Water-Soluble Poly(N-isopropylacrylamide)-Graphene Sheets Synthesized via Click Chemistry for Drug Delivery

2011 ◽  
Vol 21 (14) ◽  
pp. 2754-2763 ◽  
Author(s):  
Yongzheng Pan ◽  
Hongqian Bao ◽  
Nanda Gopal Sahoo ◽  
Tongfei Wu ◽  
Lin Li
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Water Soluble ◽  
Graphene Sheets ◽  
Soluble Poly

Multiple strategies to produce lipophilic nanoparticles leaving water-soluble poly(HPMA)

RSC Advances ◽  
2015 ◽  
Vol 5 (83) ◽  
pp. 67475-67484 ◽  
Author(s):  
Raffaele Ferrari ◽  
Marco Callari ◽  
Davide Moscatelli
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
Produce Water ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Multiple Strategies ◽  
Hydroxypropyl Methacrylamide ◽  
Drug Delivery Applications ◽  
Soluble Poly

N-(2-Hydroxypropyl) methacrylamide (HPMA) is used to produce water-soluble polymers with non-immumogenic properties that can be used in drug delivery applications.

Water soluble octa-functionalized POSS: all-click chemistry synthesis and efficient host–guest encapsulation

2014 ◽  
Vol 50 (63) ◽  
pp. 8712-8714 ◽  
Author(s):  
Jin Han ◽  
Yaochen Zheng ◽  
Shuai Zheng ◽  
Sipei Li ◽  
Tiannan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Water Soluble ◽  
Multifunctional Platform

Water soluble octa-functional POSSs were readily synthesized via all-click chemistry, affording a precise multifunctional platform for host–guest encapsulation and drug-delivery.

Water-Soluble Poly(ε-caprolactone)-Paclitaxel Prodrugs Toward an Efficient Drug Delivery System

2015 ◽  
Vol 68 (7) ◽  
pp. 1136 ◽  
Author(s):  
Ji Wang ◽  
Huanjiao Sun ◽  
Deshan Li ◽  
Jie Yuan ◽  
Xuefei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Reaction ◽  
Water Soluble ◽  
Antitumour Effect ◽  
High Drug ◽  
Mercaptosuccinic Acid ◽  
Carboxylic Groups ◽  
Mtt Assays ◽  
Soluble Poly ◽  
Mcf 7

In this paper, poly(ϵ-caprolactone)-graft-carboxylic acid (P(α-C2CL)) was prepared via a thio-bromo click reaction between mercaptosuccinic acid and poly(α-bromo-ϵ-caprolactone). It is readily soluble in aqueous solutions (pH 5.5–9.8) due to the presence of carboxylic groups in each repeating unit. A series of water-soluble P(α-C2CL)-paclitaxel prodrugs with high drug contents (up to 41.4 wt-%) was prepared by esterification. Meanwhile, methyl tetrazolium (MTT) assays showed that P(α-C2CL)-paclitaxel prodrugs exhibited a high antitumour effect on A549 and MCF-7 cells. These prodrugs have appeared as a highly versatile and potent platform for cancer therapy.

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

Development of Solid-Self Micron Emulsifying Drug Delivery Systems

2013 ◽  
Vol 6 (2) ◽  
pp. 2014-2021
Author(s):  
Preethi Sudheer ◽  
Koushik Y ◽  
Satish P ◽  
Uma Shankar M S ◽  
R S Thakur
Keyword(s):  
Drug Delivery ◽  
Systemic Circulation ◽  
Water Soluble ◽  
Future Research ◽  
Steady Increase ◽  
Liquid Form ◽  
Lipophilic Compounds ◽  
Modern Drug ◽  
Pharmaceutical Scientist ◽  
Pharmacologically Active

As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble and solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. It is a great challenge for pharmaceutical scientist to convert those molecules into orally administered formulation with sufficient bioavailability.  Among the several approaches to improve oral bioavailability of these molecules, Self-micron emulsifying drug delivery system (SMEDDS) is one of the approaches usually used to improve the bioavailability of hydrophobic drugs. However, conventional SMEDDS are mostly prepared in a liquid form, which can have several disadvantages. Accordingly, solid SMEDDS (S-SMEDDS) prepared by solidification of liquid/semisolid self-micron emulsifying (SME) ingredients into powders have gained popularity. This article provides an overview of the recent advancements in S-SMEDDS such as methodology, techniques and future research directions.

Recent Advances in Novasome Formulation Technology

2014 ◽  
Vol 7 (2) ◽  
pp. 2407-2411
Author(s):  
J M Shah ◽  
N.H Shah ◽  
Hadiya P D
Keyword(s):  
Drug Delivery ◽  
Effective Means ◽  
Entrapment Efficiency ◽  
Bilayer Membrane ◽  
Water Soluble ◽  
Delivery Methods ◽  
Liposomal Drug ◽  
Pharmaceutical Technology ◽  
Insoluble Drugs ◽  
Novel Drug

Pharmaceutical technology has developed various newer modes of novel drug delivery aspects. Modifications in the previously existing drug delivery methods have led to various newly innovated technologies serving as a safe and effective means of improvement over the existing ones. Novasome technology is one of the new innovations of liposomes which have solved many of the problems related to liposomal drug delivery system. It offers a seven bilayer membrane which has the ability to incorporate both water soluble and insoluble drugs. It has an excellent entrapment efficiency which provides better medication. Formulation of novasomes is achieved in a high shear device. Due to its numerous advantages, novasomes have been used extensively in various fields like cosmetics, chemical, personal care, foods, pharmaceuticals and agrochemicals.

Self Microemulsifying Nutraceutical and Drug Delivery Systems

2014 ◽  
Vol 7 (3) ◽  
pp. 2520-2528 ◽  
Author(s):  
Vikrant P Wankhade ◽  
Nivedita S Kale ◽  
K.K Tapar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ternary Phase Diagram ◽  
Aqueous Solubility ◽  
Oral Formulation ◽  
Water Soluble ◽  
Drug Dissolution ◽  
The Novel ◽  
Peristaltic Movement

Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant, and co solvent and sometimes co surfactant. Drug is directly dispersed into the entire gastro intestinal tract with continuous peristaltic movement and drug is available in the solution form of microemulsion, absorbed through lymphatic system and bypasses the dissolution step. Hence they increase the patient compliance. The excipients are selected on basis of construction of ternary phase diagram. Self micro-emulsifying drug delivery system is very useful for drug in which drug dissolution is rate limiting step. This review describes the novel approaches and evaluation parameters of the self microemulsifying drug delivery system towards different classic drugs, proteins-peptides, and nutraceuticals in various oral microemulsion compositions and microstructures.

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