scholarly journals Cancer Therapy: Photo-Induced Charge-Variable Conjugated Polyelectrolyte Brushes Encapsulating Upconversion Nanoparticles for Promoted siRNA Release and Collaborative Photodynamic Therapy under NIR Light Irradiation (Adv. Funct. Mater. 44/2017)

2017 ◽  
Vol 27 (44) ◽  
Author(s):  
Hui Zhao ◽  
Wenbo Hu ◽  
Hengheng Ma ◽  
Rongcui Jiang ◽  
Yufu Tang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Light Irradiation ◽  
Upconversion Nanoparticles ◽  
Conjugated Polyelectrolyte ◽  
Polyelectrolyte Brushes ◽  
Nir Light ◽  
Induced Charge

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

Two-Photon-Induced Charge-Variable Conjugated Polyelectrolyte Brushes for Effective Gene Silencing

2019 ◽  
Vol 2 (4) ◽  
pp. 1676-1685 ◽  
Author(s):  
Hui Zhao ◽  
Haojie Tao ◽  
Wenbo Hu ◽  
Xiaofei Miao ◽  
Yufu Tang ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Conjugated Polyelectrolyte ◽  
Polyelectrolyte Brushes ◽  
Two Photon ◽  
Induced Charge

Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy

2018 ◽  
Vol 6 (48) ◽  
pp. 8148-8162 ◽  
Author(s):  
Qi Cai ◽  
Jiating Xu ◽  
Dan Yang ◽  
Yunlu Dai ◽  
Guixin Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Light Irradiation ◽  
Nir Light

Under 980 nm light irradiation, polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposites can convert NIR light to achieve both photodynamic therapy (PDT) and photothermal therapy (PTT).

scholarly journals White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9218-9222
Author(s):  
Jiamei Liang ◽  
Pan Wu ◽  
Chunyan Tan ◽  
Yuyang Jiang
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
White Light ◽  
Cell Apoptosis ◽  
Light Irradiation ◽  
Conjugated Polyelectrolyte ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

A conjugated polyelectrolyte PPET3 functions as an efficient photosensitizer for photodynamic therapy and induces cell apoptosis under white light irradiation.

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

scholarly journals Aggregation-Induced Emission (AIE) Polymeric Micelles for Imaging-Guided Photodynamic Cancer Therapy

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 921 ◽  
Author(s):  
Yang Zhang ◽  
Cai-Xia Wang ◽  
Shi-Wen Huang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Plasma Membranes ◽  
Polymeric Micelles ◽  
Light Irradiation ◽  
Emission Characteristic ◽  
Noninvasive Treatment ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Photodynamic therapy (PDT) is a noninvasive treatment for selectively killing malignant tumor cells. The photosensitizer is a necessary component of photodynamic nanomedicine. Many efforts have been made to develop new photosensitizers for efficient cancer photodynamic therapy. In this work, we report a novel nano photosensitizer, polymeric micelles (AIE-M) with aggregation induced emission characteristic, for photodynamic cancer therapy. AIE-M with sub-20 nm particle size is prepared by the self-assembly of salicylaldazine-incorporated amphiphilic polymer (AIE-1), which can produce reactive oxygen species (ROS) with light irradiation in solution. After uptake by cancer cells, AIE-M can specially sojourn in plasma membranes of cancer cells at the early stage and predominantly accumulate in the mitochondria of cancer cell at the late stage. The phototoxicity of AIE-M, resulting from the generation of intracellular ROS with light irradiation, can efficiently cause cancer cells death by apoptosis and necrosis. The advantages of AIE-M as a nano photosensitizer include the small size, highly colloidal stability in the process of preparation and storage, and high cell penetration. The ultra-low Critical Micelle Concentration (CMC) of AIE-1, negligible dark toxicity and super phototoxicity of AIE-M suggest its promising potential for image-guided PDT.

Single Molecular Nanomedicine with NIR Light-Initiated Superoxide Radical, Singlet Oxygen and Thermal Generation for Hypoxia‐Overcoming Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jipsa Chelora ◽  
Yuchao Liang ◽  
Wei-Chih Wei ◽  
Xiao Cui ◽  
Yafang XIAO ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Short Wavelength ◽  
Superoxide Radical ◽  
Low Oxygen ◽  
Tissue Penetration ◽  
Thermal Generation ◽  
Nir Light ◽  
Recent Attention

While photodynamic therapy (PDT) of cancer has attracted much recent attention, its general applications are limited by shallow tissue penetration depth of short-wavelength photons and the low oxygen contents in...

Sign in / Sign up

Export Citation Format

Share Document