Nested Variant of Urothelial Carcinoma: A Review and Update of the Literature

2021 ◽  
pp. 113-142
Author(s):  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Urothelial Carcinoma ◽  
Nested Variant

scholarly journals Nested variant of urothelial carcinoma of the urinary bladder

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 132-134 ◽  
Author(s):  
Tadashi Terada
Keyword(s):  
Urothelial Carcinoma ◽  
Lamina Propria ◽  
Bladder Tumor ◽  
Clinical Course ◽  
Carcinoma Cells ◽  
Ki 67 ◽  
Atypical Cells ◽  
Nested Variant ◽  
Aggressive Clinical Course ◽  
Nephrogenic Metaplasia

The nested variant of urothelial carcinoma (NVUC) is characterized by the presence of benign-appearing urothelial carcinoma cells in the lamina propria, sparing the surface urothelial involvement. NVUC shows aggressive clinical course despite of benign-looking histology. Herein reported are two cases of NVUC. One is 80-year-old woman, and another is 78-year-old man. In both cases, atypical cells forming nests and tubules were seen in the lamina propria without surface urothelial involvement. One case resembled nephrogenic metaplasia and another proliferated Brunn's nest or inverted papilloma. Immunohistochemically, both cases showed positive p53 and high Ki67 labeling, suggesting that both cases are malignant. Immunohistochemically, one case was characterized by positive cytokeratins, EMA, p53, Ki-67 (labeling=15%), α-methylacyl CoA racemase, CA19-9, and MUC1, and another case by positive cytokeratins, EMA, p63, p53, Ki-67 (lebeling=30%), CD10, CEA, and MUC1. Cyto keratin immunoprofiles were described and other antigens’ expressions were shown. The patients are now free of tumor 6 and 15 months after the resection of the bladder tumor.

Nested Variant Urothelial Carcinoma of the Bladder

Urology ◽  
2020 ◽  
Vol 144 ◽  
pp. 9-12
Author(s):  
Tracy R. Shachner ◽  
Eric Riedinger ◽  
Alan D. Grindstaff ◽  
James Bienvenu ◽  
Wesley M. White
Keyword(s):  
Urothelial Carcinoma ◽  
Nested Variant ◽  
Carcinoma Of The Bladder

Pure form of a nested variant of urothelial carcinoma of the urinary bladder—A case report—

2015 ◽  
Vol 54 (6) ◽  
pp. 377-382
Author(s):  
Tomonori KOZAKAI ◽  
Keiji IIZUKA ◽  
Kazuyo NISHIZAWA ◽  
Akiko ISHIDA ◽  
Hiroyoshi OTA
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Pure Form ◽  
Nested Variant

Large Nested Variant of Urothelial Carcinoma

2011 ◽  
Vol 35 (9) ◽  
pp. 1337-1342 ◽  
Author(s):  
Roni Cox ◽  
Jonathan I. Epstein
Keyword(s):  
Urothelial Carcinoma ◽  
Nested Variant

MRI features of the nested variant of urothelial carcinoma of the urinary bladder: report of four cases

2020 ◽  
Vol 45 (7) ◽  
pp. 2279-2285
Author(s):  
Kaori Yamada ◽  
Yasuteru Sasakura ◽  
Sachimi Yamada ◽  
Hitomi Nagano ◽  
Koshi Terayama ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Mri Features ◽  
Nested Variant

Genomic determinants of nested variant urothelial carcinoma.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 538-538
Author(s):  
Timothy Nguyen Clinton ◽  
Karissa Whiting ◽  
Vitor Silva ◽  
Qiang Li ◽  
Nima Almassi ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
High Grade ◽  
Cancer Genes ◽  
Sequencing Data ◽  
Genomic Alterations ◽  
Specific Mortality ◽  
Tumor Mutational Burden ◽  
Nested Variant ◽  
Cancer Specific Mortality ◽  
Risk Of Cancer

538 Background: Nested variant urothelial carcinoma (NVUC) is a historically aggressive variant of bladder cancer with management reliant on radical cystectomy given unclear effectiveness of chemotherapy. Given the aggressive behavior of NVUC, the identification of pathogenic and potentially targetable genomic alterations could suggest novel treatment paradigms for this rare histologic variant. Methods: Query of our institutional database identified 81 cases of clinically localized NVUC. Each case was re-reviewed by GU pathologists to confirm the histology. Targeted capture sequencing was performed to define the spectrum of genomic alterations in known and putative cancer genes. Clinical and sequencing data was then compared between the nested variant cases and a prospective cohort of clinically localized high-grade urothelial carcinomas, not otherwise specified (UC NOS). Results: On central re-review, tumors were classified as either classic NVUC (N=53) or high-grade urothelial carcinoma with nested features (N=28). A cohort of UC NOS patients (N=600) was used as a comparator. Median follow-up of the overall cohort was 4.3 years. Classic NVUC was associated with higher risk of cancer specific mortality compared to UC NOS on multivariate analysis (HR 1.76, p=0.04). Tumor mutational burden was lower in classic NVUC tumors versus UC NOS. Evaluation of 136 cancer-associated genes identified differences in mutational frequencies across the 3 cohorts (Table) with RhoA and FOXA1 alterations enriched in NVUC. Conclusions: Patients with NVUC have significantly higher risk of cancer specific mortality than patients with UC NOS. While there was significant overlap between the landscape of genomic alterations in NVUC and UC NOS tumors, NVUC tumors were enriched for RhoA and FOXA1 alterations among others.[Table: see text]

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