scholarly journals Development of determination method for nitrogen dioxide in indoor air using high performance liquid chromatography

2018 ◽  
Vol 21 (3) ◽  
pp. 181-188
Author(s):  
Kousuke BABA ◽  
Ai NAKAMURA ◽  
Toshiro MATSUMURA ◽  
Yukitoki MORITA ◽  
Kunitoshi MATSUNOBU ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Nitrogen Dioxide ◽  
Indoor Air ◽  
High Performance ◽  
Determination Method

Serotonin Content of the Lungs, Brains, and Blood of Mice Exposed to 0.45 ppm Nitrogen Dioxide

1986 ◽  
Vol 5 (6) ◽  
pp. 583-588 ◽  
Author(s):  
R. P. Sherwin ◽  
J. C. Shih ◽  
J. D. Lee ◽  
R. Ransom
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Air Quality ◽  
Young Adult ◽  
Nitrogen Dioxide ◽  
Air Pollutants ◽  
High Performance ◽  
Control Group ◽  
Serotonin Content ◽  
Hydroxyindoleacetic Acid

Young adult male Swiss Webster mice were exposed to 0.45 ppm of nitrogen dioxide (NO2) for 7 hours per day for 4 weeks. The lungs and brains were assayed for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content by high-performance liquid chromatography. Lung 5-HT content for the exposed animals was 13.1% less than that for the control group, but this difference was not statistically significant. Brain 5-HT and 5-HIAA were significantly elevated, +17.3% (P < 0.005) and +47.3% (P 0.001), respectively, and the ratios of 5-HIAA to 5-HT were also higher (P 0.005). The results suggest that further exploration of lung and brain serotonin alterations by air pollutants may offer useful discriminates for the evaluation of air quality.

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