Peripheral airway obstruction and particulate deposition in the lung

1973 ◽  
Vol 131 (1) ◽  
pp. 93-97 ◽  
Author(s):  
P. T. Macklem
Keyword(s):  
Airway Obstruction ◽  
Particulate Deposition ◽  
Peripheral Airway

Computer-aided classification of small airways dysfunction using impulse oscillometric features: a children-focused review

2020 ◽  
Vol 65 (2) ◽  
pp. 121-131
Author(s):  
Nancy Avila ◽  
Homer Nazeran ◽  
Nelly Gordillo ◽  
Erika Meraz ◽  
Laura Gochicoa
Keyword(s):  
Pulmonary Function ◽  
Airway Obstruction ◽  
Small Airways ◽  
Asthma Diagnosis ◽  
Great Opportunity ◽  
Asthmatic Children ◽  
Computer Aided ◽  
Peripheral Airway ◽  
And Control

AbstractBackground and objectiveSpirometry, which is the most commonly used technique for asthma diagnosis, is often unsuitable for small children as it requires them to follow exact instructions and perform extreme inspiration and expiration maneuvers. In contrast, impulse oscillometry (IOS) is a child-friendly technique that could serve as an alternative pulmonary function test (PFT) for asthma diagnosis and control in children as it offers several advantages over spirometry. However, the complex test results of IOS may be difficult to be understood by practitioners due to its reliance on mechanical and electrical models of the human pulmonary system. Recognizing this reality, computer-aided decision systems could help to improve the utility of IOS. The main objective of this paper is to understand the current computer-aided classification research works on this topic.MethodsThis paper presents a methodological review of research works related to the computer-aided classification of peripheral airway obstruction using the IOS technique, which is focused on, but not limited to, asthmatic children. Publications that focused on computer-aided classification of asthma, peripheral dysfunction and/or small airway impairment (SAI) based on impulse oscillometric features were selected for this review.ResultsOut of the 34 articles that were identified using the selected scientific web databases and topic-related parameters, only eight met the eligibility criteria. The most relevant results of the articles reviewed are related to the performance of the different classifiers using static features which are solely based on the first pulmonary function testing measurements (IOS and spirometry). These results included an overall classifiers’ accuracy performance ranging from 42.24% to 98.61%.ConclusionThere is still a great opportunity to improve the utility of IOS by developing more computer-aided robust classifiers, specifically for the asthmatic children population as the classification studies performed to date (1) are limited in number, (2) include features derived from tests that are not optimally suitable for children, (3) are solely bi-class (mostly asthma and non-asthma) and therefore fail to include different degrees of peripheral obstruction for disease prevention and control and (4) lack of validation in cases that focus on multi-class classification of the different degrees of peripheral airway obstruction.

Effect of clenbuterol on peripheral airway obstruction in bronchial asthma

1985 ◽  
Vol 9 (9) ◽  
pp. 616-625 ◽  
Author(s):  
W. Hida ◽  
M. Sakurai ◽  
M. Ichinose ◽  
C. Shindoh ◽  
T. Chonan ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Bronchial Asthma ◽  
Peripheral Airway

Peripheral Airway Obstruction

JAMA ◽  
1976 ◽  
Vol 235 (3) ◽  
pp. 259 ◽  
Author(s):  
E. R. McFadden
Keyword(s):  
Airway Obstruction ◽  
Peripheral Airway

COPD patients with peripheral airway obstruction reversibility identified by exhaled nitric oxide

2019 ◽  
Vol 13 (3) ◽  
pp. 036002 ◽  
Author(s):  
Silvia Pérez-Bogerd ◽  
Alain Michils ◽  
Andrei Malinovschi ◽  
Alain Van Muylem
Keyword(s):  
Nitric Oxide ◽  
Airway Obstruction ◽  
Exhaled Nitric Oxide ◽  
Copd Patients ◽  
Peripheral Airway

scholarly journals Evaluating bronchodilator response in pediatric patients with post-infectious bronchiolitis obliterans: use of different criteria for identifying airway reversibility

2016 ◽  
Vol 42 (3) ◽  
pp. 174-178 ◽  
Author(s):  
Rita Mattiello ◽  
Paula Cristina Vidal ◽  
Edgar Enrique Sarria ◽  
Paulo Márcio Pitrez ◽  
Renato Tetelbom Stein ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Bronchiolitis Obliterans ◽  
Pediatric Patients ◽  
Bronchodilator Response ◽  
Peripheral Airway ◽  
Pediatric Pulmonology ◽  
History Of ◽  
Asthma And Allergy ◽  
The Mean ◽  
Post Infectious

ABSTRACT Objective: Post-infectious bronchiolitis obliterans (PIBO) is a clinical entity that has been classified as constrictive, fixed obstruction of the lumen by fibrotic tissue. However, recent studies using impulse oscillometry have reported bronchodilator responses in PIBO patients. The objective of this study was to evaluate bronchodilator responses in pediatric PIBO patients, comparing different criteria to define the response. Methods: We evaluated pediatric patients diagnosed with PIBO and treated at one of two pediatric pulmonology outpatient clinics in the city of Porto Alegre, Brazil. Spirometric parameters were measured in accordance with international recommendations. Results: We included a total of 72 pediatric PIBO patients. The mean pre- and post-bronchodilator values were clearly lower than the reference values for all parameters, especially FEF25-75%. There were post-bronchodilator improvements. When measured as mean percent increases, FEV1 and FEF25-75%, improved by 11% and 20%, respectively. However, when the absolute values were calculated, the mean FEV1 and FEF25-75% both increased by only 0.1 L. We found that age at viral aggression, a family history of asthma, and allergy had no significant effects on bronchodilator responses. Conclusions: Pediatric patients with PIBO have peripheral airway obstruction that is responsive to treatment but is not completely reversible with a bronchodilator. The concept of PIBO as fixed, irreversible obstruction does not seem to apply to this population. Our data suggest that airway obstruction is variable in PIBO patients, a finding that could have major clinical implications.

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