Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery

2005 ◽  
pp. 289-313 ◽  
Author(s):  
Jim Wang ◽  
Jack Wang ◽  
Margaret Davis ◽  
William DeMaio ◽  
JoAnn Scatina ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Reactive Metabolites

Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72575-72585 ◽  
Author(s):  
Adnan A. Kadi ◽  
Hany W. Darwish ◽  
Mohamed W. Attwa ◽  
Sawsan M. Amer
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Reactive Metabolites ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Trapping Agent ◽  
Identification And Characterization

This study involved the identification and characterization of ponatinib by LC-MS/MS. Additionally ponatinib reactive metabolites were also investigated using KCN as a trapping agent, showing the formation of four reactive cyano adducts.

scholarly journals Correction: Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 10848-10848
Author(s):  
Adnan A. Kadi ◽  
Hany W. Darwish ◽  
Mohamed W. Attwa ◽  
Sawsan M. Amer
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Reactive Metabolites ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

Correction for ‘Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways’ by Adnan A. Kadi et al., RSC Adv., 2016, 6, 72575–72585.

Identification and characterization of in vitro, in vivo, and reactive metabolites of tandutinib using liquid chromatography ion trap mass spectrometry

2021 ◽  
Author(s):  
Nasser S. Al-Shakliah ◽  
Mohamed W. Attwa ◽  
Haitham AlRabiah ◽  
Adnan A. Kadi
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Trap ◽  
Reactive Metabolites ◽  
Ion Trap Mass Spectrometry ◽  
Identification And Characterization

Ten metabolites and five cyano adducts of TND were characterized using LC-ITMS. All metabolic and bioactivation reactions occurred at the N-piperidine and piperazine groups, which were predicted to be responsible for the TND toxicity and instability.

scholarly journals Characterization of Model Peptide Adducts with Reactive Metabolites of Naphthalene by Mass Spectrometry

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42053 ◽  
Author(s):  
Nathalie T. Pham ◽  
William T. Jewell ◽  
Dexter Morin ◽  
A. Daniel Jones ◽  
Alan R. Buckpitt
Keyword(s):  
Mass Spectrometry ◽  
Reactive Metabolites ◽  
Model Peptide ◽  
Peptide Adducts
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