Analysis of Pharmaceutical Inactive Ingredients

2004 ◽  
pp. 85-94
Author(s):  
Xue-Ming Zhang
Keyword(s):  
Inactive Ingredients

scholarly journals Evolution of Internal Stress in Heterogeneous Electrode Composite during the Drying Process

Energies ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1683
Author(s):  
Zuoquan Zhu ◽  
Yaolong He ◽  
Hongjiu Hu ◽  
Fangzhou Zhang
Keyword(s):  
Internal Stress ◽  
Vinylidene Fluoride ◽  
Influence Factors ◽  
Lithium Ion ◽  
Integrated Analysis ◽  
Drying Time ◽  
Component Distribution ◽  
Poly Vinylidene Fluoride ◽  
Inactive Ingredients ◽  
Main Influence

The mechanical behavior of electrode composite during the drying preparation has played a crucial role in the electrochemical performance of lithium-ion batteries (LIBs). Our work aimed at developing an integrated analysis method to study the component distribution, mechanical properties, and internal stress of composite coating in the process of electrode drying. The main influence factors of drying stress were thoroughly investigated. It was found that this present model could capture not only the heterogeneity effect of inactive ingredients but also the porosity-dependent viscoelasticity of electrode composite. Meanwhile, the calculated effective modulus and stress evolution upon drying time were in acceptable accord with the experimental data. Furthermore, the rapid solidification markedly increased the drying stress in electrodes and significantly impaired the tensile strength of electrode composite due to the highly gradient distributed constituents. However, the stress level at high drying temperature could be significantly reduced by an aqueous sodium alginate binder instead of poly(vinylidene fluoride). The obtained results will be a great help in efficiently manufacturing LIB electrodes with adequate mechanical integrity.

Shedding light on interaction of so called inactive ingredients (excipients) with permeability-glycoprotein

2019 ◽  
Vol 52 ◽  
pp. 531-552
Author(s):  
Kiran Katrajkar ◽  
Lalit Darji ◽  
Devilal Kethavath ◽  
Shreya Thakkar ◽  
Bhavesh Kshirsagar ◽  
...  
Keyword(s):  
Inactive Ingredients

INACTIVE INGREDIENTS IN MEDICINES

The Lancet ◽  
1988 ◽  
Vol 332 (8604) ◽  
pp. 224
Author(s):  
V RIPPERE
Keyword(s):  
Inactive Ingredients

Japan: Database of inactive ingredients

The Lancet ◽  
1992 ◽  
Vol 339 (8799) ◽  
pp. 983
Author(s):  
Hirokuni Beppu
Keyword(s):  
Inactive Ingredients

scholarly journals Biologic excipients: Importance of clinical awareness of inactive ingredients

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0235076
Author(s):  
Yelena Ionova ◽  
Leslie Wilson
Keyword(s):  
Clinical Awareness ◽  
Inactive Ingredients

REVIEW ON - INGREDIENTS USED IN TOOTHPASTE FORMULATION

2020 ◽  
Vol 7 (9) ◽  
pp. 9-15
Keyword(s):  
Oral Health ◽  
Foaming Agents ◽  
Bacterial Films ◽  
Current Scenario ◽  
Sensitive Teeth ◽  
Inactive Ingredients ◽  
Oral Condition

Different ingredients are used in toothpaste formulation to keep the oral health and to achieve multi claim products. We have variety of toothpaste available in market like anti-cavity, extra-whitening and toothpaste for sensitive teeth, toothpastes with stripes, clear etc. At Current scenario, toothpaste contains different ingredients like abrasives which help to wash off bacterial films and fluorides to harden the teeth against caries and have thickeners that will give the ribbon stand up. The role of foaming agents is to remove the fatty films. The sweeteners play the role as a non-nutritive which may help stop the attraction of bacteria. Toothpaste contains both active and inactive ingredients which have their role and will be proposed in accordance to the oral condition of individuals.

"Inactive" Ingredients in Pharmaceutical Products

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 635-643 ◽  
Author(s):  
Keyword(s):  
Adverse Effects ◽  
Benzyl Alcohol ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Pharmaceutical Products ◽  
Controlled Study ◽  
Product Label ◽  
Metabolic Complications ◽  
Drug Products ◽  
Inactive Ingredients

Pharmaceuticals often contain agents that have a variety of purposes including improvement of the appearance, bioavailability, stability, and palatability of the product. Excipients frequently make up the majority of the mass or volume of oral and parenteral drug products. These pharmaceutical adjuvants are usually considered to be inert and do not add to or affect the intended action of the therapeutically active ingredient. Some 773 chemical agents have been approved by the Food and Drug Administration for use as inactive ingredients in drug products.1 Inasmuch as these compounds are classified as "inactive," manufacturers are not presently required to list them on the product label. These ingredients are used for a variety of different purposes (Table 1). Because of the large number of these agents and their frequency of use, practicing physicians have recently become concerned about their possible physiologic effects. The increasing number of reports of adverse effects associated with pharmaceutical excipients2 has led to professional and consumer organizations formally requesting the FDA (Food and Drug Administration) to require complete disclosure on the product label of all substances contained in pharmaceuticals. Problems encountered with "inactive" ingredients, include the following. ADVERSE EFFECTS OF PHARMACEUTICAL EXCIPIENTS Benzyl Alcohol This antimicrobial agent is commonly used as a preservative in many injectable drugs and solutions. A number of neonatal deaths and severe respiratory and metabolic complications in infants have been associated with use of this agent.3-5 In a controlled study, intraventricular hemorrhage, metabolic acidosis, and increased mortality were positively correlated with substantial benzoic acid and benzyl alcohol levels in neonates.6

The Ordering of Over-the-Counter Pharmaceutical Label Components

1996 ◽  
Vol 40 (3) ◽  
pp. 141-145 ◽  
Author(s):  
William J. Vigilante ◽  
Michael S. Wogalter
Keyword(s):  
Drug Interaction ◽  
Senior Citizens ◽  
Professional Organizations ◽  
Information Component ◽  
Over The Counter ◽  
Bar Code ◽  
Health Related ◽  
Locating Information ◽  
Inactive Ingredients ◽  
Flea Market

Recently there has been increasing interest in enabling consumers to more easily acquire information from over-the-counter (OTC) nonprescription pharmaceutical labels. Standardization of the format of labels is being considered by industry, government, and health-related professional organizations as a way to facilitate their usability. Potentially standardization could assist consumers in quickly locating information that they need to use the medication safely. The purpose of the present research is to determine whether consumers have a consistent preference for the ordering of information (component headings) on OTC drug labels. If so then this could serve as a partial basis for standardization. Results showed relatively consistent orders across four drugs and three participant groups (adults attending a flea market, senior citizens, and undergraduates). In general, the data indicate that people prefer that labels first provide what the drug is used for (indications); second provide information on associated hazards (warnings, cautions, drug interaction precautions) and use (directions); and third provide information on active ingredients. The remaining components were preferred in the following order: whether the package is safety sealed, inactive ingredients, storage instructions, manufacturer information, and then finally the bar code. Given the reasonable consistent orders generated by participants it seems plausible that if standardization were implemented that the ordering would roughly reflect this basic ordering.

Protective Effect of Inactive Ingredients against Nephrotoxicity of Vancomycin Hydrochloride in Rats

2004 ◽  
Vol 19 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Naoko Hodoshima ◽  
Yoshihisa Nakano ◽  
Masaaki Izumi ◽  
Nayu Mitomi ◽  
Yukari Nakamura ◽  
...  
Keyword(s):  
Protective Effect ◽  
Vancomycin Hydrochloride ◽  
Inactive Ingredients
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