scholarly journals Human Macrophage Invasion: Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior (Adv. Funct. Mater. 28/2021)

2021 ◽  
Vol 31 (28) ◽  
pp. 2170205
Author(s):  
Laura C. Bahlmann ◽  
Alexander E. G. Baker ◽  
Chang Xue ◽  
Sophie Liu ◽  
Moritz Meier‐Merziger ◽  
...  
Keyword(s):  
Human Macrophage ◽  
Invasion Behavior

Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior

2021 ◽  
pp. 2008400
Author(s):  
Laura C. Bahlmann ◽  
Alexander E. G. Baker ◽  
Chang Xue ◽  
Sophie Liu ◽  
Moritz Meier‐Merziger ◽  
...  
Keyword(s):  
Human Macrophage ◽  
Invasion Behavior

Erythropoietin Directly Affects Human Macrophage Functionality

2018 ◽  
Vol 19 (11) ◽  
pp. 902-909 ◽  
Author(s):  
Olga V. Melashchenko ◽  
Maxim E. Meniailo ◽  
Vladimir V. Malashchenko ◽  
Natalya D. Gazatova ◽  
Andrei G. Goncharov ◽  
...  
Keyword(s):  
Human Macrophage

scholarly journals Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 335
Author(s):  
Albert Morales ◽  
Silvia Rojo Rello ◽  
Helena Cristóbal ◽  
Aida Fiz-López ◽  
Elisa Arribas ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Growth Arrest ◽  
Emergency Admission ◽  
Human Macrophage ◽  
Specific Factor ◽  
Alveolar Cells ◽  
Lps Challenge ◽  
Tam Receptors ◽  
Relevant Role ◽  
Severity Of The Disease

Background: Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, and MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for SARS-CoV-2, particularly in the respiratory system, and the GAS6/AXL axis is targeted in current clinical trials against COVID-19. However, GAS6 and TAMs have not been evaluated in COVID-19 patients at emergency admission. Methods: Plasma GAS6, AXL, and MERTK were analyzed in 132 patients consecutively admitted to the emergency ward during the first peak of COVID-19. Results: GAS6 levels were higher in the SARS-CoV-2-positive patients, increasing progressively with the severity of the disease. Patients with initial GAS6 at the highest quartile had the worst outcome, with a 3-month survival of 65%, compared to a 90% survival for the rest. Soluble AXL exhibited higher plasma concentration in deceased patients, without significant differences in MERTK among SARS-CoV-2-positive groups. GAS6 mRNA was mainly expressed in alveolar cells and AXL in airway macrophages. Remarkably, THP-1 human macrophage differentiation neatly induces AXL, and its inhibition (bemcentinib) reduced cytokine production in human macrophages after LPS challenge. Conclusions: Plasma GAS6 and AXL levels reflect COVID-19 severity and could be early markers of disease prognosis, supporting a relevant role of the GAS6/AXL system in the immune response in COVID-19.

Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage

Inflammation ◽  
2018 ◽  
Vol 41 (3) ◽  
pp. 784-794 ◽  
Author(s):  
Yuezhu Zhang ◽  
Shuyue Wang ◽  
Jian Zhu ◽  
Chunyan Li ◽  
Tianrong Zhang ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Human Macrophage ◽  
Expression Levels ◽  
Atmospheric Pm2.5
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