scholarly journals Clinical Significance of Serum Ribonuclease (RNase) Assay in Acute Leukemia

1987 ◽  
Vol 9 (1) ◽  
pp. 35-43
Author(s):  
Keiichi MARUOKA ◽  
Masayoshi YAMANAKA ◽  
Susumu ODA ◽  
Shozo CHIBA ◽  
Sumiya ETO
Keyword(s):  
Acute Leukemia ◽  
Clinical Significance ◽  
Serum Ribonuclease

Clinical significance of HLA-E genotype and surface/soluble expression levels between healthy individuals and patients with acute leukemia

2018 ◽  
Vol 60 (1) ◽  
pp. 208-215 ◽  
Author(s):  
Yun-Ping Xu ◽  
Lotte Wieten ◽  
Song-Xing Wang ◽  
Yun Cai ◽  
Timo Olieslagers ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Significance ◽  
Soluble Expression ◽  
Healthy Individuals ◽  
Expression Levels

scholarly journals Peripheral blood blast cell progenitors in human preleukemia

Blood ◽  
1982 ◽  
Vol 59 (1) ◽  
pp. 106-109 ◽  
Author(s):  
JS Senn ◽  
HA Messner ◽  
PH Pinkerton ◽  
L Chang ◽  
B Nitsch ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Significance ◽  
Peripheral Blood ◽  
Tritiated Thymidine ◽  
Blast Cell ◽  
Short Term ◽  
Short Term Exposure

Abstract Progenitors of blast cell colonies have been identified in acute leukemia. The peripheral blood of 18 of 25 patients with preleukemic states yielded low numbers of blast cell colonies, and the colony- forming cells were in an active proliferative state when assessed using short-term exposure to tritiated thymidine. The clinical significance of blast cell colonies is uncertain, but we suggest that further analysis of this cultural abnormality may lead to a better understanding of mechanisms and management in preleukemia.

The Expression and Clinical Significance of PRAME Gene in Acute Leukemia.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4225-4225
Author(s):  
Rong Fu ◽  
Kai Ding ◽  
Zonghong Shao
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Clinical Significance ◽  
Blood Count ◽  
Mononuclear Cells ◽  
Residual Disease ◽  
White Blood Count ◽  
Gene Expressions ◽  
Healthy Donors ◽  
Blast Cells

Abstract Objective To investigate the expression of PRAME (preferentially expressed antigen of melanoma) gene in acute leukemia and its clinical significance in monitoring prognosis, detecting minimal residual disease (MRD) and gene immunotherapy. Methods The expression of PRAME gene mRNA in bone marrow mononuclear cells is measured by reverse transcriptase polymerase chain reaction in 34 patients with acute leukemia and 12 bone marrow samples of health donors. The relationships between PRAME gene expressions and some clinical data, such as gender, age, white blood count, leukemic immunophenotype, the percentage of blast cells, and the karyotype of chromosome, were also estimated. Results PRAME gene was expressed in 38.2% of all the patients, 40.7% of all the AML patients, which was higher than the 28.6% of ALL patients (p >0.05). There was no expression of PRAME gene in healthy donors. In all the sub phenotypes of AML, the expressive rate of PRAME gene in M3 patients is 80%, which is higher than that in M2 (33.3%) and in M5 (28.6%). The expressive rate of PRAME gene was also positively correlated with the expression of CD15, CD33, and the abnormality in the karyotype of chromosome, but not correlated with age, gender, white blood count and percentage of blast cell in bone marrow. Conclusion PRAME gene is highly expressed in acute leukemia, and could be regarded as a useful tool for monitoring MRD. Differential expression in acute leukemia patients vs. healthy donors suggests that the immunogenic antigens PRAME are potential candidates for immunotherapy in acute leukemia.

Clinical significance of the TNF-α receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia

Cytokine ◽  
2018 ◽  
Vol 111 ◽  
pp. 523-529 ◽  
Author(s):  
Nabila El Kramani ◽  
Nehal M. Elsherbiny ◽  
Amal M. El-Gayar ◽  
Mohamed A. Ebrahim ◽  
Mohammed M.H. Al-Gayyar
Keyword(s):  
Cell Migration ◽  
Acute Leukemia ◽  
Clinical Significance ◽  
Tnf Α

The clinical significance of multidrug resistance gene (mdr1) expression in acute leukemia

1998 ◽  
Vol 10 (1) ◽  
pp. 59-62
Author(s):  
Zuoren Dong ◽  
Jianmin Luo ◽  
Wenxin Xu ◽  
Fuxu Wang ◽  
Xiaonan Guo ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Acute Leukemia ◽  
Resistance Gene ◽  
Clinical Significance ◽  
Multidrug Resistance Gene ◽  
Mdr1 Expression
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