Superficial mycoses: treatment with a new, broad-spectrum antifungal agent: 1% clotrimazole solution

1977 ◽  
Vol 113 (3) ◽  
pp. 307-308 ◽  
Author(s):  
N. Zaias
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Superficial Mycoses

Highly stereoselective access to novel 2,2,4-substituted tetrahydrofurans by halocyclization: Practical chemoenzymatic synthesis of Sch 51048, a broad-spectrum orally active antifungal agent

1995 ◽  
Vol 36 (11) ◽  
pp. 1787-1790 ◽  
Author(s):  
Anil K Saksena ◽  
Viyyoor M Girijavallabhan ◽  
Raymond G Lovey ◽  
Russell E Pike ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Chemoenzymatic Synthesis ◽  
Orally Active

scholarly journals Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent

2015 ◽  
Vol 61 (10) ◽  
pp. 1558-1565 ◽  
Author(s):  
Marisa H. Miceli ◽  
Carol A. Kauffman
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent

The Rise and Fall of Oral Ketoconazole

2015 ◽  
Vol 19 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Aditya K. Gupta ◽  
Danika C.A. Lyons
Keyword(s):  
United States ◽  
Side Effects ◽  
Broad Spectrum ◽  
The United States ◽  
Line Treatment ◽  
First Line ◽  
Superficial Mycoses ◽  
Tinea Versicolor ◽  
Endemic Mycoses ◽  
First Line Treatment

Background: Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its approval. Growing evidence of serious side effects including endocrine dysregulation, several drug interactions, and death led to the review of oral ketoconazole in 2011. Objective: This article chronicles the use of oral ketoconazole from its introduction to its near replacement in medicine. Conclusion: Due to its hepatotoxic side effects, oral ketoconazole was withdrawn from the European and Australian markets in 2013. The United States imposed strict relabeling requirements and restrictions for prescription, with Canada issuing a risk communication echoing these concerns. Today, oral ketoconazole is only indicated for endemic mycoses, where alternatives are not available or feasible. Meanwhile, topical ketoconazole is effective, safe, and widely prescribed for superficial mycoses, particularly as the first-line treatment for tinea versicolor.

Tioconazole, a New Broad-Spectrum Antifungal Agent: Preclinical Studies Related to Vaginal Candidiasis

1983 ◽  
Vol 23 (1) ◽  
pp. 1-11
Author(s):  
M.S. Marriott ◽  
K.W. Brammer ◽  
J. Faccini ◽  
J.K. Faulkner ◽  
S. Jevons ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Vaginal Candidiasis ◽  
Preclinical Studies

scholarly journals Posaconazole: A Broad-Spectrum Triazole Antifungal Agent

2007 ◽  
Vol 45 (12) ◽  
pp. 1610-1617 ◽  
Author(s):  
V. Nagappan ◽  
S. Deresinski
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent
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