High-Drug-Loading Mesoporous Silica Nanorods with Reduced Toxicity for Precise Cancer Therapy against Nasopharyngeal Carcinoma

2017 ◽  
Vol 27 (42) ◽  
pp. 1703313 ◽  
Author(s):  
Yuanyuan You ◽  
Lizhen He ◽  
Bin Ma ◽  
Tianfeng Chen
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
High Drug ◽  
Reduced Toxicity ◽  
High Drug Loading ◽  
Silica Nanorods

Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy

2020 ◽  
Vol 8 (3) ◽  
pp. 949-959 ◽  
Author(s):  
Yuchen Wu ◽  
Shixian Lv ◽  
Yongjuan Li ◽  
Hua He ◽  
Yong Ji ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
High Drug ◽  
Delivery Strategy ◽  
Anti Cancer ◽  
High Drug Loading

The introduction of donor-receptor coordination between micelles and drug payloads provides a precise co-delivery strategy for two different chemo-drugs with high drug loading and ROS responsiveness.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity

2013 ◽  
Vol 42 (24) ◽  
pp. 8918 ◽  
Author(s):  
Baixiang Wang ◽  
Weiyan Meng ◽  
Ming Bi ◽  
Yuxin Ni ◽  
Qing Cai ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
Hollow Spheres ◽  
Magnesium Silicate ◽  
Systemic Toxicity ◽  
High Drug ◽  
High Drug Loading

Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 235-244 ◽  
Author(s):  
Shuo Fang ◽  
Yongpeng Hou ◽  
Longbing Ling ◽  
Danquan Wang ◽  
Muhammad Ismail ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

A ROS-scavenging multifunctional nanoparticle for combinational therapy of diabetic nephropathy

Nanoscale ◽  
2020 ◽  
Vol 12 (46) ◽  
pp. 23607-23619
Author(s):  
Yuna Tong ◽  
Lijuan Zhang ◽  
Rong Gong ◽  
Jianyou Shi ◽  
Lei Zhong ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Loading Capacity ◽  
Ros Scavenging ◽  
High Drug ◽  
Combinational Therapy ◽  
Multifunctional Nanoparticle ◽  
Hollow Mesoporous Silica ◽  
High Drug Loading

A renoprotective activity hollow mesoporous silica nanocomposite (HMSN) particle doped with trace cerium oxide has been constructed, which not only has the ability to prevent ROS-associated DN pathogenesis but also has high drug loading capacity.

scholarly journals Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

2020 ◽  
Vol 6 (45) ◽  
pp. eabc1725
Author(s):  
Yinxian Yang ◽  
Bingjun Sun ◽  
Shiyi Zuo ◽  
Ximu Li ◽  
Shuang Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Rational Design ◽  
Colloidal Stability ◽  
Drug Loading ◽  
High Drug ◽  
Tumor Selectivity ◽  
Poor Stability ◽  
High Drug Loading

Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug loading, poor stability, and poor tumor selectivity. Here, we report that simple insertion of a trisulfide bond can turn doxorubicin homodimeric prodrugs into self-assembled nanoparticles with three benefits: high drug loading (67.24%, w/w), high self-assembly stability, and high tumor selectivity. Compared with disulfide and thioether bonds, the trisulfide bond effectively promotes the self-assembly ability of doxorubicin homodimeric prodrugs, thereby improving the colloidal stability and in vivo fate of prodrug nanoassemblies. The trisulfide bond also shows higher glutathione sensitivity compared to the conventional disulfide bond, and this sensitivity enables efficient tumor-specific drug release. Therefore, trisulfide bond–bridged prodrug nanoassemblies exhibit high selective cytotoxicity on tumor cells compared with normal cells, notably reducing the systemic toxicity of doxorubicin. Our findings provide new insights into the design of advanced redox-sensitive nano-DDS for cancer therapy.

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