An emerging dual collaborative strategy for high-performance tumor therapy with mesoporous silica nanotubes loaded with Mn3O4

2016 ◽  
Vol 4 (46) ◽  
pp. 7406-7414 ◽  
Author(s):  
Yi Zhang ◽  
Jieqiong Tan ◽  
Mei Long ◽  
Huaming Yang ◽  
Shuwen Yuan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
High Performance ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Silica Nanotubes ◽  
Weighted Magnetic Resonance Imaging

A highly integrated nanocomposite is constructed based on mesoporous silica nanotubes (SiNTs)-loaded with Mn3O4 nanoparticles for cervical cancer therapy via T1-weighted magnetic resonance imaging and doxorubicin-based chemotherapy.

scholarly journals Impact of diffusion weighted magnetic resonance imaging in diagnosis of cervical cancer

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Sahar Mahmoud Abd elsalam ◽  
Omnia Mokhtar ◽  
Lamia Adel ◽  
Reda Hassan ◽  
Manal Ibraheim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging

scholarly journals The Value of Diffusion-Weighted Magnetic Resonance Imaging in Predicting the Efficacy of Radiation and Chemotherapy in Cervical Cancer

2018 ◽  
Vol 13 (1) ◽  
pp. 305-311 ◽  
Author(s):  
Jingjing Chen ◽  
Hui Hua ◽  
Jing Pang ◽  
Xianglong Shi ◽  
Weiqun Bi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Tumor Diameter ◽  
Resonance Imaging ◽  
Adc Value ◽  
Apparent Diffusion ◽  
Maximum Tumor Diameter ◽  
Weighted Magnetic Resonance Imaging

AbstractBackgroundTo analyze the application value of apparent diffusion coefficient (ADC) and exponent apparent diffusion coefficient (EADC) in evaluating the efficacy of radiation and chemotherapy in cervical cancer using pre- and posttreatment diffusion-weighted magnetic resonance imaging (DW-MRI) scans.Methods52 patients with cervical cancer were administered radiation and chemotherapy. Both MRI and DW-MRI were obtained at different stages. The ADC and EADC values, as well as the maximum tumor diameter, were measured and analyzed.ResultsWe found that the ADC value increased after treatment, and the EADC value decreased. Changes in the calculated ADC occurred earlier than the morphologic changes of the tumors. A negative correlation was detected between reduced rates in the maximum tumor diameter two months after treatment and pretreatment ADC value (r = –0.658, P < 0.05). An ROC curve and nonlinear regression analysis showed that the formula, y = (1525500.122x2 – 4689.962x + 3.482) × 100%, can be used to calculate the percentage of complete remission after treatment according to the pretreatment ADC value.ConclusionOur data suggest that pretreatment ADC and EADC values are predictive of the efficacy of radiation and chemotherapy. Both ADC and EADC values during treatment were instrumental in early monitoring and dynamic observation.

Theranostic nanoscale coordination polymers for magnetic resonance imaging and bisphosphonate delivery

2014 ◽  
Vol 2 (46) ◽  
pp. 8249-8255 ◽  
Author(s):  
Demin Liu ◽  
Chunbai He ◽  
Christopher Poon ◽  
Wenbin Lin
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Coordination Polymers ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging ◽  
Nanoscale Coordination Polymers

Mn-zoledronate NCP carries 63 wt% of zoledronate for cancer therapy and 13 wt% of Mn2+ for T1-weighted magnetic resonance imaging.

Diffusion-weighted magnetic resonance imaging of cervical cancer

2011 ◽  
Vol 18 (4) ◽  
pp. 139-146
Author(s):  
Vaida ATSTUPĖNAITĖ ◽  
Algidas BASEVIČIUS ◽  
Adrijus KRIMELIS ◽  
Artūras INČIŪRA ◽  
Daiva VAITKIENĖ
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Chemoradiation Therapy ◽  
Cervical Tissue ◽  
Resonance Imaging ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
The Mean

Background. Diffusion-weighted magnetic resonance imaging (DW–MRI) has been employed in the diagnostics of malignant tumors of abdomen and pelvis relatively recently. Nowadays, there exists a particular interest in adaptation DW–MRI for assessing the response of tumors to chemoradiaton therapy. The aim of our study was to compare the mean value of the apparent diffusion coefficient (ADC) in a healthy cervix, cancer-affected cervix and a cervix after chemoradiation therapy, as well as to identify the ADC range typical of cervical cancer. Materials and methods. The study enrolled 108 female patients who underwent pelvic MRI in the Lithuanian University of Health Sciences Kaunas Clinics Hospital in 2008–2010. The study group consisted of 65 patients in whom cervical cancer had been clinically suspected and confirmed by biopsy before MRI examination. All these patients underwent pelvic MRI twice: before the chemoradiation therapy and 6 months after the therapy. The control group consisted of 43 patients in whom cervical cancer had been not suspected and MRI was performed because of other pelvic diseases. Results. The mean ADC value of the study group (0.658 ± 0.118 × 10–3 mm2/s) was lower than of the control group (1.171 ± 0.143 × 10–3 mm2/s) (t = 20.315, p = 0.03). The ADC threshold value of 0.945 × 10–3 mm2/s was defined, differentiating the cancer-affected cervical tissue from the normal. The mean ADC value of the patients who responded to chemoradiation therapy (1.111 ± 0.138 × 10–3 mm2/s) increased and in those who did not respond it remained lower (0.733 ± 0.073 × 10–3 mm2/s) (t = 9.518, p = 0.04). The ADC threshold value of 0.830 × 10–3 mm2/s was defined, differentiating the residual tumor tissue from the healthy cervical tissue after chemoradiation therapy. Conclusions. The ADC value in the case of cervical cancer was significantly lower than in the non-affected cervical tissue. The ADC value increases after effective chemoradiation therapy and becomes closer to the coefficient value of non-affected cervical tissue, but still remains lower. The 0.945 × 10–3 mm2/s ADC threshold was detected while differentiating between cancer-affected and normal cervical tissues, while the ADC threshold was 0.830 × 10–3 mm2/s when differentiating between residual tumor tissue and healthy cervical tissue after chemoradiation therapy at a high sensitivity and specificity. Keywords: diffusion-weighted magnetic resonance imaging, apparent diffusion coefficient, cervical cancer, chemoradiation therapy

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