Upconversion Nanoparticles Conjugated with Gd3+-DOTA and RGD for Targeted Dual-Modality Imaging of Brain Tumor Xenografts

2013 ◽  
Vol 2 (11) ◽  
pp. 1501-1512 ◽  
Author(s):  
Jiefu Jin ◽  
Zhenhua Xu ◽  
Yue Zhang ◽  
Yan-Juan Gu ◽  
Michael Hon-Wah Lam ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Upconversion Nanoparticles ◽  
Tumor Xenografts ◽  
Dual Modality ◽  
Dual Modality Imaging

Theranostic micelles based on upconversion nanoparticles for dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Nanoscale ◽  
2018 ◽  
Vol 10 (14) ◽  
pp. 6511-6523 ◽  
Author(s):  
Yong Han ◽  
Yanli An ◽  
Gang Jia ◽  
Xihui Wang ◽  
Chen He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Photodynamic Therapy ◽  
Therapeutic Strategies ◽  
Upconversion Nanoparticles ◽  
Curative Surgery ◽  
Dual Modality ◽  
Dual Modality Imaging

Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond to curative surgery, emphasizing the need for the development of more sensitive and effective diagnostic and therapeutic strategies.

Core–shell hybrid upconversion nanoparticles carrying stable nitroxide radicals as potential multifunctional nanoprobes for upconversion luminescence and magnetic resonance dual-modality imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 5249-5261 ◽  
Author(s):  
Chuan Chen ◽  
Ning Kang ◽  
Ting Xu ◽  
Dong Wang ◽  
Lei Ren ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Upconversion Luminescence ◽  
Upconversion Nanoparticles ◽  
Core Shell ◽  
Nitroxide Radicals ◽  
Dual Modality ◽  
Dual Modality Imaging ◽  
Stable Nitroxide

A nitroxide radicals doped SiO2 was coated on upconversion nanoparticles to generate novel UCNP@TEMPO@SiO2 nanoprobes for dual-modality imaging.

scholarly journals Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study

Theranostics ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 2161-2170 ◽  
Author(s):  
Marlène C. Hekman ◽  
Mark Rijpkema ◽  
Constantijn H. Muselaers ◽  
Egbert Oosterwijk ◽  
Christina A. Hulsbergen-Van de Kaa ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Dual Modality ◽  
Dual Modality Imaging ◽  
Intraoperative Visualization

scholarly journals Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging

2015 ◽  
Vol 2 (Suppl 1) ◽  
pp. A89 ◽  
Author(s):  
Charalmpos Tsoukalas ◽  
Gautier Laurent ◽  
Gloria Jiménez Sánchez ◽  
Theodoros Tsotakos ◽  
Rana Bazzi ◽  
...  
Keyword(s):  
Dual Modality ◽  
Dual Modality Imaging ◽  
In Vivo Assessment

scholarly journals Dual-Modality Imaging of Cancer with SPECT/CT

2002 ◽  
Vol 1 (6) ◽  
pp. 449-458 ◽  
Author(s):  
Bruce H. Hasegawa ◽  
Kenneth H. Wong ◽  
Koji Iwata ◽  
William C. Barber ◽  
Andrew B. Hwang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Em Algorithm ◽  
Photon Emission ◽  
Imaging Systems ◽  
Patient Specific ◽  
Emission Computed Tomography ◽  
Functional Information ◽  
Dual Modality ◽  
Photon Attenuation ◽  
Dual Modality Imaging

Dual-modality imaging is an in vivo diagnostic technique that obtains structural and functional information directly from patient studies in a way that cannot be achieved with separate imaging systems alone. Dual-modality imaging systems are configured by combining computed tomography (CT) with radionuclide imaging (using positron emission tomography (PET) or single-photon emission computed tomography (SPECT)) on a single gantry which allows both functional and structural imaging to be performed during a single imaging session without having the patient leave the imaging system. A SPECT/CT system developed at UCSF is being used in a study to determine if dual-modality imaging offers advantages for assessment of patients with prostate cancer using111 In-ProstaScint®, a radiolabeled antibody for the prostate-specific membrane antigen.111 In-ProstaScint® images are reconstructed using an iterative maximum-likelihood expectation-maximization (ML-EM) algorithm with correction for photon attenuation using a patient-specific map of attenuation coefficients derived from CT. The ML-EM algorithm accounts for the dual-photon nature of the111 In-labeled radionuclide, and incorporates correction for the geometric response of the radionuclide collimator. The radionuclide image then can be coregistered and overlaid in color on a grayscale CT image for improved localization of the functional information from SPECT. Radionuclide images obtained with SPECT/CT and reconstructed using ML-EM with correction for photon attenuation and collimator response improve image quality in comparison to conventional radionuclide images obtained with filtered backprojection reconstruction. These results illustrate the potential advantages of dual-modality imaging for improving the quality and the localization of radionuclide uptake for staging disease, planning treatment, and monitoring therapeutic response in patients with cancer.

In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles

2012 ◽  
Vol 163 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Jaehong Key ◽  
Christy Cooper ◽  
Ah Young Kim ◽  
Deepika Dhawan ◽  
Deborah W. Knapp ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Dual Modality ◽  
Dual Modality Imaging

PA/US dual-modality imaging to guide VEGFR-2 targeted photothermal therapy using ZnPc-/PFH-loaded polymeric nanoparticles

2018 ◽  
Vol 6 (8) ◽  
pp. 2130-2143 ◽  
Author(s):  
Yu-li Chen ◽  
Feng-qiu Liu ◽  
Yuan Guo ◽  
Juan Cheng ◽  
Lu Yang ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Photothermal Therapy ◽  
Polymeric Nanoparticles ◽  
Atherosclerotic Plaques ◽  
Dual Modality ◽  
Pathological Characteristic ◽  
Dual Modality Imaging

Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques.

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