scholarly journals Anti-Inflammatory and Analgesic Activities of Soft Drink Leaf Extract of Phyllanthus amarus in Some Laboratory Animals

2013 ◽  
Vol 3 (2) ◽  
pp. 191-204 ◽  
Author(s):  
Adeolu Adedapo
Keyword(s):  
Leaf Extract ◽  
Soft Drink ◽  
Laboratory Animals ◽  
Phyllanthus Amarus ◽  
Anti Inflammatory ◽  
Analgesic Activities

Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Adeolu Alex Adedapo ◽  
Olufunke Olubunmi Falayi ◽  
Ademola Adetokunbo Oyagbemi
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Laboratory Animals ◽  
Phytochemical Analysis ◽  
Writhing Test ◽  
Analgesic Effects ◽  
Anti Oxidant ◽  
Anti Inflammatory

AbstractThe commercially processedThe phytochemical analysis showed that the extract contained flavonoids, terpenoids, glycosides, tannins and saponins. In the acetic acid-induced writhing test, the extract significantly reduced the number of writhes at 100 and 200 mg/kg but not so much at 50 mg/kg. In the formalin-induced paw lick test, the effect was similar to that of the acetic writhing test. The analgesic effects were comparable to that of indomethacin used at 10 mg/kg. In the anti-inflammatory test, the extract reduced the formation of oedema especially at a dose of 200 mg/kg. In the anti-oxidant test, the extract was found to possess a free radical-scavenging property and is concentration related.The use of this extract for medicinal and nutritional purposes may have thus been justified; however, caution must be exercised in its use to prevent the toxic effect.

Anti-inflammatory and antinociceptive activities of the aqueous leaf extract of Phyllanthus amarus Schum (Euphorbiaceae) in some laboratory animals

2015 ◽  
Vol 26 (1) ◽  
Author(s):  
Adeolu A. Adedapo ◽  
Sunday O. Ofuegbe
Keyword(s):  
Acetic Acid ◽  
Analgesic Effect ◽  
Leaf Extract ◽  
Herbal Remedy ◽  
Laboratory Animals ◽  
Traditional Use ◽  
Reference Drug ◽  
Anti Inflammatory ◽  
Dose Dependent Decrease ◽  
Dose Dependent

Abstracthas a history of use in Ayurvedic medicine for over 2000 years as well as a wide variety of traditional applications and has gained popularity in many continents as a herbal remedy; hence, it is being assessed for its safety potential and anti-inflammatory and analgesic properties in some laboratory animals.Standard phytochemical methods were used to test for the presence of phytoactive compounds in the plant. Acute toxicity testing was carried out in mice to determine safe doses for the extract. The anti-inflammatory activity of the leaf extract of this plant was assessed using carrageenan-induced and histamine-induced paw edema. The analgesic effect was determined using the acetic acid writhing method as well as formalin test.The extract at 100 and 200 mg/kg body weight reduced significantly, the formation of edema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by reduction in the number of writhes when compared to the control. The extract caused dose-dependent decrease of licking time in rats injected with 2.5% formalin, signifying its analgesic effect. These results were also comparable to those of ibuprofen, the reference drug used in this study.The plant extract reduced significantly the formation of edema induced by carrageenan and histamine as well as reducing the number of writhes in acetic acid-induced writhing models and dose-dependent decrease of licking time in rats injected with 2.5% formalin. The results have validated the basis for the traditional use of

Anti-Inflammatory and Analgesic Activities of Chaenomeles speciosa Fractions in Laboratory Animals

2009 ◽  
Vol 12 (5) ◽  
pp. 1016-1022 ◽  
Author(s):  
X. Li ◽  
Y.-B. Yang ◽  
Q. Yang ◽  
L.-N. Sun ◽  
W.-S. Chen
Keyword(s):  
Laboratory Animals ◽  
Anti Inflammatory ◽  
Analgesic Activities
Sign in / Sign up

Export Citation Format

Share Document