scholarly journals Clinical Manifestations of Coxsackievirus A6 Infection Associated with a Major Outbreak of Hand, Foot, and Mouth Disease in Japan

2013 ◽  
Vol 66 (3) ◽  
pp. 260-261 ◽  
Author(s):  
Masaaki Kobayashi ◽  
Tomohiko Makino ◽  
Nozomu Hanaoka ◽  
Hiroyuki Shimizu ◽  
Miki Enomoto ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth ◽  
Major Outbreak

scholarly journals Characterization of oral virome and microbiome revealed distinctive microbiome disruptions in paediatric patients with hand, foot and mouth disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Si Xian Ho ◽  
Nyo Min ◽  
Emmerie Phaik Yen Wong ◽  
Chia Yin Chong ◽  
Justin Jang Hann Chu
Keyword(s):  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Human Microbiome ◽  
Foot And Mouth Disease ◽  
Critical Factor ◽  
Mouth Disease ◽  
Oral Microbiome ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

AbstractWhile the underlying determinants are unclear, hand, foot and mouth disease (HFMD) presents a wide spectrum of clinical manifestations with varying severity in different individuals. Recently, many studies identified the human microbiome as a critical factor in the pathogenesis of various diseases. Therefore, we here investigated the ecological dynamics of the oral microbiome changes during the HFMD infection. After targeted enrichment of all known vertebrate viruses, the virome profiles of symptomatic and asymptomatic HFMD patients were examined and revealed to be significantly altered from those of healthy individuals, with nine discriminative viruses detected. Further characterization of the prokaryotic microbiome revealed an elevated level of Streptococcus sp. as the most important signature of the symptomatic HFMD cohort, positively correlating to the level of enterovirus A RNA. In addition, we found that while coxsackievirus A5 is detected in saliva RNA of all asymptomatic cases, coxsackievirus A6 dominates the majority of the symptomatic cohort.

scholarly journals Neonatal hand, foot, and mouth disease due to Coxsackievirus A6 in Shanghai

2020 ◽  
Author(s):  
Shanshan Xu ◽  
Huajun Li ◽  
Peng Qiao ◽  
Guofeng Xu ◽  
Dongying Zhao ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
White Blood Cells ◽  
Clinical Manifestations ◽  
Foot And Mouth Disease ◽  
Nonparametric Test ◽  
Peripheral Blood Lymphocytes ◽  
Mouth Disease ◽  
Logistic Analysis ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

Abstract Background: Evidence of hand, foot, and mouth disease (HFMD) in neonates is limited. The aim of this study was to evaluate the clinical symptoms, pathogens, possible transmission routes, and prognosis of neonatal HFMD in Shanghai. Methods: This was a case-control study based on the HFMD registry surveillance system. All neonates and infected family members were enrolled between 2016 and 2017 in Shanghai. Neonates with HFMD were followed for at least half a year. Detailed questionnaires, medical history, and physical examination were recorded. Routine blood examination, liver and renal function, immunophenotypes of peripheral blood lymphocytes (CD3, CD4, and CD8 T-cells; NK cells), immunoglobulin (Ig) M, IgG, and IgA, and cytokine interleukin (IL-1β, IL-2R, IL-6, IL-8, IL-10, and TNF-α) levels were measured. All rectal swab specimens were collected and genotyped for enterovirus, and phylogenetic analysis based on the VP1 sequences of coxsackievirus A6 (CV-A6) was performed to investigate molecular and evolutionary characteristics. T-test or nonparametric test was used to evaluate the differences. Logistic analysis was applied to calculate the risk of clinical manifestations in the group of HFMD neonates and their paired siblings. Results: There were 16 neonates among the 12608 diagnosed patients with HFMD, accounting for 0.13%. All neonatal infections were transmitted by other members of the family, mainly the elder siblings, and were caused by CV-A6. CV-A6 was the emerging and predominant causative agent of HFMD in Shanghai. None of the neonates with HFMD experienced fever, onychomadesis, or severe complications. However, two elder sibling patients showed lethargy, and one developed hypoperfusion. In the elder siblings with HFMD, the proportion of white blood cells was generally higher than in neonates with HFMD. The immunologic function of the neonates with HFMD was basically normal. The levels of inflammatory markers were higher in both neonates and elder siblings with HFMD compared to age-matched controls. The clinical symptoms receded about one week after onset. None of the neonates had sequelae. Conclusions: In our study, CV-A6 infection in neonates was benign, but had the character of family clustering. Due to the two-child policy in China, elder siblings may be the main route of HFMD transmission.

scholarly journals An outbreak of Coxsackievirus A6–associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jie Li ◽  
Rong Zhu ◽  
Da Huo ◽  
Yiwei Du ◽  
Yuxiang Yan ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

Prevalence of Coxsackievirus A6 and Enterovirus 71 in Hand, Foot and Mouth Disease in Nanjing, China in 2013

2015 ◽  
Vol 34 (9) ◽  
pp. 951-957 ◽  
Author(s):  
Ya-Qian Hu ◽  
Guang-Cheng Xie ◽  
Dan-Di Li ◽  
Li-Li Pang ◽  
Jing Xie ◽  
...  
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

scholarly journals Description of the pathology of a gazelle that died during a major outbreak of foot-and-mouth disease in Israel : clinical communication

2010 ◽  
Vol 81 (1) ◽  
Author(s):  
A. Berkowitz ◽  
T. Waner ◽  
R. King ◽  
H. Yadin ◽  
S. Perl
Keyword(s):  
Pancreatic Necrosis ◽  
Nature Reserve ◽  
Incidental Finding ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Clinical Communication ◽  
Naturally Occurring ◽  
Foot And Mouth ◽  
Major Outbreak ◽  
Cardiac Necrosis

Naturally occurring foot-and-mouth disease (FMD) in wildlife is a relatively mild condition but occasionally it can be devastating as has been documented in impala in South Africa and in mountain gazelles in Israel. This report describes pathological changes in an adult male gazelle with FMD from an outbreak in the Nature Reserve of Ramot-Issachar region and the lower Galilee in Israel. The outbreak was characterised by the malignant form of the disease, which is uncommon among domestic animals. Lesions observed included, ulceration in the oral cavity, oesophagus and ruminal pillars, coronitis, multifocal cardiac necrosis and pancreatic necrosis and inflammation. Pneumonia, caused by Muellerius capillaries was an incidental finding.

scholarly journals An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since 2013

Virology ◽  
2018 ◽  
Vol 518 ◽  
pp. 328-334 ◽  
Author(s):  
Shuizhen He ◽  
Mengyuan Chen ◽  
Wenhui Wu ◽  
Qiang Yan ◽  
Zhihao Zhuo ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

An outbreak of hand-foot-and-mouth disease mimicking chicken pox, with a frequent association of onychomadesis in Japan in 2009: A new phenotype caused by coxsackievirus A6

2014 ◽  
Vol 24 (1) ◽  
pp. 103-104 ◽  
Author(s):  
Asako Miyamoto ◽  
Rumiko Hirata ◽  
Kazuhisa Ishimoto ◽  
Mayumi Hisatomi ◽  
Rieko Wasada ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Chicken Pox ◽  
Coxsackievirus A6 ◽  
Foot And Mouth

Clinical features and phylogenetic analysis of severe hand-foot-and-mouth disease caused by Coxsackievirus A6

2020 ◽  
Vol 77 ◽  
pp. 104054 ◽  
Author(s):  
Xiaohan Yang ◽  
Yuanyuan Li ◽  
Changbin Zhang ◽  
Wenli Zhan ◽  
Jia Xie ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Clinical Features ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackievirus A6 ◽  
Foot And Mouth
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