Progress towards Identifying Inflammatory Bowel Disease Susceptibility Genes

2008 ◽  
pp. 3-16 ◽  
Author(s):  
John D. Rioux
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Susceptibility Genes ◽  
Inflammatory Bowel

Tu1792 - Allele-Specific DNA Methylation of Disease Susceptibility Genes in the Japanese Patients with Inflammatory Bowel Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-1020-S-1021
Author(s):  
Hirofumi Chiba ◽  
Yoichi Kakuta ◽  
Yoshitaka Kinouchi ◽  
Takeo Naito ◽  
Motoyuki Onodera ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Japanese Patients ◽  
Susceptibility Genes ◽  
Allele Specific ◽  
Inflammatory Bowel

scholarly journals Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194036 ◽  
Author(s):  
Hirofumi Chiba ◽  
Yoichi Kakuta ◽  
Yoshitaka Kinouchi ◽  
Yosuke Kawai ◽  
Kazuhiro Watanabe ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Japanese Patients ◽  
Susceptibility Genes ◽  
Allele Specific ◽  
Inflammatory Bowel

A transcript-based search for inflammatory bowel disease susceptibility genes on chromosome 16

2001 ◽  
Vol 120 (5) ◽  
pp. A458-A458
Author(s):  
A MOODY ◽  
S FISHER ◽  
M MIRZA ◽  
A CUTHBERT ◽  
J HAMPE ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Susceptibility Genes ◽  
Chromosome 16 ◽  
Inflammatory Bowel

scholarly journals Correction: Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0212148 ◽  
Author(s):  
Hirofumi Chiba ◽  
Yoichi Kakuta ◽  
Yoshitaka Kinouchi ◽  
Yosuke Kawai ◽  
Kazuhiro Watanabe ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Japanese Patients ◽  
Susceptibility Genes ◽  
Allele Specific ◽  
Inflammatory Bowel

A transcript-based search for inflammatory bowel disease susceptibility genes on chromosome 16

2001 ◽  
Vol 120 (5) ◽  
pp. A458
Author(s):  
Adrian Moody ◽  
Sheila Fisher ◽  
Muddassar M. Mirza ◽  
Andrew Cuthbert ◽  
Jochen Hampe ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Susceptibility Genes ◽  
Chromosome 16 ◽  
Inflammatory Bowel

scholarly journals Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice

2020 ◽  
Vol 21 (5) ◽  
pp. 311-325
Author(s):  
Karolyn G. Lahue ◽  
Montana K. Lara ◽  
Alisha A. Linton ◽  
Brigitte Lavoie ◽  
Qian Fang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Inflammatory Bowel

scholarly journals Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes

2021 ◽  
Author(s):  
Hongsheng Men ◽  
Miriam A. Hankins ◽  
Anagha S. Bock ◽  
Benjamin P. Beaton ◽  
Daniel J. Davis ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Alterations ◽  
Susceptibility Genes ◽  
Sprague Dawley ◽  
Knock Out ◽  
Rat Models ◽  
Inflammatory Bowel ◽  
Single Base Pair ◽  
Increased Susceptibility

AbstractMutations and single base pair polymorphisms in various genes have been associated with increased susceptibility to inflammatory bowel disease (IBD). We have created a series of rat strains carrying targeted genetic alterations within three IBD susceptibility genes: Nod2, Atg16l1, and Il23r, using CRISPR/Cas9 genome editing technology. Knock-out alleles and alleles with known human susceptibility polymorphisms were generated on three different genetic backgrounds: Fischer, Lewis and Sprague Dawley. The availability of these rat models will contribute to our understanding of the basic biological roles of these three genes as well as provide new potential IBD animal models.

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