scholarly journals Expanded Autoantibody Profiles for Subsetting of Native American, African American, and European American Patients With Systemic Lupus Erythematosus

2020 ◽  
Vol 2 (7) ◽  
pp. 415-423
Author(s):  
Carla J. Guthridge ◽  
Timothy Gross ◽  
Magdalene Quintero ◽  
Joseph M. Kheir ◽  
Jeremy Levin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
Native American ◽  
Lupus Erythematosus ◽  
European American ◽  
Systemic Lupus ◽  
Autoantibody Profiles

scholarly journals Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women

Lupus ◽  
2018 ◽  
Vol 27 (13) ◽  
pp. 2129-2134 ◽  
Author(s):  
J N Williams ◽  
S-C Chang ◽  
C Sinnette ◽  
S Malspeis ◽  
C G Parks ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
African American Women ◽  
Lupus Erythematosus ◽  
Urban Population ◽  
Pesticide Exposure ◽  
Adult Women ◽  
Systemic Lupus ◽  
Community Screening ◽  
American Women

Objective: Past studies have reported associations between pesticide exposure and the risk of systemic lupus erythematosus (SLE). Residential pesticide exposure has been less well studied than agricultural exposure. The purpose of this study was to assess SLE risk associated with residential pesticide exposure in an urban population of predominantly African-American women. Methods: Adult women with SLE were identified from six hospital databases and community screening in three neighborhoods in Boston, Massachusetts, USA. Controls were adult women volunteers from the same neighborhoods who were screened for the absence of connective tissue disease and anti-nuclear antibodies. Subjects were considered exposed to pesticides if they had ever had an exterminator for an ant, cockroach, or termite problem prior to SLE diagnosis or corresponding reference age in controls. Risks associated with pesticide exposure were analyzed using multivariable logistic regression models, adjusted for sociodemographic factors. Results: We identified 93 SLE subjects and 170 controls with similar baseline characteristics. Eighty-three per cent were African-American. Pesticide exposure was associated with SLE, after controlling for potential confounders (odds ratio 2.24, 95% confidence interval 1.28–3.93). Conclusion: Residential exposure to pesticides in an urban population of predominantly African-American women was associated with increased SLE risk. Additional studies are needed to corroborate these findings.

Autoantibodies in Pediatric Systemic Lupus Erythematosus: Ethnic Grouping, Cluster Analysis, and Clinical Correlations

2009 ◽  
Vol 36 (2) ◽  
pp. 416-421 ◽  
Author(s):  
ROMAN JURENCÁK ◽  
MARVIN FRITZLER ◽  
PASCAL TYRRELL ◽  
LINDA HIRAKI ◽  
SUSANNE BENSELER ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cluster Analysis ◽  
Ethnic Groups ◽  
Ethnic Differences ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Pediatric Systemic Lupus Erythematosus ◽  
Mild Disease ◽  
Cluster 2 ◽  
Autoantibody Profiles

Objective.(1) To evaluate the spectrum of serum autoantibodies in pediatric-onset systemic lupus erythematosus (pSLE) with a focus on ethnic differences; (2) using cluster analysis, to identify patients with similar autoantibody patterns and to determine their clinical associations.Methods.A single-center cohort study of all patients with newly diagnosed pSLE seen over an 8-year period was performed. Ethnicity, clinical, and serological data were prospectively collected from 156/169 patients (92%). The frequencies of 10 selected autoantibodies among ethnic groups were compared. Cluster analysis identified groups of patients with similar autoantibody profiles. Associations of these groups with clinical and laboratory features of pSLE were examined.Results.Among our 5 ethnic groups, there were differences only in the prevalence of anti-U1RNP and anti-Sm antibodies, which occurred more frequently in non-Caucasian patients (p < 0.0001, p < 0.01, respectively). Cluster analysis revealed 3 autoantibody clusters. Cluster 1 consisted of anti-dsDNA antibodies. Cluster 2 consisted of anti-dsDNA, antichromatin, antiribosomal P, anti-U1RNP, anti-Sm, anti-Ro and anti-La autoantibody. Cluster 3 consisted of anti-dsDNA, anti-RNP, and anti-Sm autoantibody. The highest proportion of Caucasians was in cluster 1 (p < 0.05), which was characterized by a mild disease with infrequent major organ involvement compared to cluster 2, which had the highest frequency of nephritis, renal failure, serositis, and hemolytic anemia, or cluster 3, which was characterized by frequent neuropsychiatric disease and nephritis.Conclusion.We observed ethnic differences in autoantibody profiles in pSLE. Autoantibodies tended to cluster together and these clusters were associated with different clinical courses.

scholarly journals Validity of a Self-Administered Version of the Brief Index of Lupus Damage in a Predominantly African American Systemic Lupus Erythematosus Cohort

2014 ◽  
Vol 66 (6) ◽  
pp. 888-896 ◽  
Author(s):  
C. Drenkard ◽  
J. Yazdany ◽  
L. Trupin ◽  
P. P. Katz ◽  
C. Dunlop-Thomas ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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