Ultraeffective Cancer Therapy with an Antimonene‐Based X‐Ray Radiosensitizer

2019 ◽  
Vol 30 (4) ◽  
pp. 1906010 ◽  
Author(s):  
Yanhong Duo ◽  
Yanyu Huang ◽  
Weiyuan Liang ◽  
Riming Yuan ◽  
Yang Li ◽  
...  
Keyword(s):  
2019 ◽  
Author(s):  
Erh-Hsuan Lin ◽  
Wen-Wong Kuo ◽  
Wan-Ting Tseng ◽  
Chi-Chieh Cheng ◽  
Shih-Feng Tseng ◽  
...  

2013 ◽  
Vol 49 (25) ◽  
pp. 2545 ◽  
Author(s):  
Zane B. Starkewolf ◽  
Larissa Miyachi ◽  
Joyce Wong ◽  
Ting Guo

ACS Nano ◽  
2019 ◽  
Vol 13 (9) ◽  
pp. 10419-10433 ◽  
Author(s):  
Farooq Ahmad ◽  
Xiaoyan Wang ◽  
Zhao Jiang ◽  
Xujiang Yu ◽  
Xinyi Liu ◽  
...  
Keyword(s):  

SPIN ◽  
2019 ◽  
Vol 09 (02) ◽  
pp. 1940003 ◽  
Author(s):  
Milad Salimi Bani ◽  
Shadie Hatamie ◽  
Mohammad Haghpanahi ◽  
Hossein Bahreinizad ◽  
Mohammad Hossein Shahsavari Alavijeh ◽  
...  

Iron oxide nanoparticles (NPs) have been a very appealing choice in magnetic-mediated hyperthermia for cancer therapy. The responses of NPs to hyperthermia as a cancer treatment method are complex and variable. Herein, the heating properties of the casein-coated magnetic NPs (MNPs) under an alternating magnetic field were investigated. The casein-coated MNPs were synthesized via one-pot chemical method. The casein-coated MNPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential, dynamic light scattering (DLS), and vibrating sample magnetometer (VSM) analysis. TEM images of casein-coated MNPs show that their shapes are spherical and their core sizes are between 20[Formula: see text]nm and 25[Formula: see text]nm. The FTIR and EDAX results confirmed the presence of casein on the surface of MNPs. The VSM shows the superparamagnetic nature of iron oxide and casein-coated iron oxide NPs with the magnetic saturation of 60[Formula: see text]emu/g and 44.86[Formula: see text]emu/g, respectively, at room temperature. Furthermore, hyperthermia tests for casein-coated MNPs with various concentrations and frequencies are performed. Hyperthermia results show that lower concentrations of casein-coated MNPs dispatch higher heating into their surrounding medium, whereas maximum specific absorption rate occurs at the concentration of 1[Formula: see text]mg/mL for the frequency of 150[Formula: see text]kHz. Findings of this study suggest that casein-coated MNPs have great potential as an anticancer agent in hyperthermia cancer therapy.


2017 ◽  
Vol 3 (3) ◽  
pp. 035018
Author(s):  
Justus Adamson ◽  
Stewart Mein ◽  
Boyu Meng ◽  
Rathnayaka Gunasingha ◽  
Suk W Yoon ◽  
...  
Keyword(s):  

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162078 ◽  
Author(s):  
Mark Oldham ◽  
Paul Yoon ◽  
Zak Fathi ◽  
Wayne F. Beyer ◽  
Justus Adamson ◽  
...  
Keyword(s):  

2020 ◽  
Vol 45 (1) ◽  
pp. 3-14
Author(s):  
Winston I. Lu ◽  
Dominic P. Lu

The purpose of this research was to proce or disprove the widely held beliefs that X-ray radiation used in medical or dental applications may affect the normal oral flora, and may also have effects on the micro-organisms existing in the oral cavity of every person. Such beliefs might be due to the common knowledge that radiation therapy has been utilized for the long time in the cancer patients to destroy the cancerous cells, and that radiation are also widely used in agriculture to prolong the shelf life of the farm products by destroying the decay-causing microorganisms existing in the agricultural products such as meats, produce, etc. Since very few research has been conducted in this concerned area, and not much pertinent information in the scientific literature could be found in this regard, a research experiment was set up to find out if these common beliefs have any merits. The research experiment involved selecting BDORT(By-digital O-Ring Test) positive dishes to incubate human saliva collected from a volunteer patient. Once dish served as control which was not subjected X-ray irradiation. Other dishes were subjected X-ray irradiation with various doses of irradiation strength at various time interval such as 1, 3, 5, 7, and 9 seconds to find out if any significant change taken place in the bacteria colonies. The bacterial colonies in the irradiated dishes then compared with that of the control dish so as to draw a conclusion if radiation for medical and dental X-ray machines would actually have any bactericidal or/and bacteriostatic effects on the oral micro-organisms flora. Finally, dishes were brought to a local hospital Radiology Department to use high dose of irradaition (used for cancer therapy) on the dishes to find out to what extent if such a high dose X-ray irradiation emitted from therapeutic cancer therapy machine would affect the number of bacterial colonies in the dishes as when compared with when dishes were under low doses of X-ray irradiation from dental or medical diagnostic X-ray machines. During the experiment, dishes, when irradiated, were sent to a certified medical technologist in the hospital laboratory to count the number of the bacterial colonies, and each change in the bacterial colony number were recorded in to data for biostatic analysis. The data were compared with BDORT negativity scores collected each time before and after dishes were irradiated, thus to find out if any corresponding confirmity between traditional laboratory findings and the score changes from BDORT findings. The results of this experiment revealed the fact that radiation from regular diagnostic X-ray machines possess little effect on bacteria, and that they have little effect on both cells and bacteria present in the human body. Neverthless, dramatically increasing the high radiation dosages does have potential to both inhibit and destroy bacteria. Therefore,using irradiation techniques to inhibit bacterial growth is only useful in agriculture practices, since tens of thousands of irradaiation dosages are necessary for bacteria inhibition. in human, over 500 RADs (radiation absorption dose) is lethal. Therefore, bacterial inhibition could not be practical in humans since it requires tens of thousands of RADs to be useful in the aspect.


2019 ◽  
Author(s):  
Erh-Hsuan Lin ◽  
Wen-Wong Kuo ◽  
Wan-Ting Tseng ◽  
Chi-Chieh Cheng ◽  
Shih-Feng Tseng ◽  
...  

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