Functional Genomics Studies of Ovarian Function in Livestock: Physiological Insight Gained and Perspective for the Future

2010 ◽  
pp. 181-203
Author(s):  
Beau Schilling ◽  
George W. Smith
Keyword(s):  
Functional Genomics ◽  
Ovarian Function ◽  
The Future

Functional genomics, challenges and perspectives for the future

2013 ◽  
Vol 148 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Ron Mittler ◽  
Vladimir Shulaev
Keyword(s):  
Functional Genomics ◽  
The Future

scholarly journals BAC to the future: functional genomics in mammals

2008 ◽  
Vol 5 (5) ◽  
pp. 383-384 ◽  
Author(s):  
Assen Roguev ◽  
Nevan J Krogan
Keyword(s):  
Functional Genomics ◽  
The Future

Rice Genomics and the Future of Publicly Funded Rice Research

2002 ◽  
Vol 06 (24) ◽  
pp. 908-914
Author(s):  
Ronald P. Cantrell
Keyword(s):  
Private Sector ◽  
Functional Genomics ◽  
Working Group ◽  
Rice Genome ◽  
Rice Breeding ◽  
Financial Constraint ◽  
Publicly Funded ◽  
The Future

The article is about the sequencing of the rice genome, benefits of biotechnology, beyond rice breeding, financial constraint, the cooperation with private sector, public-privatization act, International Functional Genomics Working Group and the training of the scientists.

Proteomic Strategies and Their Application in Studies of Renal Function

Physiology ◽  
2004 ◽  
Vol 19 (3) ◽  
pp. 114-119 ◽  
Author(s):  
Pedro Cutillas ◽  
Alma Burlingame ◽  
Robert Unwin
Keyword(s):  
Mass Spectrometry ◽  
Renal Function ◽  
Liquid Chromatography ◽  
Functional Genomics ◽  
Gel Electrophoresis ◽  
Two Dimensional ◽  
Two Dimensional Gel Electrophoresis ◽  
The Future

Proteomics is a promising new tool for functional genomics. In addition to two-dimensional gel electrophoresis, other methods that are based on liquid chromatography and mass spectrometry are now available to study proteins. In this brief article, we review the strengths and limitations of the proteomic approaches currently available to the researcher, and we provide examples of how proteomics has been, and can in the future be, used to study the kidney.

scholarly journals Androgens and ovarian function: translation from basic discovery research to clinical impact

2019 ◽  
Vol 242 (2) ◽  
pp. R23-R50 ◽  
Author(s):  
K A Walters ◽  
V Rodriguez Paris ◽  
A Aflatounian ◽  
D J Handelsman
Keyword(s):  
Future Development ◽  
Molecular Mechanisms ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Poor Responders ◽  
Discovery Research ◽  
The Future ◽  
The Impact

In the last decade, it has been revealed that androgens play a direct and important role in regulating female reproductive function. Androgens mediate their actions via the androgen receptor (AR), and global and cell-specific Ar-knockout mouse models have confirmed that AR-mediated androgen actions play a role in regulating female fertility and follicle health, development and ovulation. This knowledge, along with the clinical data reporting a beneficial effect of androgens or androgen-modulating agents in augmenting in vitro fertilization (IVF) stimulation in women termed poor responders, has supported the adoption of this concept in many IVF clinics worldwide. On the other hand, substantial evidence from human and animal studies now supports the hypothesis that androgens in excess, acting via the AR, play a key role in the origins of polycystic ovary syndrome (PCOS). The identification of the target sites of these AR actions and the molecular mechanisms involved in underpinning the development of PCOS is essential to provide the knowledge required for the future development of novel, mechanism-based therapies for the treatment of PCOS. This review will summarize the basic scientific discoveries that have enhanced our knowledge of the roles of androgens in female reproductive function, discuss the impact these findings have had in the clinic and how a greater understanding of the role androgens play in female physiology may shape the future development of effective strategies to improve IVF outcomes in poor responders and the amelioration of symptoms in patients with PCOS.

An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming

2016 ◽  
pp. 45-72 ◽  
Author(s):  
Ole Kristian Tørresen ◽  
Matthew L. Rise ◽  
Xingkun Jin ◽  
Bastiaan Star ◽  
Simon MacKenzie ◽  
...  
Keyword(s):  
Functional Genomics ◽  
Atlantic Cod ◽  
The Future

scholarly journals The Mechanism of Androgen Actions in PCOS Etiology

2019 ◽  
Vol 7 (9) ◽  
pp. 89 ◽  
Author(s):  
Valentina Rodriguez Paris ◽  
Michael J. Bertoldo
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Future Development ◽  
Molecular Mechanisms ◽  
Ad Hoc ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
Female Fertility ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
The Future

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-age women. By comprising reproductive, endocrine, metabolic and psychological features—the cause of PCOS is still unknown. Consequently, there is no cure, and management is persistently suboptimal as it depends on the ad hoc management of symptoms only. Recently it has been revealed that androgens have an important role in regulating female fertility. Androgen actions are facilitated via the androgen receptor (AR) and transgenic Ar knockout mouse models have established that AR-mediated androgen actions have a part in regulating female fertility and ovarian function. Considerable evidence from human and animal studies currently reinforces the hypothesis that androgens in excess, working via the AR, play a key role in the origins of polycystic ovary syndrome (PCOS). Identifying and confirming the locations of AR-mediated actions and the molecular mechanisms involved in the development of PCOS is critical to provide the knowledge required for the future development of innovative, mechanism-based interventions for the treatment of PCOS. This review summarises fundamental scientific discoveries that have improved our knowledge of androgen actions in PCOS etiology and how this may form the future development of effective methods to reduce symptoms in patients with PCOS.

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