Electrospun Extracellular Matrix: Paving the Way to Tailor-Made Natural Scaffolds for Cardiac Tissue Regeneration

2017 ◽  
Vol 27 (34) ◽  
pp. 1700427 ◽  
Author(s):  
Beth Schoen ◽  
Ron Avrahami ◽  
Limor Baruch ◽  
Yael Efraim ◽  
Idit Goldfracht ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
The Way

scholarly journals Cardiac Fibroblast-Derived Extracellular Matrix (Biomatrix) as a Model for the Studies of Cardiac Primitive Cell Biological Properties in Normal and Pathological Adult Human Heart

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Clotilde Castaldo ◽  
Franca Di Meglio ◽  
Rita Miraglia ◽  
Anna Maria Sacco ◽  
Veronica Romano ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Human Heart ◽  
Cardiac Tissue ◽  
Biological Properties ◽  
Cardiac Fibroblast ◽  
Primitive Cell ◽  
Matricellular Proteins ◽  
Adult Human ◽  
Pathological Conditions

Cardiac tissue regeneration is guided by stem cells and their microenvironment. It has been recently described that both cardiac stem/primitive cells and extracellular matrix (ECM) change in pathological conditions. This study describes the method for the production of ECM typical of adult human heart in the normal and pathological conditions (ischemic heart disease) and highlights the potential use of cardiac fibroblast-derived ECM forin vitrostudies of the interactions between ECM components and cardiac primitive cells responsible for tissue regeneration. Fibroblasts isolated from adult human normal and pathological heart with ischemic cardiomyopathy were cultured to obtain extracellular matrix (biomatrix), composed of typical extracellular matrix proteins, such as collagen and fibronectin, and matricellular proteins, laminin, and tenascin. After decellularization, this substrate was used to assess biological properties of cardiac primitive cells: proliferation and migration were stimulated by biomatrix from normal heart, while both types of biomatrix protected cardiac primitive cells from apoptosis. Our model can be used for studies of cell-matrix interactions and help to determine the biochemical cues that regulate cardiac primitive cell biological properties and guide cardiac tissue regeneration.

scholarly journals Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 386
Author(s):  
Ana Santos ◽  
Yongjun Jang ◽  
Inwoo Son ◽  
Jongseong Kim ◽  
Yongdoo Park
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Computational Modeling ◽  
Cardiac Tissue ◽  
Cardiac Development ◽  
Heart Tissue ◽  
Cardiac Tissue Engineering ◽  
Cardiac Cells

Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering.

scholarly journals Extracellular matrix‐based scaffolding technologies for periodontal and peri‐implant soft tissue regeneration

2019 ◽  
Vol 91 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Lorenzo Tavelli ◽  
Michael K. McGuire ◽  
Giovanni Zucchelli ◽  
Giulio Rasperini ◽  
Stephen E. Feinberg ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Carbon nanotubes for cardiac tissue regeneration: State of the art and perspectives

Carbon ◽  
2021 ◽  
Vol 184 ◽  
pp. 641-650
Author(s):  
Myriam Barrejón ◽  
Silvia Marchesan ◽  
Nuria Alegret ◽  
Maurizio Prato
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
State Of The Art

GAG Multivalent Systems to interact with Langerin

2021 ◽  
Vol 28 ◽  
Author(s):  
Javier Rojo ◽  
Pedro M. Nieto ◽  
José Luis de Paz
Keyword(s):  
Extracellular Matrix ◽  
Cell Membrane ◽  
Langerhans Cells ◽  
Pivotal Role ◽  
Monomeric Form ◽  
Recognition Sites ◽  
Interaction Processes ◽  
Carbohydrate Ligands ◽  
The Way

: Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role in protecting organisms against pathogen infections. To address this aim, Langerin presents at least two recognition sites, one Ca2+-dependent and another one independent, capable of recognizing a variety of carbohydrate ligands. In contrast to other lectins, Langerin recognizes sulfated glycosaminoglycans (GAGs), a family of complex and heterogeneous polysaccharides present in the cell membrane and the extracellular matrix at the interphase generated in the trimeric form of Langerin but absent in the monomeric form. The complexity of these oligosaccharides has impeded the development of well-defined monodisperse structures to study these interaction processes. However, in the last few decades, an improvement of synthetic developments to achieve the preparation of carbohydrate multivalent systems mimicking the GAGs has been described. Despite all these contributions, very few examples are reported where the GAG multivalent structures are used to evaluate the interaction with Langerin. These molecules should pave the way to explore these GAG-Langerin interactions.

scholarly journals 0190 : Ephrin-B1 blocks adult cardiomyocyte proliferation and cardiac tissue regeneration

2015 ◽  
Vol 7 (2) ◽  
pp. 198-199
Author(s):  
Celine Mias ◽  
Gael Genet ◽  
Celine Guilbeau-Frugier ◽  
Marie-Helene Seguelas ◽  
Denis Calise ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Cardiac Tissue ◽  
Cardiomyocyte Proliferation

Biomimetic Porous PLGA Scaffolds Incorporating Decellularized Extracellular Matrix for Kidney Tissue Regeneration

2016 ◽  
Vol 8 (33) ◽  
pp. 21145-21154 ◽  
Author(s):  
Eugene Lih ◽  
Ki Wan Park ◽  
So Young Chun ◽  
Hyuncheol Kim ◽  
Tae Gyun Kwon ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Kidney Tissue ◽  
Decellularized Extracellular Matrix

Extracellular matrix scaffold-immune microenvironment modulates tissue regeneration

2021 ◽  
pp. 109524
Author(s):  
Yaling Yu ◽  
Weiying Zhang ◽  
Xuanzhe Liu ◽  
Hongshu Wang ◽  
Junjie Shen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Immune Microenvironment ◽  
Extracellular Matrix Scaffold
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