Approaches to Managing Protein Aggregation in Product Development

2010 ◽  
pp. 333-365 ◽  
Author(s):  
Wei Wang ◽  
Nicholas W. Warne
Keyword(s):  
Product Development ◽  
Protein Aggregation

An Ultra-Structural Study of Human Melanoma in Vivo and Vitro

1976 ◽  
Vol 34 ◽  
pp. 258-259
Author(s):  
James R. Gaylor ◽  
Fredda Schafer ◽  
Robert E. Nordquist
Keyword(s):  
Endoplasmic Reticulum ◽  
Golgi Apparatus ◽  
Protein Aggregation ◽  
Structural Study ◽  
Human Melanoma ◽  
Protein Matrix ◽  
Early Form ◽  
Endoplasmic Reticulum Protein ◽  
Mitochondrial Origin

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.

A novel P159L mutation in the Parkin gene related to autosomal dominantly inherited late onset parkinsonism and protein aggregation

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Krüger ◽  
FP Marx ◽  
D Berg ◽  
C Holzmann ◽  
T Müller ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Late Onset ◽  
Parkin Gene

USE OF RAPID PROTOTYPING IN PRODUCT DEVELOPMENT: A Case Study for Tool Manufacturing for Aeronautical Use

2017 ◽  
Vol 8 (5) ◽  
pp. 1-17
Author(s):  
Aires Jorge Alberto Sandi ◽  
◽  
Giacaglia Giorgio Eugenio Oscare ◽  
Keyword(s):  
Product Development ◽  
Rapid Prototyping

Experience Design Applied to Research

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Andrea CAPRA ◽  
Ana BERGER ◽  
Daniela SZABLUK ◽  
Manuela OLIVEIRA
Keyword(s):  
Information Technology ◽  
Product Development ◽  
Design Process ◽  
Development Process ◽  
Product Development Process ◽  
Experience Design ◽  
Low Resolution ◽  
Design Concepts ◽  
Innovative Products ◽  
Technological Products

An accurate understanding of users' needs is essential for the development of innovative products. This article presents an exploratory method of user centered research in the context of the design process of technological products, conceived from the demands of a large information technology company. The method is oriented - but not restricted - to the initial stages of the product development process, and uses low-resolution prototypes and simulations of interactions, allowing users to imagine themselves in a future context through fictitious environments and scenarios in the ambit of ideation. The method is effective in identifying the requirements of the experience related to the product’s usage and allows rapid iteration on existing assumptions and greater exploration of design concepts that emerge throughout the investigation.

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