X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy

2013 ◽  
Vol 49 (25) ◽  
pp. 2545 ◽  
Author(s):  
Zane B. Starkewolf ◽  
Larissa Miyachi ◽  
Joyce Wong ◽  
Ting Guo
Keyword(s):  
Cancer Therapy ◽  
Drug Carriers ◽  
Triggered Release ◽  
X Ray

Hyaluronan based Multifunctional Nano-carriers for Combination Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Menghan Gao ◽  
Hong Deng ◽  
Weiqi Zhang
Keyword(s):  
Cancer Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Functional Sites ◽  
Therapeutic Modalities ◽  
Combination Cancer Therapy ◽  
Targeting Strategy

: Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility, biodegradability, and low immunogenicity, making it one of the most attractive biopolymers used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered to construct different drug-loading nanoparticles (NPs) for CD44- targeted anti-tumor therapy. When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained, which features as a highly effective and self-targeting strategy to combat the cancers with CD44 overexpression. The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many types of HA-based multidrug nano-carriers constructed by different formulation strategies including drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier takes the full advantages of HA as NP matrix, drug carriers and targeting ligand, representing a simplified and biocompatible platform to realize the targeted and synergistic combination therapy against the cancers. In this review, recent progresses about HA-based multidrug nano-carriers for combination cancer therapy are summarized and its potential challenges for translational applications have been discussed.

scholarly journals Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

2010 ◽  
Vol 7 (4) ◽  
pp. 479-495 ◽  
Author(s):  
Mary Caldorera-Moore ◽  
Nathalie Guimard ◽  
Li Shi ◽  
Krishnendu Roy
Keyword(s):  
Drug Carriers ◽  
Triggered Release

X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14627-14634 ◽  
Author(s):  
Fang Liu ◽  
Junzhe Lou ◽  
Dimitre Hristov
Keyword(s):  
Cancer Cells ◽  
Cell Nucleus ◽  
Reactive Nitrogen Species ◽  
Nitrogen Species ◽  
Triggered Release ◽  
X Ray ◽  
Enhanced Sensitivity ◽  
New Strategy ◽  
Targeting Peptide

New strategy to enhance cancer radiotherapy: A novel gold nanosystem with surface-grafted nitroimidazole and cell nucleus-targeting peptide achieves the release of a RNS precursor, nitrite, by ionizing radiation. In vitro radiotherapy shows enhanced sensitivity of hypoxic cancer cells to X-ray radiation, presumably due to the generation of both reactive oxygen and nitrogen species.

scholarly journals Combination Cancer Therapy Using Chimeric Antigen Receptor-Engineered Natural Killer Cells as Drug Carriers

2017 ◽  
Vol 25 (12) ◽  
pp. 2607-2619 ◽  
Author(s):  
Elizabeth L. Siegler ◽  
Yu Jeong Kim ◽  
Xianhui Chen ◽  
Natnaree Siriwon ◽  
John Mac ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cancer Therapy ◽  
Natural Killer ◽  
Chimeric Antigen Receptor ◽  
Antigen Receptor ◽  
Drug Carriers ◽  
Killer Cells ◽  
Combination Cancer Therapy

scholarly journals Stimuli Responsive Polymeric Systems for Cancer Therapy

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 136 ◽  
Author(s):  
Ali Alsuraifi ◽  
Anthony Curtis ◽  
Dimitrios Lamprou ◽  
Clare Hoskins
Keyword(s):  
Cancer Therapy ◽  
Drug Efficacy ◽  
Drug Carriers ◽  
Smart Polymers ◽  
Stimuli Responsive ◽  
Research Focus ◽  
Polymeric Systems ◽  
Effective Strategies ◽  
Targeting Ability ◽  
Patient Side

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature have led to a major boom in research focus. This review article concentrates on the use of these smart polymers in cancer therapy. Nanotechnologies have shown potential as drug carriers leading to increased drug efficacy and penetration. Multifunctional smart carriers which can release their payload upon an external or internal trigger such as pH or temperature are proving to be major frontrunners in the development of effective strategies to overcome this disease with minimal patient side effects.

scholarly journals Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

2020 ◽  
Vol 128 ◽  
pp. 110237 ◽  
Author(s):  
Xiaoyin Zhao ◽  
Dongliang Wu ◽  
Xudong Ma ◽  
Jiale Wang ◽  
Wenjun Hou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Carriers
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