scholarly journals Glycated Albumin and Glycated Hemoglobin Are Influenced Differently by Endogenous Insulin Secretion in Patients With Type 2 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 33 (2) ◽  
pp. 270-272 ◽  
Author(s):  
M. Koga ◽  
J. Murai ◽  
H. Saito ◽  
S. Kasayama
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
Endogenous Insulin Secretion ◽  
Endogenous Insulin

scholarly journals Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aika Miya ◽  
Akinobu Nakamura ◽  
Takahisa Handa ◽  
Hiroshi Nomoto ◽  
Hiraku Kameda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Insulin Secretion ◽  
Glucose Monitoring ◽  
Glycemic Variability ◽  
Endogenous Insulin Secretion ◽  
Endogenous Insulin ◽  
Antidiabetic Treatment ◽  
Log Linear

AbstractThe contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endogenous insulin secretion and GV in type 2 diabetes (T2DM), regardless of the type of antidiabetic treatment. We conducted a prospective observational study using continuous glucose monitoring obtained from 284 Japanese outpatients with T2DM with various HbA1c values and antidiabetic treatment. We constructed a prediction curve of base-line CPR versus coefficient of variation (CV) and identified the clinical factors associated with CV using multiple regression analysis. Fasting CPR showed a significant negative log-linear relationship with CV (P < 0.0001), and the latter being strikingly high in the low-CPR group. The multiple regression analysis showed that low CPR was an independent predictor of high CV (P < 0.0001). The significant correlations were sustained in both patients with/without insulin treatment. The contribution of endogenous insulin secretion to GV depends on the extent of insulin secretion impairment. Fasting CPR may represent a useful indicator of GV instability in T2DM.

scholarly journals Effect of Glycosylated Hemoglobin with Microalbuminuria and Albumin Creatinine Ratio in Type 2 Diabetes

2021 ◽  
Vol 15 (7) ◽  
pp. 1974-1977
Author(s):  
Vitasari Indriani ◽  
Wahyu Siswandari ◽  
Andreas . ◽  
Tri Lestari
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Glycated Hemoglobin ◽  
Glycosylated Hemoglobin ◽  
Glycated Albumin ◽  
Diabetes Duration ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Detailed Medical History

Background: Diabetes mellitus has strong correlation with end stage renal disease (ESRD) and responsible for 30-40% of all ESRD cases.This study is focused on assessing the diabetic nephropathy status in patients with type 2 diabetes. Glycated hemoglobin levels over therapeutic targets (>7%) had two times the risk of complications for diabetic nephropathy, ISN recommends the use of microalbuminuria and urinary albumin creatinine ratio (UACR) for early detection of diabetic nephropathy and for monitoring therapy. Objective: This study was conducted to prove the correlation between Glycated Albumin with microalbuminuria and UACR in type 2 diabetes. Methods: Cross sectional study was done in70diabetic type 2 patients who attended PROLANIS program in Primary Health Care from May to November 2018.Detailed medical history including the diabetes duration and relevant clinical examination like FBS, PPBS, HbA1c, urinary creatinineand urinary microalbumin were recorded in each patient.Significance is assessed at 5% level of significance. Results: This study obtained the mean age of the study population was 51.89 ± 6.78 years with female preponderance (51.1%).Mean FBS, PPBS, HbA1c, duration of diabetes, blood pressure, microalbuminuria and urinary creatinine were182.51 ± 74.63 mg/dL, 186.25±26.72 mg/dL, 8.8 ± 1.83%, 9.37±5.96 years, 138.44±14, 13/84.44±19.25 mmHg,30.32±3.2 mg/day and 1.33±0.64 mg/dl respectively.Microalbuminuria (r=0.91, p≤0.05) and UACR (r=0.67, p≤0.05) were positively associated with glycated hemoglobin. Conclusion: It can be concluded that microalbuminuria level and ACR increase in line with the worsening of glycosylated hemoglobin and diabetes duration. Keywords: Albumin Creatinine Ratio; Diabetes; HbA1c; Microalbuminuria

Body mass index negatively regulates glycated albumin through insulin secretion in patients with type 2 diabetes mellitus

2015 ◽  
Vol 438 ◽  
pp. 19-23 ◽  
Author(s):  
Masafumi Koga ◽  
Takumi Hirata ◽  
Soji Kasayama ◽  
Yuko Ishizaka ◽  
Minoru Yamakado
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Body Mass ◽  
Glycated Albumin

scholarly journals Glycated Albumin is a Better Indicator for Glucose Excursion than Glycated Hemoglobin in Type 1 and Type 2 Diabetes

2008 ◽  
Vol 55 (3) ◽  
pp. 503-507 ◽  
Author(s):  
Kazutomi YOSHIUCHI ◽  
Munehide MATSUHISA ◽  
Naoto KATAKAMI ◽  
Yoshihisa NAKATANI ◽  
Kenya SAKAMOTO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
Glucose Excursion
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