Treatment of Refractory Chronic Pruritus of Unknown Origin With Tofacitinib in Patients With Rheumatoid Arthritis

2019 ◽  
Vol 155 (12) ◽  
pp. 1426 ◽  
Author(s):  
Fang Wang ◽  
Caroline Morris ◽  
Nancy D. Bodet ◽  
Brian S. Kim
Keyword(s):  
Rheumatoid Arthritis ◽  
Unknown Origin ◽  
Chronic Pruritus

scholarly journals Pathophysiology and Treatment of Pruritus in Elderly

2020 ◽  
Vol 22 (1) ◽  
pp. 174
Author(s):  
Bo Young Chung ◽  
Ji Young Um ◽  
Jin Cheol Kim ◽  
Seok Young Kang ◽  
Chun Wook Park ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Unknown Origin ◽  
The Elderly ◽  
Common Symptom ◽  
Multiple Factors ◽  
Signaling Mechanisms ◽  
Novel Drugs ◽  
Neuropathic Pruritus ◽  
Chronic Pruritus

Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments.

scholarly journals Rheumatoid arthritis, Pyrexia of Unknown Origin (PUO) and pancytopenia

Rheumatology ◽  
2006 ◽  
Vol 45 (4) ◽  
pp. 386-391
Author(s):  
K. Chakravarty ◽  
A. Kuttikat ◽  
I. Saeed ◽  
R. Thompson
Keyword(s):  
Rheumatoid Arthritis ◽  
Unknown Origin ◽  
Pyrexia Of Unknown Origin

scholarly journals Endothelial function and its role in the formation of cardiovascular pathology in patients with rheumatoid arthritis

2019 ◽  
Vol 100 (3) ◽  
pp. 451-456
Author(s):  
A A Tulichev ◽  
N Yu Borovkova ◽  
N N Borovkov ◽  
A A Spassky ◽  
I V Polyakova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Unknown Origin ◽  
Vascular Wall ◽  
Cardiovascular Complications ◽  
Point Of View ◽  
Microvascular Changes ◽  
Initial Stage

Currently rheumatoid arthritis is considered as an immune inflammatory disease of unknown origin characterized by chronic erosive arthritis and systemic damage of internal organs, leading to early disability and reduced life expectancy. Cardiovascular diseases are most often mentioned as factors of poor prognosis in rheumatoid arthritis. Pathology of the cardiovascular system in rheumatoid arthritis is usually associated with the macro- and microvascular changes and rheumatoid lesions of the heart. The leading factor in the damage of the vascular wall in rheumatoid arthritis is systemic inflammation affecting its viscosity and elastic properties, increased rigidity, impaired endothelial function. Endothelial dysfunction is currently regarded to as an initial stage of morphogenesis of various vascular disorders. It is considered as a subclinical marker of cardiovascular diseases and the earliest predictor of cardiovascular complications. From this point of view study of endothelial dysfunction in patients with rheumatoid arthritis aimed at determining cardiovascular risk is a perspective direction. Only single and fragmentary information about certain endothelial functions in patients with rheumatoid arthritis and substances released in this. There is no clear analysis of relationship between them and dependence on the process activity. Not clear is their role in the pathology of the vascular wall in rheumatoid arthritis. This literature review discusses the problem of endothelial dysfunction in rheumatoid arthritis patients as well as its role in the development of cardiovascular diseases in these patients. The development mechanisms and the role of immune inflammation in its formation are considered. Also the association was found between chronic inflammatory activity indicators in rheumatoid arthritis and various biological markers and development of endothelial dysfunction. The effects of antirheumatic treatment on endothelial dysfunction in these patients were analyzed.

scholarly journals Treatment of patients with chronic pruritus of unknown origin with dupilumab

2021 ◽  
pp. 1-4
Author(s):  
Jiehyun Jeon ◽  
Fang Wang ◽  
Asima Badic ◽  
Brian S. Kim
Keyword(s):  
Unknown Origin ◽  
Chronic Pruritus

scholarly journals Lactase Deficiency: A Potential Novel Aetiological Factor in Chronic Pruritus of Unknown Origin

2011 ◽  
Vol 91 (6) ◽  
pp. 698-703 ◽  
Author(s):  
S Grundmann ◽  
E Stratmann ◽  
R Brehler ◽  
T Luger ◽  
S Ständer
Keyword(s):  
Unknown Origin ◽  
Aetiological Factor ◽  
Lactase Deficiency ◽  
Chronic Pruritus
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