scholarly journals A Randomized Controlled Trial : A Study designed to collect the Best Evidence demonstrating that Surgical Management is better than Medical Management

2000 ◽  
Vol 9 (6) ◽  
pp. 409-415 ◽  
Author(s):  
Etsuro Mori
Keyword(s):  
Randomized Controlled Trial ◽  
Surgical Management ◽  
Medical Management ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Better Than

scholarly journals High-Intensity Interval Circuit Training Versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness in Middle-Aged and Older Women: A Randomized Controlled Trial

2020 ◽  
Vol 17 (5) ◽  
pp. 1805 ◽  
Author(s):  
Ismael Ballesta-García ◽  
Ignacio Martínez-González-Moro ◽  
Domingo J Ramos-Campo ◽  
María Carrasco-Poyatos
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trial ◽  
Older Women ◽  
Controlled Trial ◽  
Moderate Intensity ◽  
Middle Aged ◽  
Continuous Training ◽  
Randomized Controlled ◽  
High Intensity Interval ◽  
Better Than

High-intensity interval training (HIIT) has similar or better effects than moderate-intensity continuous training (MICT) in increasing peak oxygen consumption (VO2max), however, it has not been studied when HIIT is applied in a circuit (HIICT). The aim of this study was to compare the effects of a HIICT versus MICT on VO2max estimated (VO2max-ES), heart rate (HR) and blood pressure (BP) of middle-aged and older women. A quasi-experimental randomized controlled trial was used. Fifty-four women (67.8 ± 6.2 years) were randomized to either HIICT (n = 18), MICT (n = 18) or non-exercise control group (CG; n = 18) for 18 weeks. Participants in HIICT and MICT trained two days/week (one hour/session). Forty-one participants were assessed (HIICT; n = 17, MICT; n = 12, CG; n = 12). Five adverse events were reported. Cardiorespiratory fitness, HR and BP were measured. The tests were performed before and after the exercise intervention programs. VO2max-ES showed significant training x group interaction, in which HIICT and MICT were statistically superior to CG. Moreover, HIICT and MICT were statistically better than CG in the diastolic blood pressure after exercise (DBPex) interaction. For the systolic blood pressure after exercise (SBPex), HIICT was statistically better than CG. In conclusion, both HIICT and MICT generated adaptations in VO2max-ES and DBPex. Furthermore, only HIICT generated positive effects on the SBPex. Therefore, both training methods can be considered for use in exercise programs involving middle-aged and older women.

Combined oral midazolam-ketamine better than midazolam alone for sedation of young children: a randomized controlled trial

2012 ◽  
Vol 23 (3) ◽  
pp. 207-215 ◽  
Author(s):  
THIAGO ANDERSON MOREIRA ◽  
PAULO SUCASAS COSTA ◽  
LUCIANE REZENDE COSTA ◽  
CRISTIANA MARINHO JESUS-FRANÇA ◽  
DENISE ESPÍNDOLA ANTUNES ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Young Children ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Oral Midazolam ◽  
Better Than

scholarly journals Efficacy of Clarithromycin Versus Methylprednisolone in the Treatment of Non-Eosinophilic and Eosinophilic Nasal Polyposis: A Randomized Controlled Trial

2018 ◽  
Vol 33 (2) ◽  
pp. 6-13
Author(s):  
Jemilyn C. Gammad ◽  
Antonio H. Chua ◽  
Charmaine S. Templonuevo-Flores
Keyword(s):  
Randomized Controlled Trial ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Controlled Trial ◽  
Well Being ◽  
Randomized Controlled ◽  
Eosinophil Cell ◽  
Significant Difference ◽  
Snot 22 ◽  
Better Than

Objective: To compare the efficacy of Clarithromycin versus Methylprednisolone in the treatment of non-eosinophilic and eosinophilic nasal polyposis. Methods:             Study Design: Randomized controlled trial             Setting:           Tertiary Government Training Hospital Subjects:         Forty two patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) were grouped into non-eosinophilic and eosinophilic groups after biopsy determination of eosinophil count. Both groups were further randomized into a treatment arm given Clarithromycin (CLA) 500 mg/ day and another arm given Methylprednisolone (METH) 32 mg/ day tapering to 8 mg/ day for 15 days. All participants underwent pre– and post–treatment evaluation via anterior rhinoscopy, Sino-Nasal Outcome Test (SNOT-22) and Endoscopic Appearance (EA) Scoring. Data were encoded and subjected to statistical analysis using Mann-Whitney U test. Results: For the 9 participants in the non-eosinophilic group, 4 were given CLA and 5 were given METH. The CLA arm showed significant improvement in SNOT-22 scores by the 15th day (p= .007). The METH arm did not demonstrate significant improvement by the 7th (p= .44) or 15th day (p= .22). Comparison of the improvement in SNOT-22 scores between the two arms showed that on both 7th and 15th days, CLA outperformed METH (p= .026 and p= .004, respectively). For the EA scoring, both the CLA and METH groups significantly improved by the 7th (p= .027 and p= 0.017, respectively), and 15th day (p= .013 and p= .027, respectively). Comparison of the improvement in EA scores between the two arms showed significant difference on the 15th day (p= .01), with the CLA performing better than METH. Overall, the results suggest that the CLA arm performed significantly better than the METH arm in the treatment of non-eosinophilic patients.           Of the 33 eosinophilic patients, 17 were given CLA and 16 were given METH. The CLA arm showed significant improvement in SNOT-22 scores by the 15th day (p < .001), while the METH arm on both 7th (p= .033) and 15th day (p< .001). Comparison of the improvement in SNOT-22 results between the two arms showed no significant differences (7th day p= .494; 15th day p= .587). For the EA scoring, both treatment groups showed significant improvement by the 7th and 15th day (p< .001). Comparison of the improvement in EA scores between the two arms showed significant differences (p< .001) on both 7th and 15th day, suggesting that METH was more effective than CLA. Overall, the results showed that both CLA and METH were effective in the treatment of eosinophilic nasal polyps. However, METH was significantly better than CLA in terms of superior EA scores. Conclusion: In terms of improving symptoms and well-being, as well as decreasing nasal polyp size and reducing discharge and edema as reflected in superior SNOT-22 and EA scores, Clarithromycin was significantly more effective than Methylprednisolone in the treatment of non-eosinophilic nasal polyps. While both Clarithromycin and Methylprednisolone were shown to be effective in the treatment of eosinophilic nasal polyps, Methylprednisolone was significantly better than Clarithromycin in terms of superior EA scores. A biopsy for tissue eosinophil cell count prior to treatment is recommended to establish the predominant inflammatory cell in nasal polyps in order to provide appropriate targeted treatment, i.e. Clarithromycin for non-eosinophilic nasal polyps and Methylprednisolone for eosinophilic polyps. Keywords: macrolides, clarithromycin, methylprednisolone, nasal polyps, eosinophils

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