Multiple strategies to produce lipophilic nanoparticles leaving water-soluble poly(HPMA)

RSC Advances ◽  
2015 ◽  
Vol 5 (83) ◽  
pp. 67475-67484 ◽  
Author(s):  
Raffaele Ferrari ◽  
Marco Callari ◽  
Davide Moscatelli
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
Produce Water ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Multiple Strategies ◽  
Hydroxypropyl Methacrylamide ◽  
Drug Delivery Applications ◽  
Soluble Poly

N-(2-Hydroxypropyl) methacrylamide (HPMA) is used to produce water-soluble polymers with non-immumogenic properties that can be used in drug delivery applications.

scholarly journals Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery

2011 ◽  
Vol 61 (2) ◽  
pp. 157-170 ◽  
Author(s):  
Ayrivan Puratchikody ◽  
Viswanadhan Prasanth ◽  
Sam Mathew ◽  
Balaraman Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Water Soluble ◽  
Salbutamol Sulfate ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Peg 400 ◽  
Buccal Drug Delivery ◽  
Full Factorial

Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated patches ranged between 0.2 and 0.4 mm and showed an increase in mass whenever PEG-400 was used as plasticizer. The surface pH of all patches approached neutral. Eight formulations which had shown high folding endurance (> 300) were selected for evaluation. Patches prepared with PEG-400 showed a high swelling index. The residence time of the tested patches ranged between 105 and 130 min. Formulations A10, A32, B10 and B32 fitted the Higuchi model best, whereas formulations A19 and B19 showed super case II transport drug release. Stability studies indicated that there was no change in the chemical and physical characteristics during the test period of 6 months.

Mathematical Modeling of Hyperbranched Water-soluble Polymers with Applications in Drug Delivery

2011 ◽  
Vol 5 (9-10) ◽  
pp. 373-384 ◽  
Author(s):  
Amin Zargar ◽  
Kai Chang ◽  
Lakeshia J. Taite ◽  
F. Joseph Schork
Keyword(s):  
Mathematical Modeling ◽  
Drug Delivery ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers

Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck

2005 ◽  
Vol 13 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Anjan Nan ◽  
Hamidreza Ghandehari ◽  
Carla Hebert ◽  
Hessam Siavash ◽  
Nikolaos Nikitakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Head And Neck ◽  
Targeted Drug Delivery ◽  
Squamous Carcinoma ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Targeted Drug

Modeling of Highly Branched Water-Soluble Polymers with Applications to Drug Delivery Model Extensions and Validation

2015 ◽  
Vol 9 (6) ◽  
pp. 545-555
Author(s):  
Seung Yeon Kim ◽  
Robert Van Dyke ◽  
Kai Chang ◽  
Lakeshia J. Taite ◽  
Francis Joseph Schork
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Delivery Model ◽  
Soluble Polymers
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