Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization

2020 ◽  
Vol 30 (13) ◽  
pp. 1910168 ◽  
Author(s):  
Aohua Wang ◽  
Weiwei Fan ◽  
Tiantian Yang ◽  
Shufang He ◽  
Yiwei Yang ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Glucose Utilization ◽  
Endogenous Insulin Secretion ◽  
Endogenous Insulin ◽  
Hepatic Glucose

Insulin secretion and substrate homeostasis in prolonged hypothermia in rats

1988 ◽  
Vol 255 (6) ◽  
pp. R1035-R1040
Author(s):  
R. Hoo-Paris ◽  
M. L. Jourdan ◽  
L. C. Wang ◽  
R. Rajotte
Keyword(s):  
Insulin Secretion ◽  
Plasma Glucose ◽  
Low Temperatures ◽  
Plasma Insulin ◽  
Glucose Utilization ◽  
Exogenous Insulin ◽  
Metabolic Substrate ◽  
Endogenous Insulin ◽  
Dose Dependent Decrease ◽  
Dose Dependent

In hypothermia, impairment of metabolic substrate mobilization and utilization may be a factor limiting survival. By use of a newly developed technique, substrate profiles and their regulation by insulin were examined in hypothermic rats (body temperature 19 degrees C) over 24 h. Plasma glucose concentrations increased to approximately 300 mg/dl during cooling and remained high throughout the period of hypothermia. Free fatty acid (FFA) concentration was not altered during cooling or during the first 10 h of hypothermia (approximately 700 mu eq/l) but progressively decreased thereafter, reaching 420 mu eq/l by 20 h. Plasma insulin decreased dramatically during cooling and remained very low (9 +/- 2 microU/ml) during the whole period of hypothermia, reflecting the suppression of insulin secretion by isolated islets at low temperatures. To test he hypothesis that suppression of endogenous insulin secretion may hamper glucose utilization and thus limit survival in hypothermia, exogenous insulin was administered. At doses of 0.1, 0.5, and 1 U/kg intravenously, insulin slowly decreased plasma glucose and FFA. However, at 0.1 and 1 U/kg intraperitoneally, insulin resulted in a dose-dependent decrease in survival time in the hypothermic rat. It is possible that the antilipolytic effect of insulin may have outweighed any beneficial effect of improving glucose utilization in hypothermia.

C-Peptide Clearance: Potential Marker of Endogenous Insulin Secretion for Pkpd Studies of Insulin In Neonates

2015 ◽  
Vol 37 (8) ◽  
pp. e59
Author(s):  
E.R. Salis ◽  
M.K. Soelbeck ◽  
D.M. Reith ◽  
B.J. Wheeler ◽  
R.S. Broadbent ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
C Peptide ◽  
Endogenous Insulin Secretion ◽  
Endogenous Insulin ◽  
Potential Marker
Sign in / Sign up

Export Citation Format

Share Document