Therapeutic Gold Compounds

2014 ◽  
pp. 227-256 ◽  
Author(s):  
Susan J. Berners-Price ◽  
Peter J. Barnard
Keyword(s):  
Gold Compounds

Mössbauer Spectroscopy of Gold Compounds

1970 ◽  
Vol 53 (11) ◽  
pp. 4249-4264 ◽  
Author(s):  
Marjorie O. Faltens ◽  
D. A. Shirley
Keyword(s):  
Mössbauer Spectroscopy ◽  
Mossbauer Spectroscopy ◽  
Mößbauer Spectroscopy ◽  
Gold Compounds

scholarly journals Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 632
Author(s):  
Stephanie B. Wall ◽  
Rui Li ◽  
Brittany Butler ◽  
Ashley R. Burg ◽  
Hubert M. Tse ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Direct Interaction ◽  
Synthesis Methods ◽  
Related Factor ◽  
Gold Compound ◽  
Nuclear Factor ◽  
Glutathione Synthesis ◽  
Gold Compounds

Background: Alveolar macrophages (AMs) are resident inflammatory cells in the lung that serve as early sentinels of infection or injury. We have identified thioredoxin reductase 1 inhibition by gold compounds increases activation of nuclear factor erythroid 2-related factor 2 (NRF2)-dependent pathways to attenuate inflammatory responses. The present studies utilized murine alveolar macrophages (MH-S) to test the hypothesis that the gold compound, auranofin (AFN), decreases interleukin (IL)-1β expression through NRF2-mediated interactions with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway genes and/or increases in glutathione synthesis. Methods: MH-S cells were treated with AFN and lipopolysaccharide (LPS) and analyzed at 6 and 24 h. The Il1b promoter was analyzed by chromatin immunoprecipitation for direct interaction with NRF2. Results: Expression of IL-1β, p-IκBα, p-p65 NF-kB, and NOD-, LRR-, and pyrin domain-containing protein 3 were elevated by LPS exposure, but only IL-1β expression was suppressed by AFN treatment. Both AFN and LPS treatments increased cellular glutathione levels, but attenuation of glutathione synthesis by buthionine sulfoximine (BSO) did not alter expression of Il-1β. Analysis revealed direct NRF2 binding to the Il1b promoter which was enhanced by AFN and inhibited the transcriptional activity of DNA polymerase II. Conclusions: Our data demonstrate that AFN-induced NRF2 activation directly suppresses IL-1β synthesis independent of NFκB and glutathione-mediated antioxidant mechanisms. NRF2 binding to the promoter region of IL1β directly inhibits transcription of the IL1β gene. Collectively, our research suggests that gold compounds elicit NRF2-dependent pulmonary protection by suppressing macrophage-mediated inflammation.

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities

2014 ◽  
Vol 141 ◽  
pp. 79-82 ◽  
Author(s):  
Nicola Micale ◽  
Tanja Schirmeister ◽  
Roberta Ettari ◽  
Maria A. Cinellu ◽  
Laura Maiore ◽  
...  
Keyword(s):  
Significant Inhibition ◽  
20S Proteasome ◽  
Catalytic Activities ◽  
Gold Compounds

Low-dose gold compounds inhibit fibroblast proliferation and do not affect interleukin-1 secretion by macrophages

1988 ◽  
Vol 31 (10) ◽  
pp. 1272-1280 ◽  
Author(s):  
Tsukasa Matsubara ◽  
Yasuhiro Saegusa ◽  
Kazushi Hirohata
Keyword(s):  
Low Dose ◽  
Interleukin 1 ◽  
Fibroblast Proliferation ◽  
Gold Compounds
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