scholarly journals 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases

2020 ◽  
Vol 72 (4) ◽  
pp. 461-488 ◽  
Author(s):  
Lisa R. Sammaritano ◽  
Bonnie L. Bermas ◽  
Eliza E. Chakravarty ◽  
Christina Chambers ◽  
Megan E. B. Clowse ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Musculoskeletal Diseases ◽  
American College Of Rheumatology

scholarly journals 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases

2020 ◽  
Vol 72 (4) ◽  
pp. 529-556 ◽  
Author(s):  
Lisa R. Sammaritano ◽  
Bonnie L. Bermas ◽  
Eliza E. Chakravarty ◽  
Christina Chambers ◽  
Megan E. B. Clowse ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Musculoskeletal Diseases ◽  
American College Of Rheumatology

SAT0105 INFLUENCE OF RITUXIMAB ON DIASTOLIC FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 986-986
Author(s):  
L. Feiskhanova ◽  
S. Lapshina ◽  
O. Rybakova
Keyword(s):  
Rheumatoid Arthritis ◽  
Diastolic Dysfunction ◽  
Qt Interval ◽  
Musculoskeletal Diseases ◽  
Antibody Therapy ◽  
Link Type ◽  
American College Of Rheumatology ◽  
Electrical Instability ◽  
And Function ◽  
The Impact

Background:One of the drugs used in the treatment of rheumatoid arthritis (RA) is rituximab. Given the fact that the RA affects not only the joints, but, in addition to other organs, and the heart, our interest has caused the likelihood of the impact of rituximab on non-articular manifestations of rheumatoid arthritis, in particular, related to the cardiovascular system.Objectives:to study the effect of rituximab on the development of diastolic dysfunction of the heart in patients with RA.Methods:98 patients with RA were examined, of which 28 patients took rituximab 1000 mg according to the scheme for 6-12 months and methotrexate up to 25 mg per week per os (1st group), and 70 patients – only methotrexate up to 25 mg per week at least 12 months (2nd group). They were held echocardiography with calculation of the E/a of mitral valve, E/a of tricuspid valve, end-diastolic size of left ventricle, electrocardiography with calculation of the dispersion of QT interval and vectorcardiography with determination of the areas of the P loop, QRS loop, T loop, and the maximum vector (MV), MV-azimuth and MV-lift.Results:the E/a of mitral and tricuspid valves in 1st group were higher than in 2nd group (p<0.05). In 1st group, a correlation was found between the E/a of both valves and the MV-lift; and also between the dispersion of QT interval and the maximum vector (p<0.05).Conclusion:in patients taking rituximab, there is a relationship between diastolic dysfunction, electrical instability of the ventricles and signs of electrophysiological remodeling. In addition, the use of rituximab is associated with a lower severity of diastolic dysfunction of both ventricles and a lower risk of life-threatening arrhythmias compared to the group that did not take this drug.References:[1]Singh J.A., Saag K.G., Shmerling R.H. et al. 2015 American College of Rheumatology Guidelinefor the Treatment of Rheumatoid Arthritis. Arthritis & Rheumatology 2016. Vol.68(1). P. 1–26. DOI:https://doi.org/10.1002/art.39480.[2]Davis J. M., Crowson C.S., Therneau T.M. et al. Five-Year Changes in Cardiac Structure and Function in Patients With Rheumatoid Arthritis Compared With the General Population // International journal of cardiology 2017. Vol. 240. P.379–385. DOI:https://doi.org/10.1016/j.ijcard.2017.03.108.[3]Rein P., Mueller, R.B. Treatment with Biologicals in Rheumatoid Arthritis: An Overview // Rheumatology and Therapy 2017. Vol.4(2). P.247-261. DOI:https://doi.org/10.1007/s40744-017-0073-3.[4]Smolen J.S, Goncalves J., Quinn M., et al. Era of biosimilars in rheumatology: reshaping the healthcare environment // Rheumatic & Musculoskeletal Diseases 2019.Vol.5(1). DOI:http://dx.doi.org/10.1136/rmdopen-2019-000900[5]Cohen M.D., Keystone E. Rituximab for Rheumatoid Arthritis // Rheumatology and Therapy 2015.Vol.2(2). P.99-111. DOI:https://doi.org/10.1007/s40744-015-0016-9[6]Pierpont T.M., Limper C.B., Richards K.L. Past, Present, and Future of Rituximab-The World’s First Oncology Monoclonal Antibody Therapy // Frontiers in Oncology 2018.Vol.4(163). DOI:https://doi.org/10.3389/fonc.2018.00163Disclosure of Interests:None declared

scholarly journals American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 2

2021 ◽  
Author(s):  
Jeffrey R. Curtis ◽  
Sindhu R. Johnson ◽  
Donald D. Anthony ◽  
Reuben J. Arasaratnam ◽  
Lindsey R. Baden ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
American College Of Rheumatology

scholarly journals POS0541 LOW PREVALENCE OF SSA (anti-Ro) AND SSB (anti-La) AUTOANTIBODIES IN FEMALE RHEUMATOID ARTHRITIS PATIENTS WITH A WISH TO CONCEIVE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 504.2-505
Author(s):  
H. T. Smeele ◽  
L. F. Perez-Garcia ◽  
J. M. J. Cornette ◽  
M. W. Schreurs ◽  
R. Dolhain
Keyword(s):  
Rheumatoid Arthritis ◽  
Lupus Erythematosus ◽  
Total Population ◽  
Musculoskeletal Diseases ◽  
Automated System ◽  
P Value ◽  
Neonatal Lupus ◽  
Female Patients ◽  
American College Of Rheumatology ◽  
Low Prevalence

Background:The presence of SSA (anti-Ro) and SSB (anti-La) autoantibodies has important clinical implications for female patients with a wish to conceive. The association between maternal levels of these autoantibodies and complete congenital heart block and neonatal Lupus syndrome is well established. Currently guidelines advise to test for these antibodies in all Rheumatoid Arthritis (RA) patients with a wish to conceive (1).Objectives:The objective was to determine the prevalence and titers of SSA and SSB autoantibodies in female patients with rheumatoid arthritis and a wish to conceive or who are pregnant.Methods:Patients were derived from 2 large prospective cohorts on RA and pregnancy (PARA-cohort and PreCARA-cohort). The presence and titers of SSA and SSB were tested using Phadia, an automated system which uses fluorescence enzyme immunoassays (FEIA) (Thermo-Fisher Scientific).Results:We included a total of 647 patients with RA and a wish to conceive, 417 (64.5%) conceived during the follow-up period. A detailed description of the study population, stratified for the presence of SSA and SSB antibodies autoantibodies is presented in table 1. A total of 25 out of 647 patients had detectable SSA or SSB antibodies: SSA n = 25 (SSA-52 n = 17, SSA-60 n = 19), SSB n = 7. This corresponds with a prevalence of 3.9% for SSA antibodies and 1.1% for SSB antibodies. 13 (52% of the SSA positive patients, 2.0% of the total population) patients had a titer of >240 units/ml of SSA antibodies, and 3 (42.9% of the SSB positive patients, 0.46% of the total population) patients had a titers >340 units/ml of SSB antibodies. The percentage of patients positive for RF antibodies was higher in SSA and/or SSB positive patients (p = 0.01).Table 1.Clinical and demographic features from 647 patients with rheumatoid arthritis and a wish to conceive.VariableSSA and SSB antibodies [-], n = 622Positive SSA and/or SSB antibodies [+], n = 25p-valueAge at inclusion in the cohort (y, SD)32.3 (4.0)32.3 (4.4)0.98Median disease duration at first visit, years (IQR)5.2 (2.2 – 9.8)4.9 (2.1 – 11.4)0.77ACPA positive, n (%)408/614 (66.5)16 (69.6)0.75Rheumatoid Factor positive, n (%)426/617 (69.0)23 (92.0)0.01Conclusion:Our study shows an overall low prevalence of SSA and SSB autoantibodies in female RA patients with a wish to conceive. Moreover, about half of the patients positive for SSA or SSB had, based on literature, moderate or low titers of these antibodies (2). Especially for RF negative patients, the current advise to test for SSA and SSB antibodies in all RA patients with a wish to conceive should be reconsidered.References:[1]Sammaritano LR et al. 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Arthritis Care Res (Hoboken). 2020 Apr; 72(4):461-488.[2]Jaeggi E et al. The Importance of the Level of Maternal Anti-Ro/SSA Antibodies as a Prognostic Marker of the Development of Cardiac Neonatal Lupus Erythematosus: A Prospective Study of 186 Antibody-Exposed Fetuses and Infants. Journal of the American College of Cardiology. 2010 2010/06/15/; 55(24):2778-2784Disclosure of Interests:Hieronymus TW Smeele: None declared, Luis Fernando Perez-Garcia Consultant of: Yes, Galapagos, J.M.J. Cornette: None declared, Marco WJ Schreurs: None declared, Radboud Dolhain Speakers bureau: Yes UCB, Roche, Abbvie, Genzyme, Novartis, Consultant of: Yes, Galapagos, Grant/research support from: Yes, UCB

scholarly journals DEFINITION OF THE TERM «RHEUMATOLOGY»: DO WE NEED THIS AND HOW DO THE EULAR AND THE ACR LOOK AT THIS?

2018 ◽  
Vol 56 (3) ◽  
pp. 389-390 ◽  
Author(s):  
Sh. F. Erdes
Keyword(s):  
Musculoskeletal Diseases ◽  
Healthcare Providers ◽  
Public Healthcare ◽  
Common Language ◽  
American College Of Rheumatology ◽  
European League Against Rheumatism ◽  
On Line ◽  
The One ◽  
Definition Of ◽  
Lay Public

The paper discusses the article «Common language description of the term rheumatic and musculoskeletal diseases (RMDs) for use in communication with the lay public, healthcare providers and other stakeholders endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)» that appeared in the on-line first journal Annals of the Rheumatic Diseases in March 2018. It is shown that, on the one hand, the development of the definition is positive, but, on the other, blurs the verges of rheumatology due to the introduction of nosological entities that are absolutely unrelated to our profession.

scholarly journals American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases – Version 1

2021 ◽  
Author(s):  
Jeffrey R Curtis ◽  
Sindhu R Johnson ◽  
Donald D Anthony ◽  
Reuben J. Arasaratnam ◽  
Lindsey R. Baden ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
American College Of Rheumatology

scholarly journals American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 3

2021 ◽  
Author(s):  
Jeffrey R. Curtis ◽  
Sindhu R. Johnson ◽  
Donald D. Anthony ◽  
Reuben J. Arasaratnam ◽  
Lindsey R. Baden ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
American College Of Rheumatology
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