Acute and Sub-acute Oral Toxicity Study of Drepanoalpha® (A Poly-Herbal Formula Used in the Management of Sickle Cell Disease) in Guinea-pigs

2016 ◽  
Vol 10 (5) ◽  
pp. 1-8 ◽  
Author(s):  
P Mpiana ◽  
F Kasali ◽  
F Bwirhonde ◽  
B Gbolo ◽  
D Tshibangu ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Guinea Pigs ◽  
Toxicity Study ◽  
Herbal Formula ◽  
Acute Oral Toxicity ◽  
Cell Disease ◽  
Oral Toxicity

scholarly journals Preliminary report of a toxicity study of hydroxyurea in sickle cell disease

1999 ◽  
Vol 81 (5) ◽  
pp. 437-439 ◽  
Author(s):  
M de Montalembert ◽  
P Begue ◽  
F Bernaudin ◽  
I Thuret ◽  
D Bachir ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Preliminary Report ◽  
Toxicity Study ◽  
Cell Disease

scholarly journals Acute and Subacute Oral Toxicity Studies and Anti-Sickling Activity Assessment of FACA® Syrup

2020 ◽  
Vol 10 (5-s) ◽  
pp. 40-50
Author(s):  
Geoffroy Gueswindé OUEDRAOGO ◽  
Sylvain ILBOUDO ◽  
Salfo OUEDRAOGO ◽  
Jean Claude Romaric Pingdwendé OUEDRAOGO ◽  
Gaëtan Donzéo SOMDA ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Behavioral Change ◽  
Public Health Problem ◽  
Toxicity Tests ◽  
Major Public Health Problem ◽  
Cell Disease ◽  
Oral Toxicity ◽  
Activity Assessment

Sickle cell disease remains a major public health problem in Burkina Faso and Africa. For the management of this pathology in young children, the Institute for Research in Health Sciences has developed an herbal drug called FACA® syrup. The objective of this study was to verify the safety and pharmacological efficacy of this formulation for its use in the management of sickle cell disease. Acute and subacute oral toxicity tests were performed on Wistar rats in accordance with Organization for Economic Cooperation and Development test guidelines and anti-sickling activity of FACA® syrup was evaluated according to the Emmel test. In the acute test, FACA® syrup didn’t cause mortality or any behavioral change at dose of 2000 mg/kg/b.w suggesting that the test product estimated LD50 is 5000 mg/kg b.w. The results of subacute toxicity study indicate that the daily administration of FACA® syrup during 28 days did not result in significant change on physical, haematological and biochemical parameters up to dose of 1000 mg/kg b.w. The evaluation of effect of FACA® syrup in vitro on sickling revealed that, FACA® syrup possesses a real antisickling activity. Regarding these results FACA® syrup would be considered as safe in both acute and subacute exposure and could be used in the management of sickle cell diseases. Keywords: FACA® syrup, oral toxicity, sickle cell anemia, Antisickling activity

Hemolysis in sickle cell disease

1974 ◽  
Vol 133 (4) ◽  
pp. 624-631 ◽  
Author(s):  
T. A. Bensinger
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease

Computerized cognitive training in pediatric sickle cell disease: A randomized controlled pilot study.

2020 ◽  
Vol 8 (4) ◽  
pp. 390-401 ◽  
Author(s):  
Taryn M. Allen ◽  
Lindsay M. Anderson ◽  
Samuel M. Brotkin ◽  
Jennifer A. Rothman ◽  
Melanie J. Bonner
Keyword(s):  
Pilot Study ◽  
Sickle Cell Disease ◽  
Cognitive Training ◽  
Sickle Cell ◽  
Cell Disease ◽  
Computerized Cognitive Training ◽  
Randomized Controlled ◽  
Pediatric Sickle Cell Disease
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