scholarly journals Immunoproliferative small intestinal disease: a report of 6 cases

2014 ◽  
Vol 35 (4) ◽  
pp. 269-272
Author(s):  
Bivas Biswas
Keyword(s):  
Intestinal Disease ◽  
Immunoproliferative Small Intestinal Disease ◽  
Small Intestinal ◽  
Small Intestinal Disease

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms

Blood ◽  
2005 ◽  
Vol 105 (6) ◽  
pp. 2274-2280 ◽  
Author(s):  
Tahseen Al-Saleem ◽  
Hamid Al-Mondhiry
Keyword(s):  
B Cell ◽  
Plasma Cell ◽  
Heavy Chain ◽  
Early Stage ◽  
B Cell Lymphoma ◽  
Intestinal Disease ◽  
Molecular Features ◽  
Immunoproliferative Small Intestinal Disease ◽  
Small Intestinal ◽  
Small Intestinal Disease

AbstractImmunoproliferative small intestinal disease (IPSID) was recently added to the growing list of infectious pathogen-associated human lymphomas. Molecular and immunohistochemical studies demonstrated an association with Campylobacter jejuni. IPSID is a variant of the B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), which involves mainly the proximal small intestine resulting in malabsorption, diarrhea, and abdominal pain. Geographically, IPSID is most prevalent in the Middle East and Africa. IPSID lymphomas reveal excessive plasma cell differentiation and produce truncated α heavy chain proteins lacking the light chains as well as the first constant domain. The corresponding mRNA lacks the variable heavy chain (VH) and the constant heavy chain 1 (CH1) sequences and contains deletions as well as insertions of unknown origin. The encoding gene sequence reveals a deletion of V region and parts of CH1 domain. Cytogenetic studies demonstrated clonal rearrangements involving predominantly the heavy and light chain genes, including t(9;14) translocation involving the PAX5 gene. Early-stage IPSID responds to antibiotics (30%-70% complete remission). Most untreated IPSID patients progress to lymphoplasmacytic and immunoblastic lymphoma invading the intestinal wall and mesenteric lymph nodes, and may metastasize to a distant organ. IPSID lymphoma shares clinical, morphologic, and molecular features with MALT lymphoma, lymphoplasmacytic lymphoma, and plasma cell neoplasms.

Lymphomes malins non hodgkiniens de l’intestin grêle de type « immunoproliferative small intestinal disease »

2011 ◽  
Vol 40 (11) ◽  
pp. 995-1000 ◽  
Author(s):  
Hind Mrabti ◽  
Ghizlane Raiss ◽  
Soundouss Raissouni ◽  
El Mehdi Tazi ◽  
Hanane Inghaouen ◽  
...  
Keyword(s):  
Intestinal Disease ◽  
Immunoproliferative Small Intestinal Disease ◽  
Small Intestinal ◽  
Small Intestinal Disease

scholarly journals HLA AW19, B12 in immunoproliferative small intestinal disease.

Gut ◽  
1979 ◽  
Vol 20 (3) ◽  
pp. 226-228 ◽  
Author(s):  
B Nikbin ◽  
M Banisadre ◽  
F Ala ◽  
A Mojtabai
Keyword(s):  
Intestinal Disease ◽  
Immunoproliferative Small Intestinal Disease ◽  
Small Intestinal ◽  
Small Intestinal Disease
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