Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

Zhengyin Yan; Noureddine Maher; Rhoda Torres; Gary W. Caldwell; Norman Huebert

doi:10.1002/rcm.2195

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2195 ◽

2005 ◽

Vol 19 (22) ◽

pp. 3322-3330 ◽

Cited By ~ 49

Author(s):

Zhengyin Yan ◽

Noureddine Maher ◽

Rhoda Torres ◽

Gary W. Caldwell ◽

Norman Huebert

Keyword(s):

Mass Spectrometry ◽

Stable Isotope ◽

Tandem Mass Spectrometry ◽

Rapid Detection ◽

Reactive Metabolites ◽

Tandem Mass

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Detection and characterization of glutathione conjugates using stable isotope labeling and tandem mass spectrometry

International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes ◽

10.1016/0883-2889(88)90224-9 ◽

1988 ◽

Vol 39 (6) ◽

pp. 521

Author(s):

Simon J. Gaskell ◽

Peter E. Haroldsen

Keyword(s):

Mass Spectrometry ◽

Stable Isotope ◽

Tandem Mass Spectrometry ◽

Isotope Labeling ◽

Stable Isotope Labeling ◽

Tandem Mass ◽

Glutathione Conjugates

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Characterization of metabolic profile of honokiol in rat feces using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and 13C stable isotope labeling

Journal of Chromatography B ◽

10.1016/j.jchromb.2014.01.047 ◽

2014 ◽

Vol 953-954 ◽

pp. 20-29 ◽

Cited By ~ 14

Author(s):

Yinfeng Dong ◽

Minghai Tang ◽

Hang Song ◽

Rong Li ◽

Chunyu Wang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Tandem Mass Spectrometry ◽

Metabolic Profile ◽

Isotope Labeling ◽

Time Of Flight ◽

Stable Isotope Labeling ◽

Tandem Mass

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Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽

10.1039/c6ra09985h ◽

2016 ◽

Vol 6 (76) ◽

pp. 72575-72585 ◽

Cited By ~ 22

Author(s):

Adnan A. Kadi ◽

Hany W. Darwish ◽

Mohamed W. Attwa ◽

Sawsan M. Amer

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Reactive Metabolites ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Trapping Agent ◽

Identification And Characterization

This study involved the identification and characterization of ponatinib by LC-MS/MS. Additionally ponatinib reactive metabolites were also investigated using KCN as a trapping agent, showing the formation of four reactive cyano adducts.

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Correction: Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways

RSC Advances ◽

10.1039/c7ra90020a ◽

2017 ◽

Vol 7 (18) ◽

pp. 10848-10848

Author(s):

Adnan A. Kadi ◽

Hany W. Darwish ◽

Mohamed W. Attwa ◽

Sawsan M. Amer

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Reactive Metabolites ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Correction for ‘Detection and characterization of ponatinib reactive metabolites by liquid chromatography tandem mass spectrometry and elucidation of bioactivation pathways’ by Adnan A. Kadi et al., RSC Adv., 2016, 6, 72575–72585.

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Molecular characterization of homo- and heterodimeric mercury(II)-bis-thiolates of some biologically relevant thiols by electrospray ionization and triple quadrupole tandem mass spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1016/s1044-0305(03)00768-2 ◽

2004 ◽

Author(s):

F Rubino

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Electrospray Ionization ◽

Molecular Characterization ◽

Tandem Mass ◽

Triple Quadrupole ◽

Biologically Relevant

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Structural Characterization of Cucurbitane Triterpenoids in Momordica charantia by Electrospray Ionization Tandem Mass Spectrometry

Planta Medica ◽

10.1055/s-2008-1075328 ◽

2008 ◽

Vol 74 (03) ◽

Author(s):

YH Wang ◽

B Avula ◽

Y Liu ◽

TJ Smillie ◽

IA Khan

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Electrospray Ionization ◽

Structural Characterization ◽

Momordica Charantia ◽

Tandem Mass ◽

Ionization Tandem Mass Spectrometry

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Direct infusion–tandem mass spectrometry combining with data mining strategies enables rapid chemome characterization of medicinal plants: A case study of Polygala tenuifolia

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2021.114281 ◽

2021 ◽

pp. 114281

Author(s):

Ting Li ◽

Zhizi Zhou ◽

Ke Zhang ◽

Wen Ma ◽

Wei Chen ◽

...

Keyword(s):

Mass Spectrometry ◽

Data Mining ◽

Medicinal Plants ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Direct Infusion ◽

Polygala Tenuifolia

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Synthesis and characterization of a series of N, N' ‐substituted urea derivatives by using electrospray ionization tandem mass spectrometry (ESI‐MS/MS): Differentiation of positional isomers

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.9161 ◽

2021 ◽

Author(s):

Dilip Kumar Singh ◽

Siddheshwar Kisan Chauthe ◽

Prakash Anjanappa ◽

Sumit Kumar ◽

Ruba A. Arulraj ◽

...

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Electrospray Ionization ◽

Synthesis And Characterization ◽

Tandem Mass ◽

Positional Isomers ◽

Urea Derivatives ◽

Esi Ms ◽

Ionization Tandem Mass Spectrometry

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Characterization of the multiple chemical components of Glechomae Herba using ultra high performance liquid chromatography coupled to quadrupole‐time‐of‐flight tandem mass spectrometry with diagnostic ion filtering strategy

Journal of Separation Science ◽

10.1002/jssc.201801212 ◽

2019 ◽

Vol 42 (7) ◽

pp. 1312-1322 ◽

Cited By ~ 4

Author(s):

Junmao Li ◽

Quan Wen ◽

Yulin Feng ◽

Jing Zhang ◽

Yun Luo ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

High Performance ◽

Chemical Components ◽

Tandem Mass ◽

Multiple Chemical ◽

Diagnostic Ion

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Detection of 1,N2-propano-2′-deoxyguanosine adducts in genomic DNA by ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry in combination with stable isotope dilution

Journal of Chromatography A ◽

10.1016/j.chroma.2016.04.067 ◽

2016 ◽

Vol 1450 ◽

pp. 38-44 ◽

Cited By ~ 9

Author(s):

Ning Zhang ◽

Yuanyuan Song ◽

Danni Wu ◽

Tian Xu ◽

Meiling Lu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Tandem Mass Spectrometry ◽

Isotope Dilution ◽

Genomic Dna ◽

Tandem Mass ◽

Stable Isotope Dilution ◽

Ultrahigh Performance Liquid Chromatography ◽

Ionization Tandem Mass Spectrometry

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