scholarly journals Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration

2018 ◽  
Vol 22 (3) ◽  
pp. 302-305 ◽  
Author(s):  
Laura E. Niklason
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Tissue Regeneration ◽  
Enhance Stem Cell

scholarly journals Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Jiawen Chen ◽  
Tianyu Sun ◽  
Yan You ◽  
Buling Wu ◽  
Xiaofang Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Surface ◽  
Tissue Regeneration ◽  
Regulatory Network ◽  
Recent Progress ◽  
Bone Tissue Regeneration ◽  
Self Renewal ◽  
Cell Homeostasis

Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.

Enhanced Structure and Function of Stem Cell-Derived Beta-Like Cells Cultured on Extracellular Matrix

2020 ◽  
Author(s):  
Reena Singh ◽  
Richard Tan ◽  
Clara Tran ◽  
Thomas Loudovaris ◽  
Helen E. Thomas ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Structure And Function ◽  
And Function ◽  
Cells Cultured

Recent Advances in Extracellular Matrix for Engineering Stem Cell Responses

2019 ◽  
Vol 26 (34) ◽  
pp. 6321-6338 ◽  
Author(s):  
Shuaimeng Guan ◽  
Kun Zhang ◽  
Jingan Li
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Attachment ◽  
Biological Significance ◽  
Engineering Application ◽  
Advanced Medical Technology ◽  
Challenges And Opportunities ◽  
Physical Functions ◽  
Differential Ability

Stem cell transplantation is an advanced medical technology, which brings hope for the treatment of some difficult diseases in the clinic. Attributed to its self-renewal and differential ability, stem cell research has been pushed to the forefront of regenerative medicine and has become a hot topic in tissue engineering. The surrounding extracellular matrix has physical functions and important biological significance in regulating the life activities of cells, which may play crucial roles for in situ inducing specific differentiation of stem cells. In this review, we discuss the stem cells and their engineering application, and highlight the control of the fate of stem cells, we offer our perspectives on the various challenges and opportunities facing the use of the components of extracellular matrix for stem cell attachment, growth, proliferation, migration and differentiation.

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