scholarly journals Validity of a Self-Administered Version of the Brief Index of Lupus Damage in a Predominantly African American Systemic Lupus Erythematosus Cohort

2014 ◽  
Vol 66 (6) ◽  
pp. 888-896 ◽  
Author(s):  
C. Drenkard ◽  
J. Yazdany ◽  
L. Trupin ◽  
P. P. Katz ◽  
C. Dunlop-Thomas ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women

Lupus ◽  
2018 ◽  
Vol 27 (13) ◽  
pp. 2129-2134 ◽  
Author(s):  
J N Williams ◽  
S-C Chang ◽  
C Sinnette ◽  
S Malspeis ◽  
C G Parks ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
African American Women ◽  
Lupus Erythematosus ◽  
Urban Population ◽  
Pesticide Exposure ◽  
Adult Women ◽  
Systemic Lupus ◽  
Community Screening ◽  
American Women

Objective: Past studies have reported associations between pesticide exposure and the risk of systemic lupus erythematosus (SLE). Residential pesticide exposure has been less well studied than agricultural exposure. The purpose of this study was to assess SLE risk associated with residential pesticide exposure in an urban population of predominantly African-American women. Methods: Adult women with SLE were identified from six hospital databases and community screening in three neighborhoods in Boston, Massachusetts, USA. Controls were adult women volunteers from the same neighborhoods who were screened for the absence of connective tissue disease and anti-nuclear antibodies. Subjects were considered exposed to pesticides if they had ever had an exterminator for an ant, cockroach, or termite problem prior to SLE diagnosis or corresponding reference age in controls. Risks associated with pesticide exposure were analyzed using multivariable logistic regression models, adjusted for sociodemographic factors. Results: We identified 93 SLE subjects and 170 controls with similar baseline characteristics. Eighty-three per cent were African-American. Pesticide exposure was associated with SLE, after controlling for potential confounders (odds ratio 2.24, 95% confidence interval 1.28–3.93). Conclusion: Residential exposure to pesticides in an urban population of predominantly African-American women was associated with increased SLE risk. Additional studies are needed to corroborate these findings.

scholarly journals Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic lupus erythematosus patients

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182483 ◽  
Author(s):  
Ashira Blazer ◽  
Binhuan Wang ◽  
Danny Simpson ◽  
Tomas Kirchhoff ◽  
Sean Heffron ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African American ◽  
Lupus Erythematosus ◽  
Atherosclerotic Disease ◽  
Systemic Lupus ◽  
Risk Variants ◽  
Apolipoprotein L1

scholarly journals Risk of Renal Failure Within 10 or 20 Years of Systemic Lupus Erythematosus Diagnosis

2020 ◽  
pp. jrheum.191094
Author(s):  
Michelle Petri ◽  
Erik Barr ◽  
Laurence S. Magder
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Failure ◽  
African American ◽  
Lupus Erythematosus ◽  
Strong Predictor ◽  
Large Population ◽  
The United States ◽  
First Year ◽  
Systemic Lupus ◽  
American Ethnicity

Objective The frequency of endstage renal disease (ESRD) from systemic lupus erythematosus (SLE) in the United States has not improved over the last few decades in large population datasets. Understanding the risk factors for renal failure in SLE could lead to earlier detection of lupus nephritis and potentially more effective treatments in those with markers of poor prognosis. Methods The Hopkins Lupus Cohort, comprising 2528 patients was used. One hundred fifty-one patients experienced renal failure after SLE diagnosis, defined as dialysis or renal transplant. We estimated the risk of renal failure in subgroups defined by demographics, laboratory tests, and the American College of Rheumatology/Systemic Lupus International Collaborating Clinics (ACR/SLICC) classification criteria satisfied within 1 year of SLE diagnosis. Results The overall incidence of renal failure within 20 years of SLE diagnosis was 8.4%. The risk was much higher (20.0%) among those who experienced proteinuria within the first year of diagnosis. Demographic predictors included African American ethnicity [rate ratio (RR) 1.82, P = 0.0012] and age ≥ 40 years at SLE diagnosis (RR 0.51 vs those with diagnosis at < 30 yrs of age, P = 0.019). Among immunologic markers, low C3 was a strong predictor of renal failure (RR 2.00, P = 0.0011). Conclusion Proteinuria within the first year of diagnosis of SLE is one of the most important predictors of ESRD. Our data also confirm African American ethnicity, younger age at SLE diagnosis, and low C3 as strong predictors of renal failure.

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