scholarly journals Therapeutic analysis of Intrabeam‐based intraoperative radiation therapy in the treatment of unicentric breast cancer lesions utilizing a spherical target volume model

2017 ◽  
Vol 18 (5) ◽  
pp. 184-194 ◽  
Author(s):  
Madeline Schwid ◽  
Eric D. Donnelly ◽  
Hualin Zhang
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Target Volume ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation ◽  
Volume Model ◽  
Spherical Target

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

scholarly journals PD-0479: Intraoperative radiation therapy for breast cancer with INTRABEAMÆ: minimizing cost analysis

2015 ◽  
Vol 115 ◽  
pp. S236-S237
Author(s):  
B. Pinar ◽  
N. Rodriguez-Ibarria ◽  
M.A. Cabezon-Pons ◽  
D. Rey-Baltar ◽  
J.M. Blanco-Suarez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cost Analysis ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

scholarly journals Intraoperative radiation therapy for early stage breast cancer: experiences from Iran

2020 ◽  
Author(s):  
Vahid Zangouri ◽  
Hamid Nasrollahi ◽  
Ali Taheri ◽  
Majid Akrami ◽  
Peyman Arasteh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Patient Selection ◽  
Tumor Size ◽  
Ductal Carcinoma ◽  
Early Stage ◽  
Intraoperative Radiation Therapy ◽  
Study Patient ◽  
Intraoperative Radiation

Abstract Background and objective Currently no definite guideline exists on the use of intraoperative radiation therapy (IORT) among patients with early stage BC. We report our experiences with IORT among breast cancer (BC) patients in our region.Methods All patient who received radical IORT from April 2014 on to March 2020 were included in the study. Patient selection criteria were as followed: age equal or older than 45 years old; all cases of invasive carcinomas, moreover in lobular carcinomas only after MRI and confirmation, and in cases with ductal carcinoma in-situ (DCIS) only those with low, intermediate grade, tumor size of equal or less than 2.5cm and a margin of 2-3mm; those between 45 and 50 years old with a tumor size of 0-2cm, those between 50 and 55 years old with a tumor size of 2-2.5cm, and those ≥55 years old with a tumor size of 2.5-3cm; those with invasive tumors a negative margin and in cases of DCIS a margin of 3mm; a negative nodal status (exception in patients with micrometastasis); and a positive estrogen receptor status. Results Overall, 252 patients entered the study. Mean (SD) age of patients was 56.43±7.79 years. In total, 32.9% of patients had a family history of BC. Mean tumor size was 1.56±0.55 cm. Median (IQR) follow-up of patients was 24 (13, 36) months. Overall, 6 patients (2.4%) experienced recurrence in follow-up visits, among which three (1.2%) were local recurrence, two (0.8%) were regional recurrence and one patients (0.4%) had metastasis.Median (IQR) time to recurrence was 23 (13, 36) among the six patient who had recurrence. Overall, 11 patients (4.3%) with DCIS in our study received IORT. All these patients had free margins in histopathology examination. None of these patients experience recurrence.Conclusion For the first time, we categorized patients according to age and tumor size and older patients with larger tumor sizes were considered appropriate candidates for IORT. Our series showed a successful experience with the use of IORT in a region where facilities for IORT are limited using our modified criteria for patient selection.

Surgical and Oncologic Outcomes With Intraoperative Radiation Therapy for Early Breast Cancer

2021 ◽  
pp. 000313482110474
Author(s):  
Orli Friedman-Eldar ◽  
Christina Layton ◽  
Iago De Castro Silva ◽  
Mecker G Moller ◽  
Ahkeel Allen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Early Stage ◽  
Oncologic Outcomes ◽  
Intraoperative Radiation Therapy ◽  
Perioperative Outcomes ◽  
Wound Complications ◽  
Intraoperative Radiation ◽  
Areola Complex

Background For selected patients with early-stage breast cancer (BC), intraoperative radiation therapy (IORT) has emerged as a convenient alternative to standard whole breast irradiation (WBI). We report a single institution experience with IORT in terms of oncologic outcomes, toxicities, and cosmesis. Methods Clinicopathological and perioperative outcomes of patients who underwent IORT for early-stage BC at a public hospital from 2017 to 2020 were retrospectively retrieved. Toxicity was categorized to acute or chronic based on 6 months post-IORT cutoff. Results 85 patients underwent IORT and had complete data, aged 49‐85 years (mean 62). Intraoperative radiation therapy added 23 minutes on average to the total operative time. Final stage was 0, I, and II in 40%, 58.9%, and 1.1% of patients, respectively. Mean tumor size was 0.8 cm (range .1-2.1), with ductal histology comprising 94% of cases. Surgical margins were positive in 2 patients, and adjuvant WBI was required in 5 patients. After a median follow‐up of 17 months (range 3-41), none of the patients had local recurrence and no mortality was recorded. Early wound complications included wound dehiscence (n = 1), seroma/hematoma (n = 15), and re-operation with loss of nipple-areola complex (n = 1). Chronic skin toxicities were reported in 10 (12%) patients and good or excellent cosmetic outcome was reported in 93% of patients. Conclusions Utilizing IORT among low-risk early BC patients may be a safe and more convenient alternative to traditional WBI, with low toxicity rate, acceptable cosmetic results, and good oncologic outcomes at 17 months. Longer follow-up and further prospective controlled studies are needed to confirm these findings.

scholarly journals ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer

2020 ◽  
Vol 149 ◽  
pp. 150-157 ◽  
Author(s):  
Gerd Fastner ◽  
Christoph Gaisberger ◽  
Julia Kaiser ◽  
Philipp Scherer ◽  
Antonella Ciabattoni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Task Force ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

Intraoperative Radiation Therapy for Breast Cancer: Technical Notes

2003 ◽  
Vol 9 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Umberto Veronesi ◽  
Giovanna Gatti ◽  
Alberto Luini ◽  
Mattia Intra ◽  
Roberto Orecchia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

Surgical technique of intraoperative radiation therapy with electrons (ELIOT) in breast cancer: A lesson learned by over 1000 procedures

Surgery ◽  
2006 ◽  
Vol 140 (3) ◽  
pp. 467-471 ◽  
Author(s):  
Mattia Intra ◽  
Alberto Luini ◽  
Giovanna Gatti ◽  
Mario Ciocca ◽  
Oreste D. Gentilini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Surgical Technique ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
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