scholarly journals DESIGN AND IN VITRO EVALUATION STUDIES OF DICLOFENAC SODIUM FLOATING MATRIX TABLETS BY MELT GRANULATION TECHNIQUE

2013 ◽  
Vol 4 (5) ◽  
pp. 150-154
Author(s):  
Subramaniyan Chandra ◽  
S Gopi ◽  
Biyogo ogetii alex ◽  
Omarbakri nasreidin elsayed ◽  
Oleti Chandra sai pavan
Keyword(s):  
Evaluation Studies ◽  
Diclofenac Sodium ◽  
Matrix Tablets ◽  
In Vitro Evaluation ◽  
Melt Granulation

In-vitro evaluation studies of 7-chloro-4-aminoquinoline Schiff bases and their copper complexes as cholinesterase inhibitors

2019 ◽  
Vol 191 ◽  
pp. 183-193 ◽  
Author(s):  
Vanessa S. Zanon ◽  
Josélia A. Lima ◽  
Teobaldo Cuya ◽  
Flavia R.S. Lima ◽  
Anna C.C. da Fonseca ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Copper Complexes ◽  
Cholinesterase Inhibitors ◽  
Evaluation Studies ◽  
In Vitro Evaluation

FORMULATION AND IN-VITRO EVALUATION OF ZOLMITRIPTAN IN SITU GEL FOR NASAL ADMINISTRATION

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (12) ◽  
pp. 54-58
Author(s):  
P. H Patil ◽  
◽  
V. S Belgamwar ◽  
D. A Patel ◽  
S. J. Surana
Keyword(s):  
Evaluation Studies ◽  
Methyl Cellulose ◽  
Nasal Delivery ◽  
Nasal Administration ◽  
Histopathological Study ◽  
In Situ Gel ◽  
In Vitro Evaluation ◽  
Effective Delivery

The aim of present investigation was formulation and in-vitro evaluation of in situ gel for the nasal delivery of zolmitriptan. The in situ gel was prepared by temperature induced gelation technique using Pluronic with mucoadhesive polymer hydroxy propyl methyl cellulose K4 M in different ratios. The in situ gels so prepared were characterized and from the evaluation studies, batch PH2 was optimized and further subjected for stability studies at 30±2°C and 60±5% RH for 90 days. These formulations retained good stability at accelerated conditions and also did not show any remarkable damage to nasal mucosa in histopathological study. Owing to these properties it can be used as an effective delivery system for the nasal route.

DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE MATRIX TABLETS OF MILNACIPRAN HCL USING MELT GRANULATION TECHNIQUE

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (02) ◽  
pp. 68-71
Author(s):  
N. C Ratnakara ◽  
◽  
M. C. Gohel
Keyword(s):  
Drug Release ◽  
Matrix Tablets ◽  
Matrix Tablet ◽  
Modified Release ◽  
Independent Variables ◽  
Dependent Variables ◽  
Formulation Parameters ◽  
Predicted Values ◽  
Melt Granulation

The objective of the present study was to identify critical formulation parameters affecting the drug release from modified release wax matrix tablet of milnacipran hydrochloride employing the concept of design of experiments.The optimized amount of Compritol 888 ATO(intragranular) (X1), lactose (X2) and Compritol 888ATO (extragranular)(X3) were determined employing simplex latticedesign. The tablets were prepared using melt granulation technique. The in vitro drug release study was carried out in an acidic medium (pH 1.2) for 2 h and thereafter the dissolution study was conducted in phosphate buffer (pH 6.8).The selected dependent variables were the cumulative percentage of milnacipran hydrochloride dissolved at 1 (Y1), 8 (Y8), 16 (Y16) and 24 h (Y24). Mathematical models, correlating the independent variables with dependent variables were evolved. Optimization was performed for the three independent variables using the stated target ranges; Y1≤20%; Y8=45±5%; Y16=72±5%; Y24=100%. The optimized amounts of Compritol ATO888 (intragranular)(X1), lactose (X2) and Compritol 888ATO (extragranular)(X3), were found to be 60, 55 and 30 mg, respectively.The optimized formulation showed a release profile that was close to the predicted values. The drug was released by anomalous diffusion from the optimized formulation. Compritol 888ATO (intragranular) (X1), lactose (X2) and Compritol 888ATO(extragranular) (X3) were identified as critical variables.

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