Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

2018 ◽  
Vol 28 (40) ◽  
pp. 1801840 ◽  
Author(s):  
Zhiwen Zhang ◽  
Hong Wang ◽  
Tao Tan ◽  
Jie Li ◽  
Zhiwan Wang ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Tumor Metastasis ◽  
Rational Design ◽  
Tumor Penetration

Enhanced Primary Tumor Penetration Facilitates Nanoparticle Draining into Lymph Nodes after Systemic Injection for Tumor Metastasis Inhibition

ACS Nano ◽  
2019 ◽  
Vol 13 (8) ◽  
pp. 8648-8658 ◽  
Author(s):  
Jing Liu ◽  
Hong-Jun Li ◽  
Ying-Li Luo ◽  
Cong-Fei Xu ◽  
Xiao-Jiao Du ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Primary Tumor ◽  
Tumor Metastasis ◽  
Systemic Injection ◽  
Tumor Penetration ◽  
Metastasis Inhibition

scholarly journals The CC′ loop of IgV domain containing immune checkpoint receptors: From a bystander to an active determinant of receptor:ligand binding

2019 ◽  
Author(s):  
Shankar V. Kundapura ◽  
Udupi A. Ramagopal
Keyword(s):  
Immune Response ◽  
Rational Design ◽  
Immune Checkpoints ◽  
Affinity Modification ◽  
Negative Regulators ◽  
Limited Effect ◽  
Durable Response ◽  
Tumor Penetration ◽  
Affinity Modulation ◽  
Checkpoint Receptors

AbstractAntibodies targeting negative regulators of immune checkpoints have shown unprecedented and durable response against variety of malignancies. While the concept of blocking the negative regulators of immune checkpoints using mAbs appears to be an outstanding approach, their limited effect and several drawbacks such as resistance, poor solid tumor penetration and so on, calls for the rational design of next generation of therapeutics. Soluble isoforms of negative regulators of immune checkpoints are expressed naturally and are shown to regulate the immune response, suggesting the soluble version of these molecules and affinity-modified versions of these self-molecules could be effective lead molecules for immunotherapy. To get a better insight on hotspot regions for modification, we have analysed structures of available immune receptor:ligand complexes containing IgV domains. Interestingly, this analysis reveals that the CC′ loop of IgV domain, a loop which is distinct from CDRs which are generally utilized by antibodies to recognize antigens, plays a pivotal role in affinity modulation. Here, we present several examples of cognate partner specific conformational variation observed in CC′ loop of several checkpoint receptor:ligand complexes. In addition,in silicoswapping of CC′ loop targeting TIGIT:Nectin-2/PVR pathway corroborated well with biophysically determined affinity values for these complexes. Thus, CC′ loop appears to be a hotspot for affinity modification without affecting the specificity to their cognate receptors, an important requirement to avoid unintended interaction of these modified molecules with undesired targets.

Laminin receptor-targeted etoposide loaded polymeric micelles: a novel approach for the effective treatment of tumor metastasis

2011 ◽  
Vol 20 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Mukesh Ukawala ◽  
Kiran Chaudhari ◽  
Tushar Rajyaguru ◽  
A.S. Manjappa ◽  
R.S.R. Murthy ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Tumor Metastasis ◽  
Polymeric Micelles ◽  
Laminin Receptor ◽  
Novel Approach

Rational design of a FRET based nanoprobe of gold conjugated carbon dots for simultaneous monitoring and disruption of Pseudomonas aeruginosa biofilm through selective detection of virulence factor pyocyanin

2021 ◽  
Author(s):  
Chandni Sharma ◽  
Ashish K Shukla ◽  
Amitabha Acharya
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Effective Treatment ◽  
Virulence Factor ◽  
Carbon Dots ◽  
Rational Design ◽  
Selective Detection ◽  
Negative Bacterium ◽  
Gram Negative ◽  
Different Types

Successful and effective treatment of different types of infections depends upon fast and selective identification of the microorganisms. Pseudomonas aeruginosa is a gram-negative bacterium which is involved in number of...

scholarly journals Rational design of non-toxic GOx-based biocatalytic nanoreactor for multimodal synergistic therapy and tumor metastasis suppression

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10001-10011
Author(s):  
Lifeng Hang ◽  
Tao Zhang ◽  
Hua Wen ◽  
Meng Li ◽  
Lianbao Liang ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Rational Design ◽  
Metastasis Suppression

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

Qualitative Examination of Children's Naming Skills through Test Adaptations

1987 ◽  
Vol 18 (3) ◽  
pp. 206-216 ◽  
Author(s):  
Melanie Fried-Oken
Keyword(s):  
Effective Treatment ◽  
Language Disorder ◽  
Treatment Goals ◽  
Expressive Vocabulary ◽  
Qualitative Information ◽  
Word Finding ◽  
Confrontation Naming ◽  
Naming Test

A new procedure entitled the Double Administration Naming Technique is proposed to assist the clinician in obtaining qualitative information about a client's visual confrontation naming skills. It involves the administration of the standard naming test followed by a readministration of the instrument. A series of naming cues then are presented. By examining the number and types of naming errors produced during the two test presentations, the clinician distinguishes word-finding problems from expressive vocabulary limitations and qualitatively describes the language disorder. The cues that facilitate correct naming are used to plan effective treatment goals.

Sign in / Sign up

Export Citation Format

Share Document