scholarly journals Residual Gadolinium from MRI Contrast Agents in the Brain : A Health Risk Assessment

2017 ◽  
Vol 26 (11) ◽  
pp. 776-781
Author(s):  
Tomonori Kanda
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Contrast Agents ◽  
Health Risk Assessment ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
The Brain

Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents

2021 ◽  
Vol 118 (42) ◽  
pp. e2102340118
Author(s):  
He Wei ◽  
Agata Wiśniowska ◽  
Jingxuan Fan ◽  
Peter Harvey ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Brain Parenchyma ◽  
Mri Contrast Agents ◽  
Imaging Agents ◽  
Mri Contrast ◽  
Blood Brain Barrier Disruption ◽  
Brain Barrier Disruption ◽  
The Brain ◽  
Superparamagnetic Properties

Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T1-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood–brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials.

scholarly journals Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound

Theranostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 2659-2674 ◽  
Author(s):  
Sophie V. Morse ◽  
Tamara Boltersdorf ◽  
Bethany I. Harriss ◽  
Tiffany G. Chan ◽  
Nicoleta Baxan ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Focused Ultrasound ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
The Brain

Heavy metals exposure and health risk assessment of PM10 particles in indoor air in industrial area

2019 ◽  
Vol 18 (1) ◽  
pp. 18-27
Author(s):  
Yujin Oh ◽  
YoonDeok Han ◽  
Yunjae Kim ◽  
Sunghyeon Jung ◽  
Wonhee Jung ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Indoor Air ◽  
Industrial Area ◽  
Metals Exposure

Human health risk assessment: application of the NORISC-HRA and ROME models at two test sites

2006 ◽  
Vol 14 (2) ◽  
pp. 559-570 ◽  
Author(s):  
F. Quercia ◽  
A. Vecchio ◽  
M. Falconi ◽  
L. Togni ◽  
E. Wcislo ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Human Health Risk ◽  
Human Health Risk Assessment
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