A Triple-Collaborative Strategy for High-Performance Tumor Therapy by Multifunctional Mesoporous Silica-Coated Gold Nanorods

2016 ◽  
Vol 26 (24) ◽  
pp. 4339-4350 ◽  
Author(s):  
Guo-Feng Luo ◽  
Wei-Hai Chen ◽  
Qi Lei ◽  
Wen-Xiu Qiu ◽  
Yu-Xin Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Gold Nanorods ◽  
High Performance ◽  
Tumor Therapy

High-Performance Dual Combination Therapy for Cancer Treatment with Hybrid Membrane-Camouflaged Mesoporous Silica Gold Nanorods

2020 ◽  
Vol 12 (52) ◽  
pp. 57732-57745
Author(s):  
Huan Li ◽  
Qingsheng Peng ◽  
Langyu Yang ◽  
Yinshan Lin ◽  
Sheng Chen ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Gold Nanorods ◽  
High Performance ◽  
Hybrid Membrane

An emerging dual collaborative strategy for high-performance tumor therapy with mesoporous silica nanotubes loaded with Mn3O4

2016 ◽  
Vol 4 (46) ◽  
pp. 7406-7414 ◽  
Author(s):  
Yi Zhang ◽  
Jieqiong Tan ◽  
Mei Long ◽  
Huaming Yang ◽  
Shuwen Yuan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
High Performance ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Silica Nanotubes ◽  
Weighted Magnetic Resonance Imaging

A highly integrated nanocomposite is constructed based on mesoporous silica nanotubes (SiNTs)-loaded with Mn3O4 nanoparticles for cervical cancer therapy via T1-weighted magnetic resonance imaging and doxorubicin-based chemotherapy.

A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

2020 ◽  
Vol 8 (42) ◽  
pp. 9686-9696
Author(s):  
Genhua Liu ◽  
Huining Liang ◽  
Ye He ◽  
Lu Lu ◽  
Lu Wang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Gold Nanorods ◽  
Tumor Therapy

A biocompatible nanocomposite of mesoporous silica-coated gold nanorods is fabricated for synergistic tumor therapy.

Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo

Langmuir ◽  
2014 ◽  
Vol 30 (26) ◽  
pp. 7867-7877 ◽  
Author(s):  
Liangliang Dai ◽  
Jinghua Li ◽  
Beilu Zhang ◽  
Junjie Liu ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Redox Responsive

scholarly journals A Study on Mesoporous Silica Loaded With Novel Photosensitizers HCE6 and Oxaliplatin for the Treatment of Cholangiocarcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Pei-Jian Zhang ◽  
Meng-Dong Liu ◽  
Fang-Yong Fan ◽  
Ke-Xia Liu
Keyword(s):  
Mesoporous Silica ◽  
High Performance ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Formation ◽  
Tunel Staining ◽  
Mouse Tumor ◽  
Related Factors ◽  
Killing Effect ◽  
Transmission Electron ◽  
Apoptotic Factors

PurposeCholangiocarcinoma (CCA) is a malignant tumor with a high incidence. The therapeutic effect of conventional chemotherapy and radiotherapy is not obvious. Photodynamic therapy (PDT) is an ideal modality to fight cancer, and the nature of photosensitizer limits its application in clinical therapy. The aim of this study was to explore a novel mode of drug delivery for the intervention of bile duct cancer.MethodsOxaliplatin and photosensitizer HCE6 were loaded with mesoporous silica nanoparticles (MSNs) to synthesize Oxaliplatin/HCE6-MSNs (OH-MSNs); the structure of OH-MSNs was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS), the drug release rate was detected by high performance liquid chromatography; the cellular activity, apoptosis level, and the expression levels of intracellular apoptosis and autophagy-related factors of OH-MSNs on cholangiocarcinoma cells were observed by CCK-8, flow cytometry, colony formation assay, and Western blot; the effects of OH-MSNs on cholangioma growth were observed by mouse tumor formation, immunohistochemistry, and tissue Tunel staining.ResultsThe release of OH-MSNs to Oxaliplatin was enhanced under acidic conditions; compared with Oxaliplatin or O-MSNs, OH-MSNs showed more potent killing effects against cholangiocarcinoma cells (P<0.05), and exerted notably inhibitory effects on the activity of cholangiocarcinoma cells (P<0.05), promoted their apoptosis (P<0.05), and greatly facilitated the expression of pro-apoptotic factors and autophagic factors in cholangiocarcinoma cells (P<0.05), and markedly inhibited the expression of anti-apoptotic factors and autophagic inhibitory factors (P<0.05); moreover, OH-MSNs could significantly suppress the growth of mouse cholangiocarcinoma (P<0.05) and induce apoptosis of tumor cells compared with Oxaliplatin or O-MSNs (P<0.05).ConclusionMSNs loading greatly increases the killing effect of Oxaliplatin on cholangiocarcinoma cells and upgrades the autophagic level of cholangiocarcinoma cells, while OH-MSNs synthesized by further loading HCE6 have a more apparent killing effect on cholangiocarcinoma cells.

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