scholarly journals ENHANCED FIELD OBSERVATION BASED PHYSICAL AND NUMERICAL MODELLING OF TSUNAMI INDUCED BOULDER TRANSPORT PHASE 1: PHYSICAL EXPERIMENTS

2017 ◽  
pp. 4 ◽  
Author(s):  
Jan Oetjen ◽  
Max Engel ◽  
Helmut Brückner ◽  
Shiva P. Pudasaini ◽  
Holger Schüttrumpf
Keyword(s):  
Numerical Modelling ◽  
Laboratory Experiments ◽  
Transport Model ◽  
Phase 1 ◽  
Storm Surges ◽  
High Energy ◽  
Real World Data ◽  
Two Phase ◽  
Physical Experiments ◽  
Physical Laboratory

Coasts around the world are affected by high-energy wave events like storm surges or tsunamis. By focusing on tsunami impacts, we investigate tsunami-induced transport of boulders by an interdisciplinary combination of field observations, laboratory experiments and advanced numerical modelling. In phase 1 of the project we conduct physical laboratory experiments based on real-world data. Following the experimental phase we will develop an enhanced numerical boulder transport model (BTM) based on an existing two-phase model.

Transport of organochlorine pesticides in soil columns enhanced by dissolved organic carbon

1997 ◽  
Vol 35 (7) ◽  
pp. 139-145 ◽  
Author(s):  
Jiann-Yuan Ding ◽  
Shian-Chee Wu
Keyword(s):  
Organic Carbon ◽  
Dissolved Organic Carbon ◽  
Organochlorine Pesticides ◽  
Transport Model ◽  
Phase Model ◽  
Soil Columns ◽  
Two Phase ◽  
Three Phase ◽  
Phase Transport ◽  
Remediation Of Soil

The objective of this study is to quantify the effects of humic acid solution infiltration on the transport of organochlorine pesticides (OCPs) in soil columns using a three-phase transport model. From experimental results, it is found that the dissolved organic carbon enhances the transport of OCPs in the soil columns. In the OCPs-only column, the concentration profiles of OCPs can be simulated well using a two-phase transport model with numerical method or analytical solution. In the OCPs-DOC column, the migrations of aldrin, DDT and its daughter compounds are faster than those in the OCPs-only column. The simulation with the three-phase model is more accurate than that with the two-phase model. In addition, significant decrease of the fluid pore velocities of the OCPs-DOC column was found. When DOC leachate is applied for remediation of soil or groundwater pollution, the decrease of mean pore velocities will be a crucial affecting factor.

scholarly journals Settling Velocity of Microplastics Exposed to Wave Action

2021 ◽  
Vol 9 (2) ◽  
pp. 142
Author(s):  
Annalisa De Leo ◽  
Laura Cutroneo ◽  
Damien Sous ◽  
Alessandro Stocchino
Keyword(s):  
Laboratory Experiments ◽  
Settling Velocity ◽  
Transport Model ◽  
Stokes Drift ◽  
Inertial Effects ◽  
Sea Waves ◽  
Heavy Particles ◽  
Analytical Formulation ◽  
Simplified Approach ◽  
Remote Areas

Microplastic (MP) debris is recognized to be one of the most serious threats to marine environments. They are found in all seas and oceanic basins worldwide, even in the most remote areas. This is further proof that the transport of MPs is very efficient. In the present study, we focus our attention on MPs’ transport owing to the Stokes drift generated by sea waves. Recent studies have shown that the interaction between heavy particles and Stokes drift leads to unexpected phenomena mostly related to inertial effects. We perform a series of laboratory experiments with the aim to directly measure MPs’ trajectories under different wave conditions. The main objective is to quantify the inertial effect and, ultimately, suggest a new analytical formulation for the net settling velocity. The latter formula might be implemented in a larger scale transport model in order to account for inertial effects in a simplified approach.

Endometrial Adenocarcinoma in SurePath™ Cervical Samples: Cytological Features Revisited

2016 ◽  
Vol 60 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Nalini Gupta ◽  
John Crossley ◽  
Nick Dudding ◽  
John H.F. Smith
Keyword(s):  
Phase 1 ◽  
Endometrial Adenocarcinoma ◽  
Nuclear Chromatin ◽  
Phase 2 ◽  
Cervical Lesions ◽  
Two Phase ◽  
Endometrial Cells ◽  
Phase Study ◽  
Cytological Features ◽  
Liquid Based Cytology

Objective: The cytomorphological criteria of malignant endometrial lesions in cervical samples are less well described than those of cervical lesions. We wished to investigate if there were features in SurePath™ liquid-based cytology samples that would facilitate more accurate differentiation between benign and malignant endometrial cells. Study Design: This was a two-phase study, with a review of all SurePath™ samples reported as endometrial adenocarcinoma (n = 42) evaluating 12 cytological features in the first phase. In phase 2 (test set), all initial cases plus an additional 83 cases were reviewed using these 12 cytological features to predict the outcome. Results: Out of 12 cytological features evaluated in phase 1 (training set), nuclear chromatin pattern, apoptotic bodies and tingible body macrophages were found to be the most significant features determining malignant histological outcome. These 12 cytological features were re-evaluated in phase 2 (n = 125). Of 125 cases, 54 had a benign and 71 had a malignant or premalignant histological outcome, with a positive predictive value of 56.8%. Conclusion: Granular nuclear chromatin, tingible body macrophages and apoptosis in the background are the most significant factors in determining whether endometrial cells present in cervical samples represent malignancy or are benign. Using these features, relatively accurate predictions of endometrial pathology can be made.

166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: results of two phase 1/2 trials

Blood ◽  
2003 ◽  
Vol 102 (7) ◽  
pp. 2684-2691 ◽  
Author(s):  
Sergio Giralt ◽  
William Bensinger ◽  
Mark Goodman ◽  
Donald Podoloff ◽  
Janet Eary ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Phase 1 ◽  
High Dose ◽  
Two Phase ◽  
Hematopoietic Stem

Abstract Holmium-166 1, 4, 7, 10-tetraazcyclododecane-1, 4, 7, 10-tetramethylenephosphonate (166Ho-DOTMP) is a radiotherapeutic that localizes specifically to the skeleton and can deliver high-dose radiation to the bone and bone marrow. In patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation two phase 1/2 dose-escalation studies of high-dose 166Ho-DOTMP plus melphalan were conducted. Patients received a 30 mCi (1.110 Gbq) tracer dose of 166Ho-DOTMP to assess skeletal uptake and to calculate a patient-specific therapeutic dose to deliver a nominal radiation dose of 20, 30, or 40 Gy to the bone marrow. A total of 83 patients received a therapeutic dose of 166Ho-DOTMP followed by autologous hematopoietic stem cell transplantation 6 to 10 days later. Of the patients, 81 had rapid and sustained hematologic recovery, and 2 died from infection before day 60. No grades 3 to 4 nonhematologic toxicities were reported within the first 60 days. There were 27 patients who experienced grades 2 to 3 hemorrhagic cystitis, only 1 of whom had received continuous bladder irrigation. There were 7 patients who experienced complications considered to be caused by severe thrombotic microangiopathy (TMA). No cases of severe TMA were reported in patients receiving in 166Ho-DOMTP doses lower than 30 Gy. Approximately 30% of patients experienced grades 2 to 4 renal toxicity, usually at doses targeting more than 40 Gy to the bone marrow. Complete remission was achieved in 29 (35%) of evaluable patients. With a minimum follow-up of 23 months, the median survival had not been reached and the median event-free survival was 22 months. 166Ho-DOTMP is a promising therapy for patients with multiple myeloma and merits further evaluation. (Blood. 2003;102:2684-2691)

A Framework for Implementing Lean Manufacturing System in Small and Medium Enterprises

2011 ◽  
Vol 110-116 ◽  
pp. 3997-4003 ◽  
Author(s):  
Jirapat Wanitwattanakosol ◽  
Apichat Sopadang
Keyword(s):  
Lean Manufacturing ◽  
Manufacturing System ◽  
Job Shop ◽  
Small And Medium Enterprises ◽  
Phase 1 ◽  
Optimization Technique ◽  
Value Stream Mapping ◽  
Two Phase ◽  
Make To Order ◽  
Medium Enterprises

—In this paper, a conceptual framework to apply many techniques for implementing lean in the high-variety low-volume (HVLV) environment is presented. Lean production has increasingly being implemented as a potential solution for many organizations. Anyway, the lean formula is applicable directly only to the make-to-stock business, but the make-to-order (MTO) product environment has to adapt lean manufacturing principle. The method of this paper has a two-phase quantitative framework to transform small and medium enterprises (SMEs) to be lean. Phase 1 has three interrelated components: (1) re-engineering an organization by using the power of computer simulation combined with business process. (2) Value stream mapping (VSM) is used to create a map of both value and waste in a given process. This tool has also a main drawback for job shop facility because many value streams are composed of hundreds of industrial parts and products. (3) Integrative supplier relationship is one of the most critical factors to maintain an advantage in the increasing levels of competition. Phase 2 performs a just in time production schedule by using ant colony optimization technique combines with a simulation tool. The aims of this paper are to develop a suitable lean manufacturing system for SMEs and to study the performance of the system for improving effectiveness. The result shows how to combine lean concept with simulation optimization, the step of this framework to obtain the optimization solution.

Preliminary results of numerical simulation of submarine landslide-generated waves

2021 ◽  
Author(s):  
Ramtin Sabeti ◽  
Mohammad Heidarzadeh
Keyword(s):  
Numerical Simulation ◽  
Numerical Modelling ◽  
Numerical Solutions ◽  
Numerical Technique ◽  
Source Region ◽  
Three Dimensional ◽  
Terminal Velocity ◽  
Sensitivity Analyses ◽  
Physical Experiments ◽  
Set Up

<p>Landslide-generated waves have been major threats to coastal areas and have led to destruction and casualties. Their importance is undisputed, most recently demonstrated by the 2018 Anak Krakatau tsunami, causing several hundred fatalities. The accurate prediction of the maximum initial amplitude of landslide waves (<em>η<sub>max</sub></em>) around the source region is a vital hazard indicator for coastal impact assessment. Laboratory experiments, analytical solutions and numerical modelling are three major methods to investigate the (<em>η<sub>max</sub></em>). However, the numerical modelling approach provides a more flexible and cost- and time-efficient tool. This research presents a numerical simulation of tsunamis due to rigid landslides with consideration of submerged conditions. In particular, this simulation focuses on studying the effect of landslide parameters on <em>η<sub>max</sub>.</em> Results of simulations are compared with our conducted physical experiments at the Brunel University London (UK) to validate the numerical model.</p><p>We employ the fully three-dimensional computational fluid dynamics package, FLOW-3D Hydro for modelling the landslide-generated waves. This software benefit from the Volume of Fluid Method (VOF) as the numerical technique for tracking and locating the free surface. The geometry of the simulation is set up according to the wave tank of physical experiments (i.e. 0.26 m wide, 0.50 m deep and 4.0 m). In order to calibrate the simulation model based on the laboratory measurements, the friction coefficient between solid block and incline is changed to 0.41; likewise, the terminal velocity of the landslide is set to 0.87 m/s. Good agreement between the numerical solutions and the experimental results is found. Sensitivity analyses of landslide parameters (e.g. slide volume, water depth, etc.) on <em>η<sub>max </sub></em>are performed. Dimensionless parameters are employed to study the sensitivity of the initial landslide waves to various landslide parameters.</p>

Safety and unique pharmacokinetic profile of ARX788, a site-specific ADC, in heavily pretreated patients with HER2-overexpresing solid tumors: Results from two phase 1 clinical trials.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 1038-1038
Author(s):  
Sara A. Hurvitz ◽  
Haeseong Park ◽  
Sophia Frentzas ◽  
Catherine M. Shannon ◽  
Katharine Cuff ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Phase 1 ◽  
Salivary Gland Cancer ◽  
Breast Cancers ◽  
Her2 Positive ◽  
Two Phase ◽  
Site Specific ◽  
Heavily Pretreated ◽  
Pretreated Patients ◽  
A Site

1038 Background: ARX788 is a site-specific, homogeneous, and highly stable ADC. The payload AS269 is conjugated to the synthetic amino acids para-acetylphenylalanine (pAF) in a humanized anti-HER2 mAb. ARX788 demonstrated promising activity in HER2-positive, HER2-low, and T-DM1 resistant tumors in preclinical studies. Here we present the phase 1 clinical data evaluating the safety, antitumor activity, and PK of ARX788 in advanced solid tumors. Methods: The standard 3+3 design (0.33 - 1.5 mg/kg; Q3W or Q4W) is used to determine the MTD and/or RP2D in two phase 1 studies in HER2-positive solid tumors in U.S. and Australia (ACE-Pan tumor-01) and in HER2-positive breast cancers in China (ACE-Breast-01). The efficacy endpoints include ORR and DCR. Intensive PK sampling in first 3 cycles is performed to characterize serum PK profiles of ARX788, total Ab, and pAF-AS269. Results: 69 and 34 heavily pretreated patients received ARX788 monotherapy in the ACE-Breast-01 (median 6 prior lines of therapy) and ACE-Pan tumor-01 trial (including breast, gastric/GEJ, NSCLC, ovarian, urothelial, biliary track, endometrial, and salivary gland cancer) respectively. Dose escalation for both studies have been completed with no DLT reported. MTD has not been reached. ARX788 was generally well tolerated with most AEs being grade 1 or 2. The most common grade >3 AEs include ocular AEs (5.7 %) and pneumonitis (4.3%) in the ACE-Breast-01 trial; pneumonitis (2.9%) and fatigue (2.9%) in the ACE-Pan tumor-01 trial. Low systemic toxicities in terms of the incidence rate and grade (as shown in table). No treatment-related death. In the 1.5 mg/kg cohort, ORR was 74% (14/19) and 67% (2/3) for ACE-Breast-01 and ACE-Pan tumor-01, respectively. DCR was 100%. Median DOR or median PFS has not been reached. PK profiles for total antibody and ARX788 were generally comparable across all dose levels. Mean T1/2 for ARX788 and total antibody had approximately 100 hours at the dose of 1.5 mg/kg. Serum pAF-AS269 concentrations peaked with a median time of 168 h. Serum exposure of pAF-AS269 was low with the Cmax and AUC at cycle 1 being approximately 0.1% and 0.18% of those for ARX788 on a molar basis, respectively. Conclusions: High stability of ARX788 and low serum exposure of pAF-AS269 may underlie the low systemic toxicity, which differentiates it from other ADCs. Clinical trial information: NCT032550070 .[Table: see text]

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