung-Lang Chiu ◽  
Wei-Chen Huang ◽  
Yen-Ho Lai ◽  
Shang-Hsiu Hu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Dual Targeting ◽  
Brain Tumor Therapy

In vivo magnetic resonance imaging tracks adult neural progenitor cell targeting of brain tumor

NeuroImage ◽  
2004 ◽  
Vol 23 (1) ◽  
pp. 281-287 ◽  
Author(s):  
Zhenggang Zhang ◽  
Quan Jiang ◽  
Feng Jiang ◽  
Gaungliang Ding ◽  
Ruilan Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Cell Targeting ◽  
Resonance Imaging

Facile preparation of hyaluronic acid and transferrin co-modified Fe3O4nanoparticles with inherent biocompatibility for dual-targeting magnetic resonance imaging of tumors in vivo

2015 ◽  
Vol 44 (46) ◽  
pp. 19836-19843 ◽  
Author(s):  
Jinbin Pan ◽  
Shao-Kai Sun ◽  
Yaqiong Wang ◽  
Yan-Yan Fu ◽  
Xuejun Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hyaluronic Acid ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Resonance Imaging ◽  
Dual Targeting ◽  
Facile Preparation

A biocompatible and sensitive dual-targeting Fe3O4nanoprobe co-modified with biosafe hyaluronic acid and transferrin was developed for tumor-targeted MR imaging.

scholarly journals Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhenqi Jiang ◽  
Bo Yuan ◽  
Nianxiang Qiu ◽  
Yinjie Wang ◽  
Li Sun ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Circulation ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Zeolitic Imidazolate Frameworks ◽  
Resonance Imaging ◽  
Triggered Release ◽  
Receptor Ligand

Abstract Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y1 receptor ligand [Asn28, Pro30, Trp32]-NPY (25–36) for imaging-guided tumor therapy. After Y1 receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy.

Monitoring stem cell migration in the nervous system by in vivo magnetic resonance imaging

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S692-S692
Author(s):  
Mathias Hoehn ◽  
Uwe Himmelreich ◽  
Ralph Weber ◽  
Pedro Ramos-Cabrer ◽  
Susanne Wegener ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nervous System ◽  
Stem Cell ◽  
Cell Migration ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Stem Cell Migration

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

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